Multiple endocrine neoplasia type IIb

Macken, Peter; Francis, Ian C.; Leung, Betty; Hooper, Michael J.; Vicary, D. J.; Whitehouse, Geoffrey M.

doi:10.1111/j.1442-9071.1990.tb00619.x

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1992

2004

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“…Those that have been frequently reported in patients with MEN2B are: prominent corneal nerves, thickening of the eyelids and subconjunctival neuromas. A smaller number of reports have described anterior displacement of the cilia 8−21 . All of the above features were identified in the current series.…”

Section: Discussionmentioning

confidence: 50%

External ophthalmic findings in multiple endocrine neoplasia type 2B

Parker¹,

Robinson

O’Donnell³

2004

Clinical Exper Ophthalmology

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Ptosis and lower lid margin eversion are previously unreported findings in patients with MEN2B. Medullary thyroid carcinoma is the most serious consequence of MEN2B and has a high mortality if untreated. Early diagnosis and prophylactic thyroidectomy may be lifesaving. Gene mutations can be identified but the sporadic tendency of the syndrome emphasizes the importance of early clinical detection. MEN2B is one of a number of systemic malignancies with ophthalmic manifestations. Ophthalmologists should be aware of the external features of this rare but lethal malignancy.

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Section: Discussionmentioning

confidence: 50%