Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups

Abstract

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients and more than 5000 controls using a PCR-based sequence-specific oligonucleotide probe hybridization approach. HLA-A68 and HLA-DR11 (5) were significantly increased in the cHL patient population compared with the controls. Three class II associations were observed in the EBV ؊ cHL population with an increase of HLA-DR15 (2) and a decrease of HLA-DR4 and HLA-DR7. Allele frequencies of HLA-A1, HLA-B37, and HLA-DR10 were significantly increased in the EBV ؉ cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in whites. The allele frequency of HLA-A2 was significantly decreased in the EBV ؉ cHL population. Sequencespecific oligonucleotide probe analysis revealed significant differences between EBV ؉ and EBV ؊ cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV ؉ cHL. Furthermore, several new protective and predisposing HLA class I and II associations for the EBV ؉ , the EBV ؊ , and the entire cHL population were identified. (Blood. 2011;118(19):5211-5217)

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32

“…20 The SNPs occur on 2 mirror haplotypes that are significantly associated with NSHL risk, and at least 1 may be linked to a reported protective HLA allele. 32 Because of the limitations of the association study design and the strong LD in the For personal use only. on May 11, 2018.…”

Environmental risk factors and genetic markers of Kaposi's sarcoma‐associated herpesvirus infection among Uygur population in Xinjiang, China

“…Like most other pathogens, susceptibility to KSHV infection might be caused by virus‐host environment interactions 5–7 . The human leukocyte antigen ( HLA ) complex plays a crucial role in controlling the immune response to viral infections, and variability in HLA has been shown to influence susceptibility or resistance to a range of viral infections, including HIV, human papillomavirus, Epstein‐Barr virus, and KSHV, but the conclusion is not yet clear 8–11 . The identified susceptible/resistant alleles mainly include both HLA class I and II, which have been summarized in our previous review 12 .…”

“…[5][6][7] The human leukocyte antigen (HLA) complex plays a crucial role in controlling the immune response to viral infections, and variability in HLA has been shown to influence susceptibility or resistance to a range of viral infections, including HIV, human papillomavirus, Epstein-Barr virus, and KSHV, but the conclusion is not yet clear. [8][9][10][11] The identified susceptible/resistant alleles mainly include both HLA class I and II, which have been summarized in our previous review. 12 At present, the majority of studies on the association between HLA polymorphisms and KSHV/KS risk have been conducted in Europe and Africa.…”