Multiple Genetic Mechanisms for the Evolution of Senescence in Drosophila melanogaster

Service, Philip M.; Hutchinson, E. W.; Rose, Michael R.

doi:10.2307/2408862

Cited by 111 publications

(86 citation statements)

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“…This gene-environment effect results in substantial reductions in life span and may have artifactually confounded several previous experimental attempts at selecting for increased life span in Drosophila that failed (Lints and Hoste, 1974;Lints et a!., 1978;Flannagan, 1980). It has been independently verified by Service et al (1988).…”

Section: Introductionmentioning

confidence: 71%

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

et al. 1990

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Different polymorphic elements of the enzyme glucose-6-phosphate dehydrogenase (G6PD) are favoured under selection for long versus short life span. Replicate independently selected populations of short-lived individuals exhibit a more rapidly migrating and less actively staining allozyme, while long-lived populations have a slower migrating and more active allozyme. These correspond to the common ZwA and ZwB variants of the G6PD locus Zw. In vitro measurements show G6PD activity varies with allozymes and life span. Long-lived males have 64 per cent greater activity in G6PD, while females of long-lived strains are 108 per cent higher than those of short-lived strains. Previous studies of these strains have repeatedly demonstrated additivity of life span in F1 crosses. Activity of G6PD in reciprocal F1 populations is additive and intermediate between parents.

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Section: Introductionmentioning

confidence: 71%

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

et al. 1990

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“…Several other studies have focused on the mutation accumulation theory (Rose & Charlesworth, 198 la;Service et a!., 1988). Kosuda (1985) found that male mating ability in Drosophila had larger variances in later ages, and the relative mating ability of the second chromosomal homozygotes as compared to the heterozygotes decreased considerably in later ages.…”

Section: Discussionmentioning

confidence: 99%

A genetic mechanism for the evolution of senescence in Callosobruchus chinensis (the azuki bean weevil)

Tanaka

1993

Heredity

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Heritabilities and genetic correlations of life-history characters (age-specific fecundities and longevity) in azuki bean weevils were estimated. Heritability estimates were moderate or high for longevity and several age-specific fecundities including early fecundity. A genetic correlation was highly negative between longevity and early fecundity. The negative genetic correlation supports the antagonistic pleiotropy theory for the evolution of senescence.Inbreeding depression for age-specific fecundities was assayed by comparing full-sib mated inbred lines and crosses. There was no tendency for inbreeding depression of fecundities to increase with age. The stability of inbreeding depression at different ages argues against the hypothesis that deleterious mutations accumulated in later ages are one of the causal factors for the evolution of senescence in this insect.

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“…Quantitative genetic studies have revealed over the past decade that patterns of pleiotropy are pervasive and unpredictable among characters at all levels of organismal analysis. For example, replicated strains selected for late-life fecundity in various laboratories exhibit correlated increases in longevity and flight endurance (Rose 1984b;Luckinbill et al 1988) as well as stress resistance traits such as ethanol, desiccation, and starvation resistance (Service et al , 1988. These same strains show declines in early-life fecundity (Rose 1984b), early-life male competitive mating ability (Service 1993), and early-life metabolic rate (Service 1987).…”

Section: Interspecific Patterns Due To Evolution Of the Genetic Backgmentioning

confidence: 99%

What does the Comparative Method Reveal About Adaptation?

Leroi¹,

Rose²,

Lauder³

1994

The American Naturalist

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201

141

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Abstract. -It has been suggested recently that new quantitative methods for analyzing comparative data permit the identification of evolutionary processes. Specifically, it has been proposed that new comparative methods can distinguish the direct effects of natural selection on the distribution of a trait within a clade from the effects of drift, indirect selection, genotype-byenvironment interaction, and uncontrolled environmental variation. Such methods can supposedly unravel t-he relative importance of these factors by the phylogenetic analysis of traits, performance attributes, and habitats. We argue that they cannot. We show that many different evolutionary mechanisms can, in principle, account for any one interspecific pattern, and we illustrate our case using examples from the comparative literature. We argue that these confounded mechanisms can only be unraveled if patterns of selection or genetic variation and covariation are directly measured in many species within a clade. Even though comparative methods are valuable for examining the evolutionary history of traits, they will often mislead in the study of adaptive processes.

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Multiple Genetic Mechanisms for the Evolution of Senescence in Drosophila melanogaster

Cited by 111 publications

References 0 publications

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster

A genetic mechanism for the evolution of senescence in Callosobruchus chinensis (the azuki bean weevil)

What does the Comparative Method Reveal About Adaptation?

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