Multiple Erythematous Papules in a Child with Neutropenia

Oh, Susan; Word, Andrew P.; Domínguez, Arturo R.

doi:10.1111/pde.12586

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The most common underlying disorder was acute lymphoblastic leukemia (ALL) (13/32; 41%) followed by acute myeloid leukemia (AML) (8/32 cases; 25%). The remaining 34% of the reported cases included three cases with aplastic anemia, two cases with mixed ALL and one case with Blackfan-Diamond, myelodysplastic syndrome (MDS), Langerhans cell histiocytosis, Wilms tumor, Ewing sarcoma and yolk sac tumor, respectively [38,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59]. The male/female ratio was 1/1.…”

Section: Malignant And/or Hematologic Disordersmentioning

confidence: 99%

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Kourti

Roilides

2022

Pathogens

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(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to T. asahii published since 1994, the year of the revised taxonomic classification. (3) Results: Twenty-four cases of invasive trichosporonosis were identified in neonates with the presence of central venous catheter and use of broad-spectrum antibiotics recognized as the main predisposing factors. Thirty-two cases were identified in children with malignancies or hematologic disorders, predominantly with severe neutropenia. Trichosporon asahii was isolated from blood in 24/32 (75%) pediatric cases. Cutaneous involvement was frequently observed in invasive trichosporonosis. Micafungin was the most commonly used prophylactic agent (9/22; 41%). Ten patients receiving prophylactic echinocandins were identified with breakthrough infections. A favorable outcome was reported in 12/16 (75%) pediatric patients receiving targeted monotherapy with voriconazole or combined with liposomal amphotericin B. Overall mortality in neonates and children with malignancy was 67% and 60%, respectively. (4) Conclusions: Voriconazole is advocated for the treatment of invasive trichosporonosis given the intrinsic resistance to echinocandins and poor susceptibility to polyenes.

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Section: Malignant And/or Hematologic Disordersmentioning

confidence: 99%

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Kourti

Roilides

2022

Pathogens

View full text Add to dashboard Cite

show abstract

“…The most common underlying disorder was acute lymphoblastic leukemia (ALL) (13/32; 41%) followed by acute myeloid leukemia (AML) (8/32 cases; 25%). The remaining 34% of the reported cases included 3 cases with aplastic anemia, 2 cases with mixed ALL and one case with Blackfan-Diamond, myelodysplastic syndrome, Langerhans cell histiocytosis, Wilms tumor, Ewing sarcoma and yolk sac tumor, respectively [40,[43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61]. The male/female ratio was 1/1.…”

Section: Malignant And/or Hematologic Disordersmentioning

confidence: 99%

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Kourti¹,

Roilides²

2022

Preprint

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(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to T. asahii published since 1994, year of the revised taxonomic classification. (3) Results: Twenty-four cases of invasive trichosporonosis were identified in neonates with presence of central venous catheter and use of broad-spectrum antibiotics recognized as main predisposing factors. Thirty-two cases were identified in children with malignancies or hematologic disorders, predominantly with severe neutropenia. Trichosporon asahii was isolated from blood in 24/32 (75%) pediatric cases. Cutaneous involvement was frequently observed in invasive trichosporonosis. Micafungin was the most commonly used prophylactic agent (9/22; 41%). Ten patients receiving prophylactic echinocandins were identified with breakthrough infections. Favorable outcome was reported in 12/16 (75%) pediatric patients receiving targeted monotherapy with voriconazole or combined with liposomal amphotericin B. Overall mortality in neonates and children with malignancy was 67% and 60%, respectively. (4) Conclusions: Voriconazole is advocated for the treatment of invasive trichosporonosis given the intrinsic resistance to echinocandins and poor susceptibility to polyenes.

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Antineoplastics/hydrocortisone

2015

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Multiple Erythematous Papules in a Child with Neutropenia

Cited by 5 publications

References 11 publications

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Antineoplastics/hydrocortisone

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