Multiple Focal Pure Ground-Glass Opacities on High-Resolution CT Images: Clinical Significance in Patients With Lung Cancer

Abstract

The size of most focal pure GGOs associated with lung cancer did not change during the follow-up period. Most of the small number of lesions histologically diagnosed were atypical adenomatous hyperplasia or bronchioloalveolar carcinoma. These data justify the therapeutic strategy of resecting the primary tumor without therapeutic intervention in the remaining focal pure GGOs.

Survival of a surgical series of lung cancer patients with synchronous multiple ground-glass opacities, and the management of their residual lesions

“…The 5-year OS and RFS proportions of our data were satisfactory and all the patients with multifocal pure GGOs remained alive for 5 years without recurrence, similarly to several previous studies [5,14,15].…”

“…Several studies addressing this topic have reported similar results, demonstrating a favorable prognosis [5,[12][13][14][15]. The 5-year OS and RFS proportions of our data were satisfactory and all the patients with multifocal pure GGOs remained alive for 5 years without recurrence, similarly to several previous studies [5,14,15].…”

Early lung cancer with lepidic pattern

“…However, at least one invasive focus measuring more than 5 mm in greatest dimension must be present. In a series of 39 patients with multifocal ground glass lesions and negative lymph nodes, Gu et al [35 & ] recently reported a 100% overall survival after anatomic resection of the dominant tumor and wedge resection of all other accessible ground glass opacities (GGO), which is in line with data from previous studies [36][37][38][39]. The average percentage of the lepidic pattern in LPA was recently reported to be 50% (range: 40-85%) with acinar (81%) and papillary (17%) as the predominant accompanying invasive components [26 && ].…”

Can CT imaging features of ground‐glass opacity predict invasiveness? A meta‐analysis

“…With developments in CT examination technology, such as the application of low‐dose mass screening and HRCT, GGO is now more commonly detected clinically . The five‐year survival rate has been reported at almost 100% for AAH, AIS, and MIA patients; however, the long‐term survival rate of patients with invasive adenocarcinoma remains poor .…”