Multiple forms of α2u, a sex-dependent urinary protein of the adult male rat

Lane, Stanley E.; Neuhaus, Otto W.

doi:10.1016/0005-2795(72)90095-5

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…The polymorphic MUP genes serve as a specific genetic marker of individual identity (Zhou and Rui, 2010). MUP expression is sexually dimorphic and is higher in males (Geertzen et al, 1973; Lane and Neuhaus, 1972). Each individual adult male mouse normally secretes 8-14 different MUP isoforms, and this specific pattern of MUP isoforms serves as an individual identity signature (Zhou and Rui, 2010).…”

Section: Regulation Of Nutrient Metabolism By Other Lcn Family Memmentioning

confidence: 99%

Lipocalin 13 Regulation of Glucose and Lipid Metabolism in Obesity

Zhou

Rui

2013

Vitamins &Amp; Hormones

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Summary Lipocalin (LCN) family members are small secreted proteins that bind to small hydrophobic molecules via their characteristic central β-barrels. A couple of LCN family members, including major urinary protein 1 (MUP1), retinol-binding protein 4 (RBP4), LCN2, and LCN13, have been reported to regulate insulin sensitivity and nutrient metabolism. LCN13 is expressed by multiple tissues, including the liver, pancreas, epididymis, and skeletal muscle, and is secreted into the bloodstream in mice. Obesity is associated with a downregulation of LCN13 expression and lower levels of circulating LCN13. LCN13 therapies overcome LCN13 deficiency in mice with either genetic or dietary obesity, leading to an improvement in hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, and hepatic steatosis. In hepatocytes, LCN13 directly suppresses hepatic gluconeogenesis and lipogenesis but increases fatty acid β oxidation. LCN13 also enhances insulin sensitivity in adipocytes. The potential mechanisms of the anti-diabetes and anti-steatosis actions of LCN13 are discussed.

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Section: Regulation Of Nutrient Metabolism By Other Lcn Family Memmentioning

confidence: 99%

Lipocalin 13 Regulation of Glucose and Lipid Metabolism in Obesity

Zhou

Rui

2013

Vitamins &Amp; Hormones

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“…The MUP family members were initially discovered in urine as a group of small proteins with molecular weights around 18 kD (Finlayson et al, 1965; Lane and Neuhaus, 1972). MUPs are mainly synthesized in the liver and secreted into the bloodstream (Shaw et al, 1983).…”

Section: Mup Protein Structure and Polymorphismmentioning

confidence: 99%

“…MUP expression is sexually dimorphic in rodents, and the levels of MUPs are much higher in males than in females (Geertzen et al, 1973; Lane and Neuhaus, 1972). Androgen potently stimulates MUP expression, resulting in male-dominant expression and excretion of MUPs (Johnson et al, 1995; Kurtz and Feigelson, 1977).…”

Section: Mup Protein Structure and Polymorphismmentioning

confidence: 99%

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Major Urinary Protein Regulation of Chemical Communication and Nutrient Metabolism

Zhou

Rui

2010

Vitamins &Amp; Hormones

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Summary The major urinary protein (MUP) family members contain a conserved β-barrel structure with a characteristic central hydrophobic pocket. They are secreted by the liver and excreted into the urine. MUPs bind via their central pockets to volatile pheromones or other lipophilic molecules, and regulate pheromone transportation in the circulation, excretion in the kidney, and release into the air from urine marks. MUPs are highly polymorphic, and the MUP profiles in urine function as individual identity signatures of the owners. The MUP signatures are detected by the main and accessory olfactory systems and trigger adaptive behavioral responses and/or developmental processes. Circulating MUPs serve as a metabolic signal to regulate glucose and lipid metabolism. Recombinant MUP1 markedly ameliorates hyperglycemia and glucose intolerance in mice with type 2 diabetes. MUP1 suppresses hepatic gluconeogenesis and promotes energy expenditure in skeletal muscle by stimulating mitochondrial biogenesis and function. MUPs are unique members of the lipocalin super-family that mediate both chemical and metabolic signaling.

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“…This protein is synthesized in the liver, secreted into the blood stream, concentrated in the kidneys, and excreted in the urine. Its synthesis is under the synergistic control of androgens and glucocorticoids (3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: At(11-1)-1754 Coo-1754-12mentioning

confidence: 99%

Effects of whole-body $gamma$-irradiation on the biosynthesis of certain serum proteins. Progress report, September 1, 1972--December 31, 1973

Neuhaus¹

1973

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Multiple forms of α2u, a sex-dependent urinary protein of the adult male rat

Cited by 12 publications

References 11 publications

Lipocalin 13 Regulation of Glucose and Lipid Metabolism in Obesity

Lipocalin 13 Regulation of Glucose and Lipid Metabolism in Obesity

Major Urinary Protein Regulation of Chemical Communication and Nutrient Metabolism

Effects of whole-body $gamma$-irradiation on the biosynthesis of certain serum proteins. Progress report, September 1, 1972--December 31, 1973

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