Multiple Effects of Preeclampsia in Cows on Postnatal Growth and Health of Offspring

Chernitskiy, Anton; Shabunin, S. V.; Сафонов, В. А.

doi:10.15389/agrobiology.2019.2.246eng

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Указанные выше показатели крови определяли с помощью унифицированных методов и коммерческих наборов реактивов «ДиаВет Тест» (АО «Диакон-ДС», Россия). Помимо этого, изучали уровень маркеров эндогенной интоксикации: сорбционная способность эритроцитов (ССЭ), содержание молекул средней массы на длинах волн 237 (МСМ 237 ) и 254 (МСМ 254 ) нм [2]. Используя авторскую методику [3], оценивали состояние рецепторов локализованных на мембранах эритроцитов.…”

Section: Biology and Biotechnologiesunclassified

Indicators of the autonomic nervous system and endotoxemia in cows with physiological and pregnancy complicated by gestosis

Popova,

Parshin,

Alehin

2023

Agrarian Bulletin of The

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The purpose of the study was to study the state of the autonomic nervous system and the level of endogenous intoxication markers in animals during pregnancy, physiological and complicated by gestosis and toxic liver dystrophy (hepatosis) and their combination. Materials and methods were used in accordance with the assigned tasks. In the conditions of two farms specializing in the production of milk and located in the Belgorod and Pskov regions, studies were conducted, the object of which were cows of the Red-and-White and Holstein Black-and-White breeds at the age of 3–6 years with a gestational age of 240–250 days. As a result of experimental tests, it was revealed that in cows with moderate gestosis, in addition to traditional hypertension, proteinuria and edema, there is an increase in heart rate variability, tachycardia, hypersympathicotonia, neutrophilocytosis, lymphocytopenia and resorptive endotoxication. With a combination of gestosis and hepatosis, the appearance of new (integral) and strengthening of pathophysiological phenomena specific to each of these pathologies is observed. As a result, a symptom complex of severe pathology is formed with bradycardia, vagotonia, resorptive and metabolic endogenous intoxication, leukogram imbalance with a predominance of young cells, monocytopenia, eosinopenia, more pronounced neutrophilocytosis and lymphocytopenia, as well as a decrease in adaptive potential. The scientific novelty lies in the fact that, according to the data obtained, one of the directions of the progression of preeclampsia (gestosis) may be the development of comorbid pathology. At the same time, the deterioration of the animal's condition is a consequence of the aggravation of each of the associated pathologies and the formation of integral pathogenetic integration in the body. In this case, the choice of therapies should be focused on eliminating or alleviating the manifestation of gestosis and associated pathologies, as well as on leveling the pathogenetic mechanisms of comorbidity.

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Section: Biology and Biotechnologiesunclassified

Indicators of the autonomic nervous system and endotoxemia in cows with physiological and pregnancy complicated by gestosis

Popova,

Parshin,

Alehin

2023

Agrarian Bulletin of The

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“…В подавляющем большинстве случаев поздний токсикоз беременности клинически проявляется в 6-7 месяцев беременности. По мнению большинства исследователей гестоз начинает развиваться в более ранние сроки, но не имеет клинического проявления [5,6].…”

Section: введение / Introductionunclassified

Evaluation of the possibility of using indicators of the blood coagulation system of cows to predict late toxicosis of pregnant women

Mikhalev,

Chusova

2023

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Indicators of the blood coagulation system (thrombin time, prothrombin time, activated partial thromboplastin time - aPTT) were studied on 42 pregnant cows at 60-75, 135-150 and 210-230 days of pregnancy, divided according to the principle of analogues into three groups: physiological course, fetal growth restriction syndrome without late toxicosis of pregnancy, fetal growth restriction syndrome complicated by gestosis. Pregnancy was diagnosed using transrectal and ultrasound examinations. Fetal growth restriction syndrome was diagnosed at 60-75 days of pregnancy using an ultrasound scanner with a linear sensor with a frequency of 7.5 MHz. Late toxicosis of pregnant animals was diagnosed at 210-230 days of pregnancy by the presence of hypertension, proteinuria and edema. Blood samples were taken from the animals included in the experiment to determine the platelet content, thrombin and prothrombin time and aPTT. It has been established that platelet content is an informative indicator for predicting gestosis in the first five months of pregnancy with a sensitivity of 80.0% and specificity of 87.5%. The sensitivity of thrombin time at 60-150 days of pregnancy is 77.8%, specificity - 90.0%, prothrombin time - 70.0 and 88.9%, aPTT at 135-150 days of pregnancy - 77.8 and 85.7%, respectively. Prognostic markers for early diagnosis of late toxicosis in pregnant animals, determined at 2 months of pregnancy are: platelet level - 451.2 x 109/L and higher; thrombin time – 87.3 seconds and below; prothrombin time – 35.1 seconds and below. Indicators for early diagnosis of gestosis, determined at 5 months of pregnancy, are: platelet level - 437.5 x 109/L and higher; thrombin time – 78.6 seconds and below; prothrombin time – 30.3 seconds and below; aPTT – 41.8 sec and below.

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Placenta-Based Biologically Active Preparation on the Condition of the LPO-AOP in the Prevention of Obstetric Pathology in Cows

Ventsova

2022

Agriculture Digitalization and Organic Production

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Multiple Effects of Preeclampsia in Cows on Postnatal Growth and Health of Offspring

Cited by 3 publications

References 19 publications

Indicators of the autonomic nervous system and endotoxemia in cows with physiological and pregnancy complicated by gestosis

Indicators of the autonomic nervous system and endotoxemia in cows with physiological and pregnancy complicated by gestosis

Evaluation of the possibility of using indicators of the blood coagulation system of cows to predict late toxicosis of pregnant women

Placenta-Based Biologically Active Preparation on the Condition of the LPO-AOP in the Prevention of Obstetric Pathology in Cows

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