Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

Que, Jianwene; Okubo, Tadashi; Goldenring, James R.; Nam, Ki Taek; Kurotani, Reiko; Morrisey, Edward E.; Taranova, Olena; Pevny, Larysa; Hogan, Brigid L.M.

doi:10.1242/dev.003855

Cited by 484 publications

(588 citation statements)

References 48 publications

(61 reference statements)

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“…Indeed, mutants showed severe defects of stomach, lung, and eye development, confirming the role of Sox2 in the development of foregut endoderm and retina [33][34][35][36]. Sox2 loxP/lacZ ;Blimp1 Cre mutant eyes showed a strong reduction of the lens vesicle at 12.5 dpc, while at later stages (17.5 dpc), also the retina was severely impaired (Supporting Information Fig.…”

Section: Sox2 Is Required For the Development Of Eye And Foregut Endomentioning

confidence: 55%

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

et al. 2013

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Sox2 is a pluripotency-conferring gene expressed in primordial germ cells (PGCs) and postnatal oocytes, but the role it plays during germ cell development and early embryogenesis is unknown. Since Sox2 ablation causes early embryonic lethality shortly after blastocyst implantation, we generated mice bearing Sox2-conditional deletion in germ cells at different stages of their development through the Cre/loxP recombination system. Embryos lacking Sox2 in PGCs show a dramatic decrease of germ cell numbers at the time of their specification. At later stages, we found that Sox2 is strictly required for PGC proliferation. On the contrary, Sox2 deletion in meiotic oocytes does not impair postnatal oogenesis and early embryogenesis, indicating that it is not essential for oocyte maturation or for zygotic development. We also show that Sox2 regulates Kit expression in PGCs and binds to discrete transcriptional regulatory sequences of this gene, which is known to be important for PGCs survival and proliferation. Sox2 also stimulates the expression of Zfp148, which is required for normal development of fetal germ cells, and Rif1, a potential regulator of PGC pluripotency.

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Section: Sox2 Is Required For the Development Of Eye And Foregut Endomentioning

confidence: 55%

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

et al. 2013

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“…In the developing lung, Sox2 is normally expressed in endoderm progenitors of the proximal airways and is absent in the distal endoderm (Fig. 3A) (Que et al, 2007). Conversely, Sox9 is expressed at the highest levels in the distal lung endoderm progenitors and expression in distal progenitors decreases significantly so that by E16.5, Sox9 is detected in only a small subset of cells in the terminal distal endoderm (Fig.…”

Section: Research Articlementioning

confidence: 95%

Regulation of lung endoderm progenitor cell behavior by miR302/367

et al. 2011

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SUMMARYThe temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels. We show that the miR302/367 cluster is a target of the transcription factor Gata6 in mouse lung endoderm and regulates multiple aspects of early lung endoderm progenitor development. miR302/367 is expressed at early stages of lung development, but its levels decline rapidly as development proceeds. Gain-and loss-of-function studies show that altering miR302/367 expression disrupts the balance of lung endoderm progenitor proliferation and differentiation, as well as apical-basal polarity. Increased miR302/367 expression results in the formation of an undifferentiated multi-layered lung endoderm, whereas loss of miR302/367 activity results in decreased proliferation and enhanced lung endoderm differentiation. miR302/367 coordinates the balance between proliferation and differentiation, in part, through direct regulation of Rbl2 and Cdkn1a, whereas apical-basal polarity is controlled by regulation of Tiam1 and Lis1. Thus, miR302/367 directs lung endoderm development by coordinating multiple aspects of progenitor cell behavior, including proliferation, differentiation and apical-basal polarity.

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“…mesodermal derivatives, but how these interact with endoderm-autonomous regional cuing needs much more detailed study. There are several notable endodermal region-or organ-specific transcription factors (TFs) that are differentially expressed along the A-P axis, which include Six1 and Six4 (pharyngeal endoderm) (Zou et al, 2006), Sox2 (stomach) (Que et al, 2007), Nkx2.1 (lung) (Minoo et al, 1999), Hhex (liver) (MartinezBarbera et al, 2000;Keng et al, 2000), Pdx1 (pancreas, duodenum, posterior stomach, common bile duct) (Offield et al, 1996), and the caudal homeobox genes Cdx1 and Cdx2 (intestine) (Beck et al, 1995(Beck et al, , 2003.…”

Section: Figmentioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

525

594

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Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature b-cells. Developmental Dynamics 240:530-565,

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Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

Cited by 484 publications

References 48 publications

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

Regulation of lung endoderm progenitor cell behavior by miR302/367

Pancreas organogenesis: From bud to plexus to gland

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