The body has mucosa-associated lymphoid tissue (MALT), with the gastrointestinal (Gl) tract having the greatest amount of it. Lymphoma may form when the cell growth in this tissue is aberrant. The small intestine is a common extranodular site of lymphoma, which is a systemic illness. Additionally, it has been proposed that MALT lymphomas (MALTomas) arise as a result of chronic and persistent immunological activation, whether of an autoimmune or infectious type. MALT lymphomas that develop in the duodenum are typically thought to be unrelated to Helicobacter pylori infection. However, some examples show that lymphoma regressed when H. pylori was removed.