Multiple cranial neuropathies in cerebral venous sinus thrombosis

Shariff, Erum; Alhameed, Majed

doi:10.1093/omcr/omu007

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…She was discharged after a 40-day hospitalization with only slight right abducens nerve paralysis. Mubbashir Shariff et al (Mubbashir Shariff and Alhameed, 2014 ) reported a 19-year-old boy with extensive CVT after whiplash injuries. The CVT manifested as right facial nerves paralysis and ipsilateral venous sinus thrombosis.…”

Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Luo

Tian

Wang

2018

Front. Aging Neurosci.

123

145

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Cerebral venous thrombosis (CVT), also called cerebral venous sinus thrombosis (CVST), is a cerebrovascular disease with diverse clinical manifestations that often affects young adults, women of childbearing age, and children. It's most common clinical manifestations are headache, seizures, altered consciousness, and neurological focal signs on physical examination. CVT can manifest as a single symptom, or it can present as a syndrome consisting of multiple symptoms. This non-specific clinical picture makes diagnosing CVT difficult. Although the mortality rate of CVT has been significantly reduced by improvements in treatment and diagnostic techniques, the mortality rate of severe CVT remains as high as 34.2%. Survivors of this type of CVT have varying degrees of residual symptoms and are not able to return to their previous work. Hence, we performed a comprehensive literature search in the PubMed, EMBASE, and Medline databases to review the diagnosis and treatment of CVT.

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Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Luo

Tian

Wang

2018

Front. Aging Neurosci.

123

145

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“…Cerebral venous sinus thrombosis (CVST) is a stroke caused by blockage of cortical veins and dural venous sinuses which leads to infarction of the draining zone brain parenchyma. It manifests as headache (in 75–95% of cases), seizures, papilledema, altered consciousness, and focal neurological deficits (1–4). CVST is the least common form of acute cerebrovascular disease, accounting for just 0.5% of all types of stroke (5–7).…”

Section: Introductionmentioning

confidence: 99%

Role of Decompressive Craniectomy in the Management of Cerebral Venous Sinus Thrombosis

Avanali¹,

Gopalakrishnan

Devi

et al. 2019

Front. Neurol.

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Cerebral venous sinus thrombosis (CVST) is a relatively uncommon cause of stroke more often affecting women and younger individuals. Blockage of the venous outflow rapidly causes edema and space-occupying venous infarctions and it seems intuitive that decompressive craniectomy (DC) can effectively reduce intracranial pressure just like it works for malignant middle cerebral artery infarcts and traumatic brain injury. But because of the relative rarity of this type of stroke, strong evidence from randomized controlled trials that DC is a life-saving procedure is not available unlike in the latter two conditions. There is a possibility that other forms of interventions like endovascular recanalization, thrombectomy, thrombolysis, and anticoagulation, which cannot be used in established middle cerebral artery infarcts and TBI, can reverse the ongoing pathology of increasing edema in CVST. Such interventions, although presently unproven, could theoretically obviate the need for DC when used in early stages. However, in the absence of such evidence, we recommend that DC be considered early as a life-saving measure whenever there are large hemorrhagic infarcts, expanding edema, radiological, and clinical features of impending herniation. This review gives an overview of the etiology and risk factors of CVST in different patient populations and examines the effectiveness of DC and other forms of interventions.

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“…The partial cranial nerve 3 palsy accompanying the bilateral 6th nerve palsies may also be explained by CVST. It has been reported in multiple cases of CVST 11 and is most likely due to a vascular pressure gradient that leads to edema and dysfunction of multiple cranial nerves.…”

Section: Discussionmentioning

confidence: 99%

Vision Loss Secondary to COVID-19 Associated Bilateral Cerebral Venous Sinus Thromboses

Omari

Kally

Schimmel

et al. 2022

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A young, morbidly obese woman with recent SARS-CoV-2 infection requiring hospitalization presented with visual and neurologic complications secondary to bilateral cerebral venous sinus thromboses. With elevated intracranial pressure and severe papilledema, she rapidly progressed to complete bilateral vision loss despite anticoagulation, therapeutic lumbar punctures with lumbar drain, bilateral optic nerve sheath fenestrations, and endovascular thrombectomy. It is possible that obese patients with a SARS-CoV-2 infection may be at greater risk of hypercoagulable cerebrovascular complications. It is impossible to know if an even more rapid response would have led to a different outcome, but we report this case in the hope that publishing this and similar cases may result in improved treatment protocols to preserve vision.

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Multiple cranial neuropathies in cerebral venous sinus thrombosis

Cited by 9 publications

References 11 publications

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review

Role of Decompressive Craniectomy in the Management of Cerebral Venous Sinus Thrombosis

Vision Loss Secondary to COVID-19 Associated Bilateral Cerebral Venous Sinus Thromboses

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