Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions

Spinillo, Arsenio; Bello, Barbara Dal; Gardella, Barbara; Roccio, Marianna; Daccò, Maria Diletta; Silini, Enrico Maria

doi:10.1016/j.ygyno.2008.12.037

Cited by 62 publications

(62 citation statements)

References 22 publications

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“…Double-genotype infections accounted for 72.22% of all multiple infections and were the most common scenario in multiple infections. Spinillo et al (2009) found that multiple-genotype HPV infections could lead to the progression of cervical lesions. The risk of disease progression tripled with multiple-high-risk genotype infections compared to single-high-risk genotype infections.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China

Wang

Xing

et al. 2016

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate human papilloma virus (HPV) genotypes among women with cervical lesions in Shaanxi Province, China, to obtain information regarding cervical lesion prevention and treatment. The study included 4508 HPV-positive subjects; cervical swab specimens were collected and tested for HPV infection status and HPV genotypes using polymerase chain reaction and reverse dot-blot hybridization. Women positive for HPV with cervical lesions, including chronic cervicitis, cervical intraepithelial neoplasia, and cervical squamous cell carcinoma (SCC), were examined; HPV-positive women with no cervical lesions were controls. Data were pooled and weighted estimates have been presented. For women with no cervical lesions and positive for one HPV genotype, HPV 52, 16, 58, 81, 33, and 56 were the most common; for multiple-HPV genotype infection, HPV 16, 52, 6, 18, 58, and 66 were the most common. Collectively, HPV 16, 58, 52, 18, 33, and 81 were the most common in women with cervical lesions. HPV 16 comprised 26.71% of single-genotype and 15.64% of multiple-genotype infections. The proportion of HPV-16-positive cases was 29.15%, which was the highest among all HPV genotypes (P < 0.01). Single-HPV genotype infection was the most common in cervical HPV infection (77.48%); infection with two HPV genotypes comprised 72.22% of multiple-genotype infections. The proportion of single-low-risk HPV genotype infections decreased with increase in cervical lesion severity; there were no single-or multiple-lowrisk genotype HPV infections in cervical SCC patients. The proportion of multiple-genotype HPV infections with at least one high-risk genotype increased with cervical lesion severity.

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Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China

Wang

Xing

et al. 2016

Genet. Mol. Res.

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“…Some investigators found a positive relationship between multiple HPV type infection and progression of CIN. 30 However, other investigators could not find a relationship between multiple HPV type infection and CIN or cervical cancer. 16,31 In the current study, multiple high-risk HPV type infection was not related to progression to CIN3þ (data are not shown).…”

Section: Infectious Causes Of Cancermentioning

confidence: 98%

Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women

Hosaka

Fujita

Hanley

et al. 2012

Intl Journal of Cancer

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We examined incidence probabilities of cervical intraepithelial neoplasia 3 (CIN3) or more severe lesions (CIN3+) in 1,467 adult Japanese women with abnormal cytology in relation to seven common human papillomavirus (HPV) infections (16/18/31/33/35/52/58) between April 2000 and March 2008. Sixty‐seven patients with multiple HPV infection were excluded from the risk factor analysis. Incidence of CIN3+ in 1,400 patients including 68 with ASCUS, 969 with low grade squamous intraepithelial lesion (LSIL), 132 with HSIL without histology‐proven CIN2 (HSIL/CIN2(−)) and 231 with HSIL with histology‐proven CIN2 (HSIL/CIN2(+)) was investigated. In both high grade squamous intraepithelial lesion (HSIL)/CIN2(−) and HSIL/CIN2(+), HPV16/18/33 was associated with a significantly earlier and higher incidence of CIN3+ than HPV31/35/52/58 (p = 0.049 and p = 0.0060, respectively). This association was also observed in LSIL (p = 0.0002). The 1‐year cumulative incidence rate (CIR) of CIN3+ in HSIL/CIN2(−) and HSIL/CIN2(+) according to HPV genotypes (16/18/33 vs. 31/35/52/58) were 27.1% vs. 7.5% and 46.6% vs. 19.2%, respectively. In contrast, progression of HSIL/CIN2(+) to CIN3+ was infrequent when HPV DNA was undetected: 0% of 1‐year CIR and 8.1% of 5‐year CIR. All cervical cancer occurred in HSIL cases of seven high‐risk HPVs (11/198) but not in cases of other HPV or undetectable/negative‐HPV (0/165) (p = 0.0013). In conclusion, incidence of CIN3+ depends on HPV genotypes, severity of cytological abnormalities and histology of CIN2. HSIL/CIN2(+) associated with HPV16/18/33 may justify early therapeutic intervention, while HSIL/CIN2(−) harboring these HPV genotypes needs close observation to detect incidence of CIN3+. A therapeutic intervention is not indicated for CIN2 without HPV DNA.

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“…A higher prevalence of multiple types in LSIL was noticed, with 31.4%, 12.1% in those with ASC-US cytologies and 10.9% in those with negative cytologies; said findings agree with the study by Brismar-Wendel et al, 2009, where a higher percentage of multiple infections was noticed in patients with LSIL than those with ASC-US. Another study, as that of Spinillo et al, 2009, found however a significant increase of high grade CIN in patients with infections by multiple types of HPV, comparing with patients with single infections. They also verified that younger patients had more infections by multiple viral types.…”

Section: Discussionmentioning

confidence: 91%

Expression of Messenger RNA of Oncoproteins E6 and E7 of Human Papilomavirus in Women with Negative Oncotic Cytologies, Epithelial Squamous Atypias of Undefined Significance and Low-Grade Intraepithelial Lesions

Casagrande¹,

Ribalta²,

Leite³

et al. 2015

OJOG

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Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions

Cited by 62 publications

References 22 publications

Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China

Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China

Incidence risk of cervical intraepithelial neoplasia 3 or more severe lesions is a function of human papillomavirus genotypes and severity of cytological and histological abnormalities in adult Japanese women

Expression of Messenger RNA of Oncoproteins E6 and E7 of Human Papilomavirus in Women with Negative Oncotic Cytologies, Epithelial Squamous Atypias of Undefined Significance and Low-Grade Intraepithelial Lesions

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