Multiple eruptive dermatofibromas occurring in a patient with acute myeloid leukaemia

Chang, Sung‐Eun; Choi, Jae-Hyeog; Sung, Kyung Jeh; Moon, Kee Chan; Koh, Jai‐Kyoung

doi:10.1046/j.1365-2133.2000.03508.x

Cited by 23 publications

(20 citation statements)

References 7 publications

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“…It occurs most often as a solitary lesion in otherwise healthy persons. MEDFs are rare and have been reported in association with autoimmune and neoplastic diseases, with and without immunosuppressive treatment, HIV infections and other conditions, including hydronephrosis, diabetes, hypercholesterolemia, obesity, atopic dermatitis and pregnancy [1, 2, 3, 4, 5]. These conditions affect the immune status, suggesting that altered immunity may play a role in the pathogenesis of MEDF [1, 3].…”

Section: Discussionmentioning

confidence: 99%

“…It most often occurs as a solitary lesion in otherwise healthy persons. Multiple eruptive dermatofibromas (MEDFs) are rare and have been thought to be associated with altered immunity [1, 2, 3, 4, 5]. It has been reported that dermatofibrosarcoma protuberans (DFSP) is positive for CD34 but not for factor X IIIa, whereas DF is positive for factor X IIIa but not for CD34 [6, 7, 8, 9].…”

Section: Introductionmentioning

confidence: 99%

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Multiple Eruptive Dermatofibromas with CD34+ Cells in a Patient with Hypertriglyceridemia

et al. 2003

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Multiple eruptive dermatofibromas (MEDF) are rare and have been thought to be associated with altered immunity. It has been reported that dermatofibromas (DFs) are positive for factor X IIIa but not for CD34. In this report, we describe a 34-year-old Japanese woman with MEDF and persistent hypertriglyceridemia. Histopathological examination revealed that several areas in larger nodules, showing higher cellularity and storiform growth pattern, had CD34+ cells. Our case and the review of previous reports suggest that hyperlipidemia, including hypertriglyceridemia, could induce MEDF and that highly cellular areas in DFs are sometimes positive for CD34.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple Eruptive Dermatofibromas with CD34+ Cells in a Patient with Hypertriglyceridemia

et al. 2003

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“…MEDF usually occurs in immunocompromised patients with HIV infection or receiving an immunosuppressive drug therapy [11, 12, 13, 14, 15], making its clinical and/or pathological distinction from KS challenging [16]. We present a patient with MEDF who showed no clinical and laboratory signs of immunodeficiency but was seropositive for HHV-8 antibodies and demonstrated HHV-8 DNA both in his blood and lesional skin.…”

Section: Introductionmentioning

confidence: 99%

HHV-8 DNA Sequences in the Peripheral Blood and Skin Lesions of an HIV-Negative Patient with Multiple Eruptive Dermatofibromas: Implications for the Detection of HHV-8 as a Diagnostic Marker for Kaposi’s Sarcoma

Kazakov

Schmid²,

Adams³

et al. 2003

Dermatology

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Background: Multiple eruptive dermatofibroma (MEDF) is a rare disorder seen in immunocompromised patients, simulating Kaposi’s sarcoma (KS). Whereas KS is strongly associated with human herpesvirus 8 (HHV-8), the virus has never been detected in MEDF until now. Objective: To present a patient with MEDF who showed no signs of immunodeficiency but was seropositive for HHV-8 antibodies and demonstrated HHV-8 DNA both in the peripheral blood and lesional skin of MEDF. Methods: Clinical, histological and serological investigations were performed as well as polymerase chain reaction (PCR) studies and in situhybridization (ISH). Results: A 35-year-old white man with suspected KS was referred for evaluation of multiple pigmented nodules and patches. Biopsies revealed features of dermatofibroma, superficial fibrosing dermatitis and scar. One of the nodular lesions harbored HHV-8 DNA sequences. A faint amplification product was detected in the superficial fibrosing dermatitis lesion, while no HHV-8 sequences were found in normal skin and scar. Whole-blood samples and serum were positive for HHV-8. None of the skin lesions shown to harbor HHV-8 DNA sequences by nested PCR displayed a signal for HHV-8 RNA by ISH. Repetitive peripheral blood examinations did not reveal any serum antibodies against or antigens of HIV. Serum antibodies against the HHV-8 capsid antigen orf 65.2 were detected. Conclusion: Results of PCR studies and ISH indicate that the presence of HHV-8 in the lesional tissue was probably blood-borne due to viremia and not due to viral replication in tumor cells. The presence of HHV-8 is not fully restricted to KS. The differential diagnosis of KS and its simulators should be based on an integrative analysis of all available clinicopathological and molecular data and should not rely exclusively or predominantly on the presence or absence of HHV-8.

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“…The occurrence of multiple eruptive DF (MEDF) is rare. Since the initial observation of Cohen 1 of the association among MEDFs, autoimmune diseases, and immunosuppressive therapy, MEDFs have been associated with autoimmune diseases, 1-14 immunosuppressant therapy, 1,2,[4][5][6][7][8][9][10][11]13,14 HIV infection, 8,[15][16][17][18][19][20][21] hematologic malignancy, [22][23][24] pregnancy, 25 and other conditions. MEDFs may be related to the altered immune status of these conditions, although the pathogenesis is uncertain.…”

mentioning

confidence: 99%

Multiple eruptive dermatofibromas in a patient with dermatomyositis taking prednisolone and methotrexate

Huang

Chu

Hsiao

2007

Journal of the American Academy of Dermatology

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Multiple eruptive dermatofibromas occurring in a patient with acute myeloid leukaemia

Cited by 23 publications

References 7 publications

Multiple Eruptive Dermatofibromas with CD34+ Cells in a Patient with Hypertriglyceridemia

Multiple Eruptive Dermatofibromas with CD34+ Cells in a Patient with Hypertriglyceridemia

HHV-8 DNA Sequences in the Peripheral Blood and Skin Lesions of an HIV-Negative Patient with Multiple Eruptive Dermatofibromas: Implications for the Detection of HHV-8 as a Diagnostic Marker for Kaposi’s Sarcoma

Multiple eruptive dermatofibromas in a patient with dermatomyositis taking prednisolone and methotrexate

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