Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Pecenova, L.; Farkas, Róbert

doi:10.1515/enr-2016-0019

Cited by 5 publications

(5 citation statements)

References 157 publications

(134 reference statements)

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“…Notably, the 7 most abundant TFs detected have all been shown to interact with nuclear receptors (13)(14)(15)(16)(17)(18), except for max1, though it is a binding partner of myc (19). Additionally, Myc, BLHLE40, max, and TCF12 are members of the basic-helix-loophelix (bHLH) family of nuclear receptor coactivators (20). Interestingly, when these genes were categorized according to how many regulatory elements (TF binding sites, enhancers, open chromatin), they had within ± 5 kb of the ChIP-seq binding site, the majority had either none or only 1 ( Figure 2C).…”

Section: Resultsmentioning

confidence: 99%

Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling

Zhou¹,

Mehta²,

Srivastava³

et al. 2020

JCI Insight

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Section: Resultsmentioning

confidence: 99%

Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling

Zhou¹,

Mehta²,

Srivastava³

et al. 2020

JCI Insight

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“…In addition to differences in metabolism and binding affinity, different chemicals may influence the interactions of the AHR with cofactor proteins that influence intracellular signaling pathways 22 , 72 . This is a common feature of nuclear receptors, and contributes to modifications to cellular events downstream of their engagement 73 , 74 . For example, the AHR has been shown to interact with subunits of the nuclear factor kappa b (NF-κB) complex in myeloid cells, B cells, and fibroblasts 75 – 77 , although the precise NF-κB family members with which AHR interacts varied among cell types.…”

Section: Discussionmentioning

confidence: 99%

Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome

Boule

Burke

Jin

et al. 2018

Sci Rep

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The aryl hydrocarbon receptor (AHR) offers a compelling target to modulate the immune system. AHR agonists alter adaptive immune responses, but the consequences differ across studies. We report here the comparison of four agents representing different sources of AHR ligands in mice infected with influenza A virus (IAV): TCDD, prototype exogenous AHR agonist; PCB126, pollutant with documented human exposure; ITE, novel pharmaceutical; and FICZ, degradation product of tryptophan. All four compounds diminished virus-specific IgM levels and increased the proportion of regulatory T cells. TCDD, PCB126 and ITE, but not FICZ, reduced virus-specific IgG levels and CD8 + T cell responses. Similarly, ITE, PCB126, and TCDD reduced Th1 and Tfh cells, whereas FICZ increased their frequency. In Cyp1a1-deficient mice, all compounds, including FICZ, reduced the response to IAV. Conditional Ahr knockout mice revealed that all four compounds require AHR within hematopoietic cells. Thus, differences in the immune response to IAV likely reflect variances in quality, magnitude, and duration of AHR signaling. This indicates that binding affinity and metabolism may be stronger predictors of immune effects than a compound's source of origin, and that harnessing AHR will require finding a balance between dampening immune-mediated pathologies and maintaining sufficient host defenses against infection.There is considerable evidence that signaling through the aryl hydrocarbon receptor (AHR) alters the course of adaptive immune responses in a manner that can be protective or detrimental. Adaptive immune responses underlie host protection from pathogens, but when improperly controlled they contribute to numerous diseases. The AHR's remarkable capacity to modulate T cell responses has been demonstrated in autoimmune diseases 1-5 , allergic inflammation 6,7 , and inflammatory bowel diseases [8][9][10] . Yet, these reports also suggest that different AHR ligands may bias adaptive immune responses in opposite directions, and that exposure to the same ligand can worsen or improve pathology in different disease models 1,2,11 . While these issues remain to be resolved, the ability of the AHR to modulate T cell differentiation and T cell-dependent immune responses has generated enthusiasm about targeting therapeutic agents at the AHR in order to modulate the progression of a large spectrum of immune-mediated diseases 12,13 .Yet, there is another aspect of AHR immunobiology that has direct bearing on the potential success of new strategies to use AHR ligands as treatment modalities: the impact on host responses to infection. Several reports demonstrate the importance of AHR in sensing microbes, including pathogenic and commensal bacteria, mycobacteria, and fungi [14][15][16][17] . Epidemiological studies show strong correlations between exposure to anthropogenically-derived AHR ligands from the environment and increased incidence and severity of respiratory infections, most notably viral infections 18,19 . These observations have been extended with a...

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“…Besides, it also consists of protein–protein interaction domain that assists oligomerization between TFs or with other regulators (Padi and Quackenbush, 2015; Boeva, 2016). Many TFs have been recognized by X-ray crystallography and Nuclear Magnetic Resonance spectroscopy (Dantas Machado et al, 2014; Pecenova and Farkas, 2016). TFs families can be evolved in many ways such as exon capture, duplication, translocation and mutation (Edger and Pires, 2009; Sharma et al, 2013).…”

Section: Tfs For Gene Regulation In Plantmentioning

confidence: 99%

MicroRNA and Transcription Factor: Key Players in Plant Regulatory Network

et al. 2017

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Recent achievements in plant microRNA (miRNA), a large class of small and non-coding RNAs, are very exciting. A wide array of techniques involving forward genetic, molecular cloning, bioinformatic analysis, and the latest technology, deep sequencing have greatly advanced miRNA discovery. A tiny miRNA sequence has the ability to target single/multiple mRNA targets. Most of the miRNA targets are transcription factors (TFs) which have paramount importance in regulating the plant growth and development. Various families of TFs, which have regulated a range of regulatory networks, may assist plants to grow under normal and stress environmental conditions. This present review focuses on the regulatory relationships between miRNAs and different families of TFs like; NF-Y, MYB, AP2, TCP, WRKY, NAC, GRF, and SPL. For instance NF-Y play important role during drought tolerance and flower development, MYB are involved in signal transduction and biosynthesis of secondary metabolites, AP2 regulate the floral development and nodule formation, TCP direct leaf development and growth hormones signaling. WRKY have known roles in multiple stress tolerances, NAC regulate lateral root formation, GRF are involved in root growth, flower, and seed development, and SPL regulate plant transition from juvenile to adult. We also studied the relation between miRNAs and TFs by consolidating the research findings from different plant species which will help plant scientists in understanding the mechanism of action and interaction between these regulators in the plant growth and development under normal and stress environmental conditions.

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Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family

Cited by 5 publications

References 157 publications

Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling

Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling

Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome

MicroRNA and Transcription Factor: Key Players in Plant Regulatory Network

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