Multiple Fibrofolliculomas With Trichodiscomas and Acrochordons

An Unusual Mass on the Skin of Scrotum: Acrochordon

“…In our case, lesion appeared six years ago and gradually grew. It is important to distinguish these lesions from the hamartomatous skin lesions (multiple fibrofolliculomas) associated with Birt-Hogg-Dubé syndrome, which are histologically distinct from common skin tags (5). The microscopical examination of fibroepitelial polyp involves squamous epithelium.…”

Multiple Fibrofolliculomas and Trichodiscomas

“…The disease seems to cover a spectrum of peculiar benign neopla sias ofthe hair follicle and the hair disk with different associated conditions. The typical lesion includes multiple cutaneous papular tumors, namely fibro folliculomas and trichodiscomas, associated with acrochordons [4][5][6][7], The majority of the reported cases arc members of families with an autosomal dominant mode of inher itance, although sporadic cases like ours have been reported [5], representing perhaps 'formes frustes' of the disease. Moreover, there arc cases reported as multiple familiar fibrofolliculomas [8], multiple familiar peri follicular fibromas [9], multiple fibrofollicu lomas with acrochordons [10], multiple trichodiscomas with acrochordons and perifollicular fibromas [2], multiple tricho discomas [II,12], and cases in which, in spite of histological demonstration of fibrofolliculomas and trichodiscomas, no acrochordons could be detected in the patients examined (cases 2 and 4 of Bahts et al [6], the present case).…”

Exclusion of PTEN, CTNNB1, and PTCH as candidate genes for Birt-Hogg-Dube syndrome

“…Since the initial report, other cases have been described. [2][3][4][5][6][7][8][9][10][11][12][13] The cutaneous manifestations of BHD, which typically appear during the third or fourth decade of life, have been associated with renal carcinoma, 2 5 spontaneous pneumothorax, 2 6 and colonic polyps. 3 4 Toro et al 2 recently reported three extended kindreds in whom renal neoplasms and BHD segregated together.…”