Multiple idiopathic cervical root resorption involving all permanent teeth

Xue, Chen; Yu, Xijiao; Yan, Kaixian; Liu, Shuang; Sun, Zhaoze; Li, Shu

doi:10.1111/aej.12398

Cited by 14 publications

(16 citation statements)

References 24 publications

(27 reference statements)

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“…However, significant fluctuations of hormone levels are rarely seen among ECR patients, and only a small number of case reports have described abnormal laboratory examination results. 51 – 53 Thus, the relevance between root resorption and hormone levels calls for further investigation.…”

Section: Pathogenesismentioning

confidence: 99%

External cervical resorption—a review of pathogenesis and potential predisposing factors

Chen¹,

Huang²,

Deng³

2021

Int J Oral Sci

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External cervical resorption (ECR) refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root. Despite being latent in its initial phase, ECR could cause severe damage to mineralized dental tissue and even involve the pulp if not given timely diagnosis and treatment. Nevertheless, the etiology of ECR is still poorly understood, which adds to the difficulty in early diagnosis. ECR has received growing attention in recent years due to the increasing number of clinical cases. Several potential predisposing factors have been recognized in cross-sectional studies as well as case reports. In the meantime, studies on histopathology and pathogenesis have shed light on possible mechanisms of ECR. This review aims to summarize the latest findings in the pathogenesis and potential predisposing factors of ECR, so as to provide pragmatic reference for clinical practice.

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Section: Pathogenesismentioning

confidence: 99%

External cervical resorption—a review of pathogenesis and potential predisposing factors

Chen¹,

Huang²,

Deng³

2021

Int J Oral Sci

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“…After reading the 70 articles selected, 39 were excluded for reasons listed in Figure 1 . The remaining 31 studies were screened for data on medical, clinical, and radiographic factors [ 5 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…In these conditions, periodontal probing could be useful to diagnose the presence of MIR, although this procedure was mentioned in only a few clinical cases. All these observations lead to the fact that radiographic evaluation is essential in MIR detection [ 37 , 38 ]. More recently, the use of CBCT has been frequently reported to manage MIR [ 22 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Decision making between a conservative approach or extraction is even more complicated by the fact that further resorption was sometimes found after an initial conservative treatment. A possible explanation could be that small resorptions might go undetected during the radiographic evaluation and evolve after treatment [ 38 ]. However, it was found that resorption continued even in the MTA-treated teeth [ 9 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

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The Medical, Clinical, and Radiographic Aspects of Multiple Idiopathic Tooth Resorption: A Systematic Review

Richert

Santamaria

Laforest

et al. 2022

JPM

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Background: Many causes of resorption remain unclear and are thus identified as idiopathic. In such cases, management is difficult, especially when multiple teeth are involved. The aim of the present study was to assess the literature regarding the medical, clinical, and radiographic aspects of multiple idiopathic resorptions (MIR) and to examine the factors associated with the risk of extraction. Methods: The title and protocol were registered a priori in PROSPERO (CRD42020191564), and the study followed the PRISMA methodology. Four electronic databases were searched to include reviews and case reports on MIR in permanent dentition. Results: Among the 1035 articles identified, 31 case reports were included. The mean age of the patients was 32 years (SD = 16.4). MIR were consistently diagnosed after radiographic evaluation and were undetected during intra-oral examination in 62% of cases. The treatment involved extraction in 77% of cases. The risk of extraction increased in the presence of periodontal inflammation. Conclusions: MIR are aggressive forms of resorption requiring routine visits. MIR mostly involve extraction and lead to a challenging prosthetic rehabilitation due to severely damaged abutment teeth. However, the current knowledge on MIR remains fragmental and based on a limited number of case reports.

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“…The cementoenamel junction (CEJ) may possess a possible gap between the enamel and cementum and expose underlying the dentin to periodontal ligaments. The CEJ is a main portal of entry for human multiple idiopathic cervical root resorption featured by massive non-in ammatory resorptive lacunae 3,4 . In mouse models, the lack of Bsp (Bsp −/− ) or the Col1a1-conditional deletion of Alpl in selected dental cells have the common de ciency at the cervical cementum 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity

Choi

Liu

et al. 2022

Preprint

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Tooth roots embedded in the alveolar bone do not typically undergo resorption while the bone continues remodeling in its physiological state. In this study, we analyzed genetically modified mice with the functional inactivation of nucleotide pyrophosphatase 1 (Npp1), encoded by ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1). This mutation leads to the formation of ectopic cervical cementum vulnerable to external tooth root resorption. Cementoblasts with the inactivation of Enpp1 extensively expressed non-collagenous matrix proteins enriched with bone sialoprotein (Bsp), dentin matrix protein 1 (Dmp1), and osteopontin (Opn), which have roles in mineralization through nucleation and in cell adhesion through the Arg-Gly-Asp (RGD) motif. In cementoblasts with the inactivation of Enpp1, β-catenin was significantly activated and induced the expression of these non-collagenous matrix proteins. In addition, adenosine triphosphate (ATP), which is the most preferred substrate of Npp1, accumulated extracellularly and autocrinally induced the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cementoblasts with inactivated Npp1. Consequently, these results strongly suggest that functional Npp1 preserves thin and less-mineralized cementum integrity and supports the anti-resorptive properties of tooth roots through ATP homeostasis in the physiological state of cervical cementum.

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Multiple idiopathic cervical root resorption involving all permanent teeth

Cited by 14 publications

References 24 publications

External cervical resorption—a review of pathogenesis and potential predisposing factors

External cervical resorption—a review of pathogenesis and potential predisposing factors

The Medical, Clinical, and Radiographic Aspects of Multiple Idiopathic Tooth Resorption: A Systematic Review

Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity

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