Multiple HPV-Induced Squamous Cell Carcinomas on the Fingers of a Patient with Systemic Lupus Erythematosus: A Case and Review

Abstract

Human papilloma virus (HPV) infection is documented to be involved in the development of epithelial malignancies, mostly in cervical cancer. Systemic lupus erythematosus (SLE) patients have an increased prevalence of such an infection. We report the case of a 55-year-old female SLE patient who developed multiple in situ squamous cell carcinomas on her fingers, after chronic HPV infection. HPV-33 DNA was isolated from the lesions. The purpose of this case presentation is to raise awareness about HPV-induced malignancies for this high-risk group and propose an early HPV vaccination to efficiently prevent such comorbidities.

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

“…A total of 45 polydactylous cases were identified through the literature review, including the 1 case seen by the authors in the clinic (Table 1). 4,6 -38 There was a clear male predominance with 73.9% of cases reported in males and 23.9% reported in females ( P < .005). The age range at diagnosis was 21-80 years, with a mean age of 48.7 years.…”

Estudo de imunogenicidade da vacina HPV em pacientes com lúpus eritematoso sistêmico juvenil e dermatomiosite juvenil

“…Nenhum fator de risco foi encontrado que possa ter influenciado na não resposta a vacina. O vírus papiloma humano (HPV) é um vírus sexualmente transmissível, e a sua infecção é considerada o principal fator de risco para desenvolvimento de carcinoma de colo de útero, sendo também associado a tumores de pênis, ânus, boca e garganta (NIKOLAKIS et al, 2015). Considerada uma das Doenças sexualmente transmissíveis (DST) mais comuns do mundo, sua maior prevalência como infecção única, ou com infecção com vários subtipos de HPV foi constatada em adolescentes sexualmente ativas, assim como em mulheres jovens e portadoras de deficiência imunológica (WALBOOMERS et al, 1999) Em GARCÍA-CARRANCÁ, 2009).…”