Multiple Forms of the Cardiac Glycoside Receptor with Different Affinities for Cardiac Glycosides

Erdmann, Erland; Brown, Lindsay; Werdan, Karl; Berger, Hans

doi:10.1007/978-1-4613-2057-9_21

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1990

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“…This effect of T 4 in increasing membrane Na-K-ATPase activity has been well documented in a variety of species and tissue with respect to both enzyme activity and the number of sodium pump sites as judged by ouabain binding (15,29,30). The result of the present study shows that T 4 increased 86Rb-uptake which reflects Na-K-ATPase activity.…”

Section: Discussionsupporting

confidence: 75%

Thyroxine induces transition of red towards white muscle in cultured heart cells

Brik

Shainberg

1990

Basic Res Cardiol

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Thyroid hormones (TH) have previously been shown to alter the force and velocity of cardiac muscle contractions. To investigate the mechanism responsible for these alterations, excess amounts of thyroxine (T4, 1 microM) were applied on rat heart cells grown in cell culture. We found the following biochemical alterations: a) 40% decrease in the myoglobin content within 2 days; b) 25% increase in the rate of Ca-uptake into sacroplasmic reticulum (SR) in myocytes following chemical skinning; and c) a two-fold increase in Na-K-ATPase activity measured by 86Rb-uptake. These changes support our hypothesis that TH induce the transition of slow-twitch ("red") muscles towards the fast-twitch ("white") muscle type. This may explain the changes in contractile activity known to occur under TH influence.

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Section: Discussionsupporting

confidence: 75%