Multiple extraneural metastasis of glioblastoma multiforme

Undabeitia, José; Castle, M.; Arrazola, Mariano; Pendleton, Courtney; Ruiz, Inmaculada Fortes; Úrculo, E.

doi:10.23938/assn.0061

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…However, the survival time increased progressively with each decade from 1940 to 2000, which they attribute to the use of MRI. J. Undabeitia [ 9 ] also believes that the increase in the incidence of ECM is related to the improvement of medical treatment as a whole. Epidemiologically, younger, healthier patients appear to be more prone to extracranial metastases, most likely because of longer overall survival (OS) compared with older GBM patients with multiple chronic diseases [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Extracranial metastasis of glioblastoma: A case report and literature review

Gu,

Ding,

Zheng

et al. 2023

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Extracranial metastasis of glioblastoma: A case report and literature review

Gu,

Ding,

Zheng

et al. 2023

International Journal of Surgery Case Reports

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“…In a meta-analysis by Lun et al, 83 published cases of ECM from GBM were found in the period from 1928 to 2009 [ 2 ]. Increasing incidence of ECM has been suggested but possible explanations are increased interest among specialists, improved access to health care, improved neuroimaging, and advanced multimodal treatment of gliomas [ 2 , 7 ]. A meta-analysis by Anghileri et al supports the idea that prolonged survival of GBM patients is associated with greater risk of ECM and it is emphasized that this finding does not rule out the hypothesis that GBM subclones contribute to tumor cell dissemination [ 4 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature

Johansen

Rochat

Law

et al. 2016

Case Reports in Oncological Medicine

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Extracranial metastases from glioblastoma are rare. We report two patients with extracranial metastases from glioblastoma. Case 1 concerns a 59-year-old woman with multiple metastases that spread early in the course of disease. What makes this case unusual is that the tumor had grown into the falx close to the straight sinus and this might be an explanation to the early and extensive metastases. Case 2 presents a 60-year-old man with liver metastasis found at autopsy, and, in this case, it is more difficult to find an explanation. This patient had two spontaneous intracerebral bleeding incidents and extensive bleeding during acute surgery with tumor removal, which might have induced extracranial seeding. The cases presented might have hematogenous spreading in common as an explanation to extracranial metastases from GBM.

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“…Similarly, metastasis is rarely observed in gliomas. Both squamous cells carcinoma and gliomas are locally invasive and aggressive malignancies that rarely metastasize [117][118][119][120][121][122].…”

Section: Tumor Metastasismentioning

confidence: 99%

Reviewing cancer’s biology: an eclectic approach

Karidio

Şanlıer

2021

J Egypt Natl Canc Inst

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Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are commonly characterized by unrestricted cell proliferation and dysfunctional replicative senescence pathways. In fact, the cell cycle operates under the rigorous control of complex signaling pathways involving cyclins and cyclin-dependent kinases assumed to be specific to each phase of the cycle. At each of these checkpoints, the cell is checked essentially for its DNA integrity. Genetic defects observed in these molecules (i.e., cyclins, cyclin-dependent kinases) are common features of cancer cells. Nevertheless, each cancer is different concerning its molecular and cellular etiology. These could range from the genetic defects mechanisms and/or the environmental conditions favoring epigenetically harbored homeostasis driving tumorigenesis alongside with the intratumoral heterogeneity with respect to the model that the tumor follows. Conclusions This review is not meant to be an exhaustive interpretation of carcinogenesis but to summarize some basic features of the molecular etiology of cancer and the intratumoral heterogeneity models that eventually bolster anticancer drug resistance for a more efficient design of drug targeting the pitfalls of the models.

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Multiple extraneural metastasis of glioblastoma multiforme

Cited by 9 publications

References 12 publications

Extracranial metastasis of glioblastoma: A case report and literature review

Extracranial metastasis of glioblastoma: A case report and literature review

Presentation of Two Cases with Early Extracranial Metastases from Glioblastoma and Review of the Literature

Reviewing cancer’s biology: an eclectic approach

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