Cell Reports volume 5, issue 1, P137-150 2013 DOI: 10.1016/j.celrep.2013.09.002 View full text
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Saskia Delpretti, Thomas Montavon, Marion Leleu, Elisabeth Joye, Athanasia Tzika, Michel Milinkovitch, Denis Duboule

Abstract: Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opposite long noncoding RNAs (lncRNAs), Hotdog and Twin of Hotdog, selectively contacts the expressed Hoxd genes in the framework of a topological domain, coinciding with robust transcription of thes…

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