Multiple gastrointestinal stromal tumors in a patient with type I neurofibromatosis presenting with tumor rupture and peritonitis

Ku, Ming-Chang; Tsai, Chun-Chou; Tyan, Yeu–Sheng

doi:10.1016/j.clinimag.2009.03.005

Cited by 8 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The case of a perforated GIST in the jejunum, as presented in this instance, is notably rare. Such cases have been sporadically reported in the English medical literature, underscoring their unusual occurrence (Table 1) [4,6,[12][13][14][15][16][17][18][19]. Note: ANED-alive with no evidence of disease; SR-surgical resection; HPF-high power field; N/A-not available.…”

Section: Discussionmentioning

confidence: 99%

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

Mirovic,

Stojanovic,

Jovanovic

et al. 2024

CIMB

View full text Add to dashboard Cite

This case report details a rare instance of a perforated jejunal gastrointestinal stromal tumor (GIST) in a 76-year-old female patient. The patient presented with acute abdominal pain and distension without any changes in bowel habits or episodes of nausea and vomiting. Initial diagnostics, including abdominal plain radiography and ultrasonography, were inconclusive; however, a computed tomography (CT) scan revealed pneumoperitoneum and an irregular fluid collection suggestive of small intestine perforations. Surgical intervention uncovered a 35 mm jejunal GIST with a 10 mm perforation. Histopathological examination confirmed a mixed cell type GIST with high malignancy potential, further substantiated by immunohistochemistry markers CD117, DOG1, and vimentin. Molecular analysis illuminated the role of key oncogenes, primarily KIT and PDGFRA mutations, emphasizing the importance of molecular diagnostics in GIST management. Despite the severity of the presentation, the patient’s postoperative recovery was favorable, highlighting the effectiveness of prompt surgical and multidisciplinary approaches in managing complex GIST cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

Mirovic,

Stojanovic,

Jovanovic

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…The patient's presentation of a perforated GIST of jejunum is rare. A few cases have been reported in the English medical literature associated with the perforation of GIST in the jejunum (Table 2) (7)(8)(9)(10)(11)(12). It is important to note that a GIST expresses the c-kit (CD117) oncoprotein which is a mutated receptor of tyrosine kinase (13).…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

Mirovic¹,

Stojanovic

Stanković

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal system and it accounts for between 1-3% of all gastrointestinal malignancies. GIST arises most commonly from the stomach in 60 – 70% of cases. The clinical presentation of acute abdomen, due to GIST perforation, was a particularly rare described complication of this disease. Our case report aimed to present a case of acute abdomen in an elderly female patient, due to jejunal GIST perforation. Case presentation: A 76-year-old female patient presented with acute abdomen to the emergency surgical unit University Clinical Center of Kragujevac. Computed tomography (CT) scan with intravenous contrast showed pneumoperitoneum, the presence of a 75 x 35 mm irregular fluid collection in the left lower quadrant of the abdomen with air inclusions and signs of small intestine perforations. The patient underwent an emergency laparotomy. Intraoperative findings showed the acute inflammatory reaction of the peritoneum with free bowel contents in the abdominal cavity due to jejunal tumor perforation. Partial resection of the small intestine with tumor was performed followed by intestine anastomosis. Histopathological examination of a specimen revealed a completed resected jejunal gastrointestinal stromal tumor. CONCLUSIONS: GIST arises from the small intestine in 25-30% of cases, and jejunum in 10% of cases. Perforation of GIST and acute diffuse peritoneal inflammation was rare complication of the disease. Emergency laparotomy and complete resection of tumors are essential.

show abstract

“…However GIST perforation seems to occur more frequently in the small bowel compared to other anatomic sites [35] . Our literature search revealed 21 cases of acute abdomen with diffuse or localized peritonitis caused by spontaneous perforation of small intestine GISTs ( Table 1 ) [9–29] . Two more cases are reported in the case-series of Mansour and Coll [8] .…”

Section: Discussionmentioning

confidence: 99%

“…Few GISTs manifest as abdominal emergencies, such as GI haemorrhage, intestinal obstruction, or tumour perforation [7,8] . Although acute abdomen due to GIST perforation into the peritoneal cavity is rare, a few cases of peritonitis caused by perforation of small-intestinal GISTs have been reported in the literature [8–29] . Together with a review of the published cases, here we report a case of an elderly patient with acute abdomen due to spontaneous perforation of a GIST located in the jejunum.…”

Section: Introductionmentioning

confidence: 99%

Peritonitis secondary to spontaneous perforation of a primary gastrointestinal stromal tumour of the small intestine: A case report and a literature review

Alessiani

Gianola²,

Rossi

et al. 2015

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

HighlightsEmergency presentation of a GIST is not uncommon and one of its manifestations is acute abdome.The cases described in the literature are the tip of the iceberg and spontaneous rupture or perforation of GISTs are a far more frequent first presentation of this rare tumour.The jejunum was the more common location of perforation compared to the ileum.Emergency surgery is mandatory and should achieve radical resection.

show abstract

Multiple gastrointestinal stromal tumors in a patient with type I neurofibromatosis presenting with tumor rupture and peritonitis

Cited by 8 publications

References 11 publications

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

A Rare Case of Acute Abdomen Caused by Perforation of Jejunal Gastrointestinal Stromal Tumor (Gist): A Case Report and Literature Review

Peritonitis secondary to spontaneous perforation of a primary gastrointestinal stromal tumour of the small intestine: A case report and a literature review

Contact Info

Product

Resources

About