Multiple function of lncRNA MALAT1 in cancer occurrence and progression

Malakoti, Faezeh; Targhazeh, Niloufar; Karimzadeh, Haniye; Mohammadi, Erfan; Asadi, Milad; Asemi, Zatollah; Alemi, Forough

doi:10.1111/cbdd.14006

Cited by 16 publications

(7 citation statements)

References 221 publications

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“…We analyzed the significance of two target lncRNAs levels between two groups using the t test ( P < 0.01). The lncRNAs MALAT1 and HOTAIR levels in NSCLC patients are significantly higher than those in healthy persons ( t test, P < 0.01, Figure B), which agrees well with the elevated expression of lncRNAs MALAT1 and HOTAIR in NSCLC patients. , This assay was further validated by qRT-PCR (Figure C,D), whose results are consistent with those obtained by the proposed assay (Figure A,B), suggesting the capability of this method to precisely distinguish NSCLC patients from healthy persons with high accuracy.…”

Section: Resultssupporting

confidence: 84%

Programmable Ligation-Transcription Circuit-Driven Cascade Amplification Machinery for Multiple Long Noncoding RNAs Detection in Lung Tissues

Zhang

Liu

et al. 2022

Anal. Chem.

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The measurement of long noncoding RNAs (lncRNAs) is essential to diagnosis and treatment of various diseases such as cancers. Herein, we develop a simple method to simultaneously detect multiple lncRNAs using programmable ligation-transcription circuit-driven cascade amplification and single-molecule counting. The presence of targets lncRNA HOTAIR and lncRNA MALAT1 activates the ligation-transcription circuits to produce two corresponding functional RNAs. The functional RNAs then cyclically initiate the digestion of signal probes by duplex-specific nuclease to liberate Cy5 and Cy3 molecules. After magnetic separation, the liberated Cy5 and Cy3 molecules are measured by single-molecule counting. In this assay, a single lncRNA can activate ligation-transcription circuit to generate abundant functional RNAs, endowing this assay with high sensitivity. Integration of single-molecule counting ensures the high sensitivity. This method shows extremely high sensitivity with a limit of detection (LOD) of 0.043 aM for HOX gene antisense intergenic RNA (lncRNA HOTAIR) and 0.126 aM for mammalian metastasis-related lung adenocarcinoma transcript 1 (lncRNA MALAT1). Importantly, this method enables simultaneous measurement of multiple endogenous lncRNAs at the single-cell level, and it may discriminate the expressions of various lncRNA in lung tumor tissues of nonsmall cell lung cancer (NSCLC) patients and their corresponding healthy adjacent tissues, offering a promising platform for clinical diagnosis and biomedical research.

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Section: Resultssupporting

confidence: 84%

Programmable Ligation-Transcription Circuit-Driven Cascade Amplification Machinery for Multiple Long Noncoding RNAs Detection in Lung Tissues

Zhang

Liu

et al. 2022

Anal. Chem.

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“…Further study shows that MALAT1 may competitively interact with DBC1, resulting in SIRT1 release, p53 deacetylation, cell proliferation, and inhibition of cell apoptosis ( 29 ). The roles of MALAT1 in cancer cells have been reviewed ( 30 ). Knockdown or overexpression of MALAT1 under different pathophysiological conditions exhibits substantial transcriptional changes ( Figure 1 ).…”

Section: The Biological Activities Of Malat1mentioning

confidence: 99%

The regulatory activities of MALAT1 in the development of bone and cartilage diseases

2022

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Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is involved in the differentiation, proliferation, and apoptosis of multiple cell lines, including BMSCs, osteoblasts, osteoclasts, and chondrocytes. Interestingly, MALAT1 may interact with RNAs or proteins, regulating cellular processes. Recently, MALAT1 has been reported to be associated with the development of bone and cartilage diseases by orchestrating the signaling network. The involvement of MALAT1 in the pathological development of bone and cartilage diseases makes it available to be a potential biomarker for clinical diagnosis or prognosis. Although the potential mechanisms of MALAT1 in mediating the cellular processes of bone and cartilage diseases are still needed for further elucidation, MALAT1 shows great promise for drug development.

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“…LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been known to be correlated with tumor metastasis in human cancer ( 119 ). MALAT1 expression was linked to the WHO grade, tumor size and poor survival in glioma patients ( 120 ).…”

Section: Lncrnas Regulate the Expression Of F-box Proteinsmentioning

confidence: 99%

The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression

et al. 2022

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Accumulated evidence has revealed that F-box protein, a subunit of SCF E3 ubiquitin ligase complexes, participates in carcinogenesis and tumor progression via targeting its substrates for ubiquitination and degradation. F-box proteins could be regulated by cellular signaling pathways and noncoding RNAs in tumorigenesis. Long noncoding RNA (lncRNA), one type of noncoding RNAs, has been identified to modulate the expression of F-box proteins and contribute to oncogenesis. In this review, we summarize the role and mechanisms of multiple lncRNAs in regulating F-box proteins in tumorigenesis, including lncRNAs SLC7A11-AS1, MT1JP, TUG1, FER1L4, TTN-AS1, CASC2, MALAT1, TINCR, PCGEM1, linc01436, linc00494, GATA6-AS1, and ODIR1. Moreover, we discuss that targeting these lncRNAs could be helpful for treating cancer via modulating F-box protein expression. We hope our review can stimulate the research on exploration of molecular insight into how F-box proteins are governed in carcinogenesis. Therefore, modulation of lncRNAs is a potential therapeutic strategy for cancer therapy via regulation of F-box proteins.

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Multiple function of lncRNA MALAT1 in cancer occurrence and progression

Cited by 16 publications

References 221 publications

Programmable Ligation-Transcription Circuit-Driven Cascade Amplification Machinery for Multiple Long Noncoding RNAs Detection in Lung Tissues

Programmable Ligation-Transcription Circuit-Driven Cascade Amplification Machinery for Multiple Long Noncoding RNAs Detection in Lung Tissues

The regulatory activities of MALAT1 in the development of bone and cartilage diseases

The functions of long noncoding RNAs on regulation of F-box proteins in tumorigenesis and progression

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