Multiple dermatomyofibromas

Abstract

This study describes a case of a 19-year-old patient with seven asymptomatic lesions on the chest, measuring between 0.5 to 1cm in diameter, with no history of trauma in the region. The immunohistochemical evaluation was positive for vimentin and smooth muscle actin, determining Dermatomyofibroma as definitive diagnosis. Dermatomyofibroma is a benign skin tumor, with a myofibroblastic origin, prevalent in young women. It usually presents as a single lesion, with very few reports of multiple lesions.

Multiple pediatric dermatomyofibromas in a patient with a history of embryonal rhabdomyosarcoma

“… 3 , 4 , 5 , 6 Interestingly, with the addition of our case, 80% of the reported cases of multiple DMFs occurred in pediatric patients, suggesting that this phenotype may be more common in this population. 3 , 4 , 5 Furthermore, similarly to our case, one of the few other reported cases of multiple pediatric DMFs presented in a child with a history of embryonal “small-round-cell” solid tumor, raising the possibility of an association between multiple DMFs and embryonal tumors. 3 The reason for this possible association remains unclear but may be related to upregulation of growth factors, fibrogenic cytokines, and signaling pathways, leading to myofibroblast proliferation.…”

Cutaneous desmoid‐type fibromatosis: A rare case with molecular profiling

“…In dermatomyofibroma, the spindle cells typically grow in fascicles that are distinctly parallel to the epidermis. Furthermore, the cells of dermatomyofibroma have not been reported to express nuclear beta‐catenin, although only a small number of published cases have reported this marker 5‐7 . While the lesion shows some histopathologic resemblance to a hyperplastic scar, the lack of a history of preceding trauma and absence of vertically oriented capillary‐type vessels on original biopsy argue against this possibility.…”

“…Furthermore, the cells of dermatomyofibroma have not been reported to express nuclear beta-catenin, although only a small number of published cases have reported this marker. [5][6][7] While the lesion shows some histopathologic resemblance to a hyperplastic scar, the lack of a history of preceding trauma and absence of vertically oriented capillary-type vessels on original biopsy argue against this possibility. Interestingly, nuclear positivity of beta catenin has been reported in the context of scars, although an underlying pathogenic CTTNB1 mutation would not be expected.…”

Linear dermatomyofibroma over the nape of neck: a report of an unusual case and literature review

“…The upper arm, posterior aspect of the neck and axillary region are other possible but less frequent sites. The lesion is usually solitary, but there were two reported cases of multiple dermatomyofibromas in the literature [4,5]. The lesion is characterized by the presence of an ill-defined indurated plaque showing a variable and slightly erythematous discoloration.…”

“…[3] reported a considerable number of cases that were managed by marginal and incomplete excision, in spite of that, none of these cases recurred or showed evidence of progression. Hence, the prognosis of dermatomyofibroma is excellent [5,7].…”