Multiple eccrine spiradenomas in a linear or zosteriform distribution involving the right side of the body

Zhai, Zhifang; Yang, Xichuan; Fei, Hao; Ye, Qingyi; Zhong, Baiyu

doi:10.1111/j.1365-4632.2008.03761.x

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…Clinically, these neoplasms appear as subcutaneous well-delineated painful masses that can grow to several centimeters in size, most commonly seen on the head and neck region; however, they have been reported in many different anatomic sites 1,16 . They can present as multiple lesions and, in some cases, they can be linear, zosteriform, and blaschkoid 11,17–20 . Spiradenomas can develop concomitantly with cylindromas, trichoepitheliomas, and trichoblastomas and be associated in patients with Brooke-Spiegler syndrome 21 .…”

Section: Discussionmentioning

confidence: 99%

Spiradenoma With Adenoid Cystic Carcinoma–like Changes

Plaza,

Kastnerova,

Gru

et al. 2023

American Journal of Surgical Pathology

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Spiradenomas are benign cutaneous adnexal neoplasms with sweat gland differentiation that can manifest a broad spectrum of histomorphologic appearances. While they show a characteristic histopathologic phenotype and clinical management involves surgical excision with a low risk of recurrence, there have been unusual histopathologic variants of spiradenoma reported, including cases with adenoid cystic carcinoma (ACC)-like changes. Primary cutaneous ACC is a low-grade malignancy presenting as a subcutaneous mass with the potential for local invasion, perineural invasion, and high rates of local recurrence after excision. The diagnosis of spiradenomas with ACC-like features can be challenging, especially when only the ACC-like component is present for evaluation. A retrospective analysis of 21 cases of spiradenoma with ACC-like changes were obtained from large academic institutions, was performed, and summarized below. All cases showed background of conventional spiradenoma, and the ACC-like areas represented a component in all lesions. The percentage of ACC-like component ranged from 5% to 40% in all cases. The ACC-like component was multifocal and without pleomorphism, perineural and/or vascular invasion, necrosis, or increased mitotic activity. MYB translocation and protein expression was studied in 16 cases by fluorescence in situ hybridization, polymerase chain reaction, and immunohistochemistry. All studied cases were negative for MYB/NFIB, MYBL1, and MYBF by fluorescence in situ hybridization and polymerase chain reaction and 3 cases were positive for MYB expression by immunohistochemistry. Our study expands on spiradenomas with ACC-like features that ought to be considered in the differential diagnosis of cutaneous neoplasms such as primary cutaneous ACC. Our results indicate that a thorough histopathologic inspection and strict application of well-defined histologic criteria are necessary to support the diagnosis of this unusual histopathologic variant. These tumors can be difficult to diagnose, and awareness of their histomorphologic spectrum will facilitate definitive diagnosis and avoid misdiagnosis with other conditions.

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Section: Discussionmentioning

confidence: 99%

Spiradenoma With Adenoid Cystic Carcinoma–like Changes

Plaza,

Kastnerova,

Gru

et al. 2023

American Journal of Surgical Pathology

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“…Many cutaneous diseases are known to follow a dermatomal distribution; herpes zoster and herpes simplex are the most commonly recognized infectious diseases. Nodular eruptions with a segmental pattern may occur in cutaneous diseases, such as neurofibromatosis, spiradenomas, 1 leiomyomas, trichoepitheliomas, and vascular hamartomas 2 . Infectious granuloma diseases, such as syphilis and cutaneous leishmaniasis, may also follow a dermatomal pattern 3 …”

Section: Discussionmentioning

confidence: 99%

Leprosy presenting as nodular eruptions in a segmental distribution

Chern

Yau

2009

Int J Dermatology

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“…Los EE múltiples se manifiestan como nódulos agrupados, dolorosos, de 2 a 3 cm de diámetro, que suelen ubicarse en el polo cefálico, el tronco o las extremidades y pueden disponerse en tres patrones diferentes: lineal, nevoide y zosteriforme 7,8 . Esta última variante coincide con el caso de la paciente y el publicado por Agnihotri et ál., aunque difiere en el tamaño y la localización 2 .…”

Section: Comentariosunclassified

“…Cada nódulo muestra en su interior un patrón trabecular, constituido por dos tipos celulares: células epiteliales grandes con un núcleo pálido en el centro y células basófilas y pequeñas en la periferia. Además, suelen observarse pequeños linfocitos dispersos en las zonas trabeculares 6,7 .…”

Section: Comentariosunclassified