Multiple intravenous tranexamic acid doses in total knee arthroplasty without tourniquet: a randomized controlled study

Tzatzairis, Themistoklis; Drosos, Georgios I.; Vogiatzaki, Theodosia; Tilkeridis, Konstantinos; Ververidis, Athanasios; Kazakos, Konstantinos

doi:10.1007/s00402-019-03173-z

Cited by 37 publications

(37 citation statements)

References 42 publications

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“…Compared with the topical regimen, the IV regimen effectively reduced blood loss by approximately 28 mL (p < 0.001). The topical regimen can effectively reduce TPD by approximately 12 mL, and there was signi cant difference compares with IV regimen; this conclusion was also reached by Artit et al 26 The IV regimen more effectively reduced the real Hb reduction during the perioperative period, similar to the results of Tzatzairis et al 27 Sehat et al 28 rst proposed the concept of HBL and studied the HBL of 63 patients that underwent TKA; they found that HBL accounted for approximately 50% of the TBL. Gao et al 29 found that the TBL of perioperative patients in hip replacement was approximately 859 mL, and the HBL was approximately 525 mL, which accounted for 61% of the TBL.…”

Section: Discussionsupporting

confidence: 72%

Comparison of the Effectiveness and Safety of Intravenous and Topical Regimens of Tranexamic Acid in Complex Tibial Plateau Fracture: A Retrospective Study

Wang

et al. 2020

Preprint

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Background Previous studies have demonstrated the effectiveness and safety of tranexamic acid (TXA) in orthopedics surgery. However, no study has investigated TXA in complex tibial plate surgery. Therefore, the purpose of this study was to confirm the safety and effectiveness of IV (intravenous) TXA and topical TXA.Material and methods This was a retrospective analysis of prospectively collected data. The control group received an equal amount of placebo (physiological saline solution); the IV group received 1.0 g TXA by intravenous injection before the tourniquet was inflated and before the surgical incision was closed, and the topical group received 3.0 g TXA in 75 mL of physiological saline solution before 5 min prior to the final tourniquet release. Perioperative blood loss, vascular events, wound complications, and adverse reactions were compared for the three groups.The pain functional and quality of life (QoL) assessment based on their corresponding scoring system.Results Baseline data were comparable for all groups. The IV group showed the best results for total blood loss (TBL) and hidden blood loss (HBL) (424.5 ± 49.4 ml, 219.3 ± 33.4 ml, respectively, all p values < 0.001). The topical group performed excellently with regard to postoperative vascular events, wound complications, and adverse reactions, but there was no statistical significant in the incidence of these between the groups. In addition, the topical group benefited in reducing postoperative pain.Conclusion This study presents the first information to show that both IV TXA and topical TXA are safe and effective for complex tibial plateau fractures. The IV regimen effectively reduced blood loss during the perioperative period, whereas the topical regimen had a better safety profile and control early postoperative pain.

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Section: Discussionsupporting

confidence: 72%

Comparison of the Effectiveness and Safety of Intravenous and Topical Regimens of Tranexamic Acid in Complex Tibial Plateau Fracture: A Retrospective Study

Wang

et al. 2020

Preprint

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“…this conclusion was also reached by Artit et al 26 The IV regimen more effectively reduced the real Hb reduction during the perioperative period, similar to the results of Tzatzairis et al 27 Sehat et al 28 rst proposed the concept of HBL and studied the HBL of 63 patients that underwent TKA; they found that HBL accounted for approximately 50% of the TBL. Gao et al 29 found that the TBL of perioperative patients in hip replacement was approximately 859 mL, and the HBL was approximately 525 mL, which accounted for 61% of the TBL.…”

Section: Discussionsupporting

confidence: 65%

Comparison of the effectiveness and safety of intravenous and topical regimens of tranexamic acid in complex tibial plateau fracture: a retrospective study

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Previous studies have demonstrated the effectiveness and safety of tranexamic acid (TXA) in orthopedics. However, no study has investigated TXA in complex tibial plate surgery. Therefore, the purpose of this study was to confirm the safety and effectiveness of IV (intravenous) TXA and topical TXA. Material and methods This was a retrospective analysis of prospectively collected data. The control group received an equal amount of placebo (physiological saline solution); the IV group received 1.0 g TXA by intravenous injection before the tourniquet was inflated and before the surgical incision was closed, and the topical group received 3.0 g TXA in 75 mL of physiological saline solution before 5 min prior to the final tourniquet release. Perioperative blood loss, vascular events, wound complications, and adverse reactions were compared for the three groups.The pain functional and quality of life (QoL) assessment based on their corresponding scoring system. Results Baseline data were comparable for all groups. The IV group showed the best results for total blood loss (TBL) and hidden blood loss (HBL) (424.5 ± 29.4 ml, 219.3 ± 33.4 ml, respectively, all p values < 0.001). The topical group performed excellently with regard to postoperative vascular events, wound complications, and adverse reactions, but there was no statistical significant in the incidence of these between the groups.In addition, the topical group benefited in reducing postoperative pain and better QoL. Conclusion This study presents the first information to show that both IV TXA and topical TXA are safe and effective for complex tibial plateau fractures. The IV regimen effectively reduced blood loss during the perioperative period, whereas the topical regimen had a better safety profile and QoL.

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“…Compared with the topical regimen, the IV regimen effectively reduced blood loss by approximately 28 mL (p < 0.001). The topical regimen can effectively reduce TPD by approximately 12 mL, but there was no significant difference to intravenous application; this conclusion was also reached by Artit et al 26 The IV regimen more effectively reduced the real Hb reduction during the perioperative period, similar to the results of Tzatzairis et al 27 Sehat et al 28 first proposed the concept of HBL and studied the HBL of 63 patients that underwent TKA; they found that HBL accounted for approximately 50% of the TBL. Gao et al 29 found that the TBL of perioperative patients in hip replacement was approximately 859 mL, and the HBL was approximately 525 mL, which accounted for 61% of the TBL.…”

Section: Discussionsupporting

confidence: 60%

Comparison of the effectiveness and safety of different regimens of tranexamic acid in complex tibial plateau fracture: a retrospective study

Wang¹,

Yupu²,

Wang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Previous studies have demonstrated the effectiveness and safety of tranexamic acid (TXA) in orthopedics. However, no study has investigated TXA in complex tibial plate surgery. Therefore, the purpose of this study was to confirm the safety and effectiveness of IV (intravenous) TXA and topical TXA. Material and methods This was a retrospective analysis of prospectively collected data. The control group received an equal amount of placebo (physiological saline solution); the IV group received 1.0 g TXA by intravenous injection before the tourniquet was inflated and before the surgical incision was closed, and the topical group received 3.0 g TXA in 75 mL of physiological saline solution before 5 min prior to the final tourniquet release. Perioperative blood loss, vascular events, wound complications, and adverse reactions were compared for the three groups. Results Baseline data were comparable for all groups. The IV group showed the best results for total blood loss (TBL) and hidden blood loss (HBL) (424.5 ± 29.4 ml, 219.3 ± 33.4 ml, respectively, all p values < 0.001). The topical group performed excellently with regard to postoperative vascular events, wound complications, and adverse reactions, but there was no statistical significant in the incidence of these between the groups. Conclusion This study presents the first information to show that both IV TXA and topical TXA are safe and effective for complex tibial plateau fractures. The IV regimen effectively reduced blood loss during the perioperative period, whereas the topical regimen had a better safety profile.

show abstract

Multiple intravenous tranexamic acid doses in total knee arthroplasty without tourniquet: a randomized controlled study

Cited by 37 publications

References 42 publications

Comparison of the Effectiveness and Safety of Intravenous and Topical Regimens of Tranexamic Acid in Complex Tibial Plateau Fracture: A Retrospective Study

Comparison of the Effectiveness and Safety of Intravenous and Topical Regimens of Tranexamic Acid in Complex Tibial Plateau Fracture: A Retrospective Study

Comparison of the effectiveness and safety of intravenous and topical regimens of tranexamic acid in complex tibial plateau fracture: a retrospective study

Comparison of the effectiveness and safety of different regimens of tranexamic acid in complex tibial plateau fracture: a retrospective study

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