Multiple effects of childhood deafness on cortical activity in children receiving bilateral cochlear implants simultaneously

Gordon, Karen A.; Tanaka, Sho; Wong, Daniel; Stockley, Tracy L.; Ramsden, James D.; Brown, Trecia A.; Jewell, Stephanie; Papsin, Blake C.

doi:10.1016/j.clinph.2010.10.037

Cited by 26 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Averaged peak-to-peak amplitude of this type of responses ranged from 2.08 to 5.29 μV, which is similar to those measured in pediatric and adult CI users (e.g. Brown et al, 2008, 2015; Firszt et al, 2002; Gordon et al, 2005, 2011; Sharma et al, 2002, 2009). Type 1 responses accounted for 76% of total responses recorded in the present study.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

McFayden

Teagle

et al. 2016

Ear &Amp; Hearing

View full text Add to dashboard Cite

Objective This study aimed to 1) characterize morphological characteristics of the electrically-evoked cortical auditory event-related potentials (eERP) and explore the potential association between onset eERP morphology and auditory vs non-auditory stimulation; 2) assess test-retest reliability of onset eERPs; 3) investigate effects of stimulation level on onset eERPs; and 4) explore the feasibility of using the onset eERP to estimate the lowest stimulation level that can be detected for individual stimulating electrodes in patients with auditory brainstem implants (ABIs). Design Study participants included five children (S1-S5) and two adults (S6-S7) with unilateral Cochlear Nucleus 24M ABIs. Pediatric ABI recipients ranged in age from 2.6 to 10.2 years (mean: 5.2 years) at the time of testing. S6 and S7 were 21.2 and 24.6 years of age at the time of testing, respectively. S6 and S7 were diagnosed with neurofibromatosis II (NF2) and implanted with an ABI after a surgical removal of the tumors. All pediatric subjects received ABIs after being diagnosed with cochlear nerve deficiency. The lowest stimulation level that could be detected (behavioral T level) and the estimated maximum comfortable level (C level) was measured for individual electrodes using clinical procedures. For electrophysiological measures, the stimulus was a 100-ms biphasic pulse train that was delivered to individual electrodes in a monopolar-coupled stimulation mode at stimulation levels ranging from sub-threshold to C levels. Electrophysiological recordings of the onset eERP were obtained in all subjects. For studies evaluating the test-retest reliability of the onset eERP, responses were measured using the same set of parameters in two test sessions. The time interval between test sessions ranged from two to six months. The lowest stimulation level that could evoke the onset eERP was defined as the objective T level. Results Onset eERPs were recorded in all subjects tested in this study. Inter- and intra-subject variations in morphological characteristics of onset eERPs were observed. Onset eERPs with complex waveforms were recorded for electrodes that evoked non-auditory sensations, based on feedback from subjects, as well as for electrodes without any indications of non-auditory stimulations. Onset eERPs in patients with ABIs demonstrated good test-retest reliability. Increasing stimulation levels resulted in increased eERP amplitudes but showed inconsistent effects on response latencies in patients with ABIs. Objective and behavioral T levels were correlated. Conclusions eERPs could be recorded in both non-NF2 and NF2 patients with ABIs. eERPs in both ABI patient groups show inter- and intra-subject variations in morphological characteristics. However, onset eERPs measured within the same subject in this study tended to be stable across study sessions. The onset eERP can potentially be used to estimate behavioral T levels in patients with ABIs. Further studies with more adult ABI recipients are warranted to investigate whether th...

show abstract

Section: Discussionsupporting

confidence: 78%

“…Averaged maximum peak-to-peak amplitude of this response was 24.28 μV, which is larger than what has been reported for onset eERPs measured in CI users (e.g. Brown et al, 2008, 2015; First et al, 2002; Gordon et al, 2005, 2011; Sharma et al, 2002, 2009). Neural generators for onset eERPs recorded in ABI patients remain unknown.…”

Section: Discussioncontrasting

confidence: 65%

Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

McFayden

Teagle

et al. 2016

Ear &Amp; Hearing

View full text Add to dashboard Cite

show abstract

“…Similarly, changes in the bilateral auditory cortex following implantation have been observed in deaf cats (Kral et al, 2002). However, differences exist between adults and children regarding the changes in the contralateral and the ipsilateral auditory cortex after unilateral implantation, and cortical development within the group of CI children seems to be highly heterogeneous (Gordon et al, 2011;Nash-Kille and Sharma, 2014). Our results suggest no hemispheric differences for postlingually deafened adult CI recipients, whereas for CI children stronger cortical changes in the contralateral than in the ipsilateral auditory cortex have been reported (Gordon et al, 2013).…”

Section: Remarkable Changes In the Contralateral And Ipsilateral Audimentioning

confidence: 95%

Rapid bilateral improvement in auditory cortex activity in postlingually deafened adults following cochlear implantation

Sandmann

Plotz

Hauthal

et al. 2015

Clinical Neurophysiology

View full text Add to dashboard Cite

“…Even when profound hearing loss is identified at birth, we do not know whether the child had any access to sound or to spontaneous auditory activity in utero. In a recent study (Gordon et al 2010a), we found that cortical responses evoked by acute cochlear implant stimulation (apical electrode) were highly variable in a large cohort of children (n = 72) who, on average, had limited durations of deafness and received bilateral cochlear implants simultaneously. Figure 7 shows responses evoked by the along with the grandmean waveform (thick black lines).…”

Section: Multiple Effects Of Deafness On Cortical Activity In Childrementioning

confidence: 98%

“…Moreover, the etiology of deafness remains unknown in most affected children. Numerous genetic mutations have now been associated with hearing loss but the most common, explaining 20% of our population of children receiving cochlear implants (Propst et al 2006b;Gordon et al 2010a), are changes to the GJB-2 gene on chromosome 13 which cause depletion of the Connexin 26 protein. This protein is essential to gap junctions in the supporting cells of the organ of Corti which work to maintain high concentrations of potassium in the scala media and which are needed for depolarization of the sensory hair cells in response to sound.…”

Section: Development Is Arrested In the Deaf Human Auditory Nerve Andmentioning

confidence: 99%

Use It or Lose It? Lessons Learned from the Developing Brains of Children Who are Deaf and Use Cochlear Implants to Hear

et al. 2011

View full text Add to dashboard Cite

In the present paper, we review what is currently known about the effects of deafness on the developing human auditory system and ask: Without use, does the immature auditory system lose the ability to normally function and mature? Any change to the structure or function of the auditory pathways resulting from a lack of activity will have important implications for future use through an auditory prosthesis such as a cochlear implant. Data to date show that deafness in children arrests and disrupts normal auditory development. Multiple changes to the auditory pathways occur during the period of deafness with the extent and type of change being dependent upon the age and stage of auditory development at onset of deafness, the cause or type of deafness, and the length of time the immature auditory pathways are left without significant input. Structural changes to the auditory nerve, brainstem, and cortex have been described in animal models of deafness as well in humans who are deaf. Functional changes in deaf auditory pathways have been evaluated by using a cochlear implant to stimulate the auditory nerve with electrical pulses. Studies of electrically evoked activity in the immature deaf auditory system have demonstrated that auditory brainstem development is arrested and that thalamo-cortical areas are vulnerable to being taken over by other competitive inputs (cross-modal plasticity). Indeed, enhanced peripheral sight and detection of visual movement in congenitally deaf cats and adults have been linked to activity in specific areas of what would normally be auditory cortex. Cochlear implants can stimulate developmental plasticity in the auditory brainstem even after many years of deafness in childhood but changes in the auditory cortex are limited, at least in part, by the degree of reorganization which occurred during the period of deafness. Consequently, we must identify hearing loss rapidly (i.e., at birth for congenital deficits) and provide cochlear implants to appropriate candidates as soon as possible. Doing so has facilitated auditory development in the thalamo-cortex and allowed children who are deaf to perceive and use spoken language.

show abstract

Multiple effects of childhood deafness on cortical activity in children receiving bilateral cochlear implants simultaneously

Cited by 26 publications

References 34 publications

Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

Electrically Evoked Auditory Event-Related Responses in Patients with Auditory Brainstem Implants: Morphological Characteristics, Test–Retest Reliability, Effects of Stimulation Level, and Association with Auditory Detection

Rapid bilateral improvement in auditory cortex activity in postlingually deafened adults following cochlear implantation

Use It or Lose It? Lessons Learned from the Developing Brains of Children Who are Deaf and Use Cochlear Implants to Hear

Contact Info

Product

Resources

About