Multiple Endocrine Neoplasia Type 1 Involving Both Liver and Lung: A Case Report

Abstract

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant tumor syndrome with a high degree of heterogeneity in clinical phenotypes, generally involving parathyroid, anterior pituitary and enteropancreas. In recent years, several new insights on the clinical features of MEN1 have been reported in the literature. However, it is not clear whether MEN1-associated primary tumors may occur in the liver. Case presentation: we report the case of a 52-year-old man with multiple endocrine neoplasia type 1 diagnosed by next-generation sequencing. After Single-hole thoracoscopic right middle lobectomy, Laparoscopic radical resection of liver tumor and Radiofrequency ablation of parathyroid space, the parathyroid hormone decreased from 177pg/ml to normal(20pg/ml). No local tumor recurrence was observed during a follow up of 5 months. Conclusion: We report the first case of MEN1 with simultaneous liver and lung involvement who underwent radical resection of the tumors, and we propose the possibility that liver and other non-endocrine organs may also develop diseases associated with MEN1，though this view needs further verification. Gene detection has crucial clinical instructive significance for diagnosis and treatment.