Multiple evanescent white dot syndrome following rabies vaccination: a case report

Yang, Jiasong; Chen, Chunli; Hu, Yaomin; Zhou, Rui

doi:10.1186/s12886-018-0968-y

Cited by 31 publications

(24 citation statements)

References 9 publications

(9 reference statements)

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“…[6] It is also noted that two cases of multiple evanescent white dot syndrome (MEWDS) have also been reported post human papilloma virus and rabies vaccination. [8,9] Giant cell arteritis (GCA) occurring after receiving the influenza vaccination has also been documented in previous studies. [10] Over the past decade, mRNA has become a promising tool in vaccine development.…”

Section: Discussionmentioning

confidence: 78%

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

Maleki

Look-Why

Manhapra

et al. 2021

JOVR

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Purpose: To report two cases; bilateral arteritic anterior ischemic optic neuropathy (AAION) and bilateral acute zonal occult outer retinopathy (AZOOR) after COVID-19 mRNA vaccination. Case Reports: The first patient was a 79-year-old female was presented to us 35 days after a sudden bilateral loss of vision, which occurred two days after receiving the second recombinant mRNA vaccine (Pfizer) injection. Temporal artery biopsy was compatible with AAION. At presentation, the best-corrected visual acuity was 20/1250 and 20/40 in the right and left eyes on the Snellen acuity chart, respectively. There was 3+ afferent pupillary defect in the right eye. The anterior segment and posterior segment exams were normal except for pallor of the optic nerve head in both eyes. Intraocular pressure was normal in both eyes. She was diagnosed with bilateral AAION and Subcutaneous tocilizumab 162 mg weekly was recommended with monitoring her ESR, CRP, and IL-6. The second patient was a 33-year-old healthy female who was referred to us for a progressive nasal field defect in her left eye, and for flashes in both eyes. Her symptoms started 10 days after receiving the second recombinant mRNA vaccine (Moderna) injection. Complete bloodwork performed by a uveitis specialist demonstrated high ESR (25) and CRP (19) levels. As a result, she was diagnosed with unilateral AZOOR in her left eye and was subsequently treated with an intravitreal dexamethasone implant in the same eye. At presentation, vision was20/20 in both eyes. The anterior segment and posterior segment exams were completely normal except for the presence of abnormal white reflex in the temporal macula of her left eye. We diagnosed her with bilateral AZOOR. Since she was nursing, intravitreal dexamethasone implant was recommended for the right eye. Conclusion: There may be a correlation between ocular inflammatory diseases with autoimmune mechanism and the mRNA COVID-19 vaccination.

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Section: Discussionmentioning

confidence: 78%

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

Maleki

Look-Why

Manhapra

et al. 2021

JOVR

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“…To the best of our knowledge, there have been eight published case of MEWDS following various vaccinations, including rabies, 7 human papilloma virus, 8 , 9 hepatitis A, 6 , 10 hepatitis B, 11 meningococcal, 8 Yellow fever, 6 and influenza. 4 , 5 The demographics and clinical course of all published cases.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, eight cases of vaccination-associated multiple evanescent white dot syndrome (MEWDS) have been reported previously. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 We add here the description of a ninth case of MEWDS following immunization with inactivated intra-dermal influenza virus, and include for the first time full multimodal imaging (MMI) of such a case. Characteristics and outcomes of all nine cases are summarized and compared.…”

Section: Introductionmentioning

confidence: 99%

Multiple evanescent white dot syndrome following influenza immunization - A multimodal imaging study

Jumper

Cunningham

2020

American Journal of Ophthalmology Case Reports

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Purpose To describe the multimodal imaging (MMI) findings and clinical course of a case of Multiple Evanescent White Dot Syndrome (MEWDS) following immunization with inactivated intra-dermal influenza virus, and to explore whether similarities exist with other, previously reported cases. Observations A 34-year-old Caucasian man presented with unilateral onset of para-central scotomata, photopsias, and dyschromatopsia two weeks after administration of an influenza vaccine. Clinical examination and MMI were indicative of MEWDS. The patient's MMI abnormalities and symptoms resolved spontaneously after four weeks. Conclusion and importance This is the first reported case of MMI of post-influenza vaccination-associated MEWDS. Comparison with eight previously reported cases of MEWDS following various immunizations revealed that subjects tended to be healthy, young to middle age women with a median time to onset of two weeks. Vision tended to recover spontaneously over one to three months.

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“…Research into possible viral causes precipitating MEWDS has been conducted, potentiating autoimmune origins [8]. While there have been several cases reported in the literature about the development of MEWDS following a variety of vaccine administrations [8][9][10][11], there have been no reports highlighting the clinical manifestation of MEWDS from hand-foot-and-mouth disease transmission, as we present here.…”

Section: Introductionmentioning

confidence: 89%

Multiple Evanescent White Dot Syndrome Presenting in Possibly Contracted Hand-Foot-and-Mouth Disease: A Rare Presentation

Ekanayake

Bhatnagar

Bucur

et al. 2019

Cureus

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Multiple evanescent white dot syndrome (MEWDS), an inflammatory retinal condition seen predominantly in young adult patients, is characterized by unilateral vision loss with variable scotomas. The etiology of MEWDS is currently elusive and the formal mechanism is unknown. However, it must be differentiated from other white dot syndromes (WDS). Fundus fluorescein angiography in MEWDS exhibits a “wreath-like” arrangement of hyperfluorescent lesions predominantly located in the outer retina. Herein we present a case of a 32-year-old Southeast Asian female who presented to the emergency department with peripheral blindness and central scotomas. The patient's daughter was diagnosed with hand-foot-and-mouth disease seven days earlier, which often presents as an extremely debilitating condition. Below, we elaborate on the etiology, pathogenesis, and diagnostic methods to elucidate the multifactorial causes of MEWDS and aid clinicians in diagnosis and treatment. Although associated with certain viral illnesses, to the best of our knowledge, there have been no reported cases of MEWDS in conjunction with hand-foot-and-mouth disease.

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Multiple evanescent white dot syndrome following rabies vaccination: a case report

Cited by 31 publications

References 9 publications

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence?

Multiple evanescent white dot syndrome following influenza immunization - A multimodal imaging study

Multiple Evanescent White Dot Syndrome Presenting in Possibly Contracted Hand-Foot-and-Mouth Disease: A Rare Presentation

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