Multiple Hereditary Infundibulocystic Basal Cell Carcinomas

Requena, Luis; Fariña, María del Carmen; Robledo, Mercedes; Sangüeza, Omar P.; Yus, Evaristo Sánchez; Villanueva, Aurora; Marquina, A; Tamarit, Roser

doi:10.1001/archderm.135.10.1227

Cited by 74 publications

(49 citation statements)

References 38 publications

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“…Unlike infundibulocystic BCC, BFH is a superficial malformation of hair follicles with basaloid cords and strands seen only at the sites where normal follicles should be present, with no proliferations of basaloid neoplastic aggregations in interfollicular dermis and no involvement of deep reticular dermis. On the other hand, infundibulocystic BCC is a malignant neoplasm composed of aggregations of neoplastic cells that involve and destroy pre‐existing hair follicles and interfollicular dermis, and occasionally infiltrate deeper dermis, subcutaneous fat and skeletal muscles 17,18 …”

Section: Discussionmentioning

confidence: 99%

Basaloid follicular hamartoma

et al. 2005

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Basaloid follicular hamartoma (BFH) is a unique benign follicular hamartoma characterized by variable clinical presentations, identical histologic features and possible associations with numerous disorders. Basaloid follicular hamartoma may be hereditary or acquired. Hereditary cases may be either generalized or unilateral nevoid. Although the generalized forms are usually associated with systemic manifestations, such as myasthenia gravis,(2) it may occasionally present without internal disorders. On the other hand, the acquired forms of BFH may present in the form of localized or solitary forms. Herein we present four cases of BFH, one of them (first case) represents a unique form of the generalized variant of BFH, showing no associated internal disorders.

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Section: Discussionmentioning

confidence: 99%

Basaloid follicular hamartoma

et al. 2005

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“…Histopathological similarities exist between BFH and ICBCC, whereas there are several points of distinction between them. Requena et al [14]proposed clear-cut histopathological and clinical criteria to distinguish BFH from ICBCC and TE. They listed several key points for the differentiation.…”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinomas in Association with Basaloid Follicular Hamartoma

et al. 2003

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We describe a unique case of various types of basal cell carcinoma (BCC) associated with basaloid follicular hamartoma (BFH) in a 56-year-old female patient. The lesion consisted of a dark brown and elastic soft nodule and papules within the area of a birthmark on the neck. The lesion was surgically excised. Histological examination of the nodular region revealed aggregations of neoplastic basaloid cells. We diagnosed the nodule as BCC with a racemiform or reticular pattern. In addition, a specimen taken from brownish black papules within the birthmark was found to be composed of anastomosing cords of basaloid cells accompanied by infundibular cystic structures. These features were consistent with an infundibulocystic BCC. In contrast, specimens from a hamartomatous plaque showed distinctive branching strands of basaloid cells that are suggestive of BFH. Therefore, our findings indicate that several types of BCC may develop within a BFH.

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“…In addition, the follicles may or may not be connected to the epidermis, and peripheral palisading of basaloid cells can be present but less prominent than in basal cell carcinoma. Neither pleomorphism nor mitotic activity is seen5. On immunohistochemical staining, the outermost basal cells in BFH stain positive for Bcl-2, and stromal cells next to tumor cells stain positive for CD34.…”

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confidence: 86%

“…These features help differentiate BFH from basal cell carcinoma, especially infundibulocystic type, in that this presents with deeper infiltration, strong nuclear positivity for Ki-67, negativity for CD34, and prominent cytoplasmic positivity for Bcl-2. Other differential diagnoses include trichoepithelioma, which shows more abundant and highly fibrocytic stroma, and frequently involves follicular bulbs and papillae5.…”

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confidence: 99%