Multiple eruptive dermatofibromas

Zaouak, Anissa; Chamli, Amal; Khanchel, Fatma; Fenniche, Samy

doi:10.1016/j.lpm.2019.09.002

Cited by 4 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dermatofibroma has been assumed to be a reactive process due to the persistent proliferation of fibroblasts following trauma [3]. This hypothesis is supported by our study [5, 71–73]. However, multiple DFs have been strongly associated with an underlying disease.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Multiple dermatofibromas (DFs) are rare benign fibrohistiocytic lesions characterized by asymptomatic hyperpigmented nodules. Several diseases, like systemic lupus erythematosus (SLE) and human immunodeficiency virus (HIV) infection, are found to be associated with multiple DFs. Here, we designed a systematic review by an electronic search of PubMed and Embase databases to select case reports of multiple DFs (29 May 2021). From 2,145 initially found articles, 96 studies (106 cases) were included. We classified multiple DFs (>1 DF lesion) into four subtypes and separately investigated clinical characteristics of each one: multiple eruptive DFs (MEDFs) (n = 45), multiple (n = 41), multiple clustered DFs (MCDFs) (n = 18), and giant combined (n = 2). The patients’ mean age was 38.3 ± 14.7 years. The majority were female (61.3 %). The lesions were commonly on the trunk and extremities (36.8 %). MEDFs (n = 36) had the most rapid disease onset (2.0 ± 6.6 years). Immunosuppression induced by either HIV (10.3 %) and hematologic malignancy (9.4 %) or immunosuppressive drugs (23.4 %) along with SLE (19.8 %) were the most observed associations. However, 66.7 % of the MCDF patients were otherwise healthy individuals. As for disease management, surgery and follow‐up were the preferred options. Most of the cases showed neither resolution nor development of new lesions in follow‐up.

show abstract

Section: Discussionsupporting

confidence: 83%

“…Full‐texts of 11 articles were not accessible and 30 articles were irrelevant after assessing the full‐text. Eventually, 96 studies fulfilled the eligibility criteria and were included [1–96] (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“…Es wird angenommen, dass es sich beim Dermatofibrom um einen reaktiven Prozess aufgrund der dauerhaften Proliferation von Fibroblasten nach einem Trauma handelt [3]. Diese Hypothese wird durch unsere Studie unterstützt [5, 71–73]. Allerdings wurden multiple DF stark mit einer zugrundeliegenden Erkrankung assoziiert.…”

Section: Diskussionunclassified

“…Die Volltexte von 11 Artikeln waren nicht zugänglich und 30 Artikel stellten sich nach Lesen des Volltexts als irrelevant heraus. Schließlich erfüllten 96 Studien die Eignungskriterien und wurden eingeschlossen [1–96] (Abbildung 1).…”

Section: Ergebnisseunclassified

Klinische und histologische Charakteristika bei multiplen Dermatofibromen: Eine systematische Übersicht

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Zusammenfassung Multiple Dermatofibrome (DF) sind seltene gutartige fibrohistiozytäre Läsionen, die durch asymptomatische hyperpigmentierte Knoten charakterisiert sind. Mehrere Erkrankungen wie systemischer Lupus erythematodes (SLE) und Infektionen mit dem humanen Immundefizienz‐Virus (HIV) sind mit multiplen DF assoziiert. Hier haben wir eine systematische Übersicht anhand einer elektronischen Recherche der Datenbanken PubMed und Embase konzipiert, um Fallberichte zu multiplen DF auszuwählen (29. Mai 2021). Von den 2145 ursprünglich gefundenen Artikeln wurden 96 Studien (106 Fälle) eingeschlossen. Multiple DF (> 1 DF‐Läsion) wurden in vier Subtypen eingeteilt und für jeden Subtyp wurden die klinischen Charakteristika separat untersucht: multiple eruptive DF (MEDF) (n = 45), multiple DF (n = 41), multiple gruppierte DF (MCDF) (n = 18) und große kombinierte DF (n = 2). Das Durchschnittsalter der Patienten betrug 38,3 ± 14,7 Jahre. Die Mehrzahl waren Frauen (61,3 %). Die Läsionen befanden sich häufig am Stamm und an den Extremitäten (36,8 %). MEDF (n = 36) hatten den schnellsten Krankheitsbeginn (2,0 ± 6,6 Jahre). Neben SLE (19,8 %) war eine durch HIV (10,3 %), maligne hämatologische Erkrankungen (9,4 %) oder Immunsuppressiva (23,4 %) induzierte Immunsuppression die am häufigsten beobachtete Assoziation. Allerdings waren 66,7 % der MCDF‐Patienten ansonsten gesund. Hinsichtlich des Managements der Erkrankung waren Operation und Nachkontrolle die bevorzugten Optionen. Bei den meisten Fällen trat während der Nachkontrolle weder eine Abheilung noch eine Entwicklung neuer Läsionen auf.

show abstract

Multiple Eruptive Dermatofibroma: A Case Report

Yao,

Wang,

Zhou

2024

CCID

View full text Add to dashboard Cite

Background: Multiple eruptive dermatofibroma (MEDF) is a rare presentation of dermatofibroma which is frequently associated with underlying diseases such as human immunodeficiency virus infection or systemic lupus erythematosus. It generally presents a characteristic histology with hyperplasia of the epidermis, prominent bundles of collagen and a diffuse proliferation of fibrocytes. Case Summary: We report a case of MEDF in a 30-year-old man who presented with a large number of dark brownish red maculopapules distributed over the trunk and extremities for more than 10 years. According to the pathology, the patient was diagnosed with MEDF. Infections and autoimmune diseases were ruled out. As he had no clinical symptoms, and presented with lesions widely distributed over the body, we gave no special treatment, but suggested a regular examination. Conclusion: Patients with MEDF usually have no pain and pruritus. If human immunodeficiency virus infection and systemic lupus erythematosus and other causes are ruled out, and lesions are widely distributed over the body, regular check-up is recommended without specific treatment.

show abstract

Multiple eruptive dermatofibromas

Cited by 4 publications

References 3 publications

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Klinische und histologische Charakteristika bei multiplen Dermatofibromen: Eine systematische Übersicht

Multiple Eruptive Dermatofibroma: A Case Report

Contact Info

Product

Resources

About