1999
DOI: 10.1001/archderm.135.10.1227
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Multiple Hereditary Infundibulocystic Basal Cell Carcinomas

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Cited by 76 publications
(49 citation statements)
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“…Unlike infundibulocystic BCC, BFH is a superficial malformation of hair follicles with basaloid cords and strands seen only at the sites where normal follicles should be present, with no proliferations of basaloid neoplastic aggregations in interfollicular dermis and no involvement of deep reticular dermis. On the other hand, infundibulocystic BCC is a malignant neoplasm composed of aggregations of neoplastic cells that involve and destroy pre‐existing hair follicles and interfollicular dermis, and occasionally infiltrate deeper dermis, subcutaneous fat and skeletal muscles 17,18 …”
Section: Discussionmentioning
confidence: 99%
“…Unlike infundibulocystic BCC, BFH is a superficial malformation of hair follicles with basaloid cords and strands seen only at the sites where normal follicles should be present, with no proliferations of basaloid neoplastic aggregations in interfollicular dermis and no involvement of deep reticular dermis. On the other hand, infundibulocystic BCC is a malignant neoplasm composed of aggregations of neoplastic cells that involve and destroy pre‐existing hair follicles and interfollicular dermis, and occasionally infiltrate deeper dermis, subcutaneous fat and skeletal muscles 17,18 …”
Section: Discussionmentioning
confidence: 99%
“…Histopathological similarities exist between BFH and ICBCC, whereas there are several points of distinction between them. Requena et al [14]proposed clear-cut histopathological and clinical criteria to distinguish BFH from ICBCC and TE. They listed several key points for the differentiation.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the follicles may or may not be connected to the epidermis, and peripheral palisading of basaloid cells can be present but less prominent than in basal cell carcinoma. Neither pleomorphism nor mitotic activity is seen5. On immunohistochemical staining, the outermost basal cells in BFH stain positive for Bcl-2, and stromal cells next to tumor cells stain positive for CD34.…”
mentioning
confidence: 86%
“…These features help differentiate BFH from basal cell carcinoma, especially infundibulocystic type, in that this presents with deeper infiltration, strong nuclear positivity for Ki-67, negativity for CD34, and prominent cytoplasmic positivity for Bcl-2. Other differential diagnoses include trichoepithelioma, which shows more abundant and highly fibrocytic stroma, and frequently involves follicular bulbs and papillae5.…”
mentioning
confidence: 99%