Multiple congenital hemangiopericytomas of the head and neck

Seibert, Joanna J.; Seibert, Robert W.; Weisenburger, Dennis S.; Allsbrook, William C.

doi:10.1288/00005537-197806000-00012

Cited by 36 publications

(12 citation statements)

References 11 publications

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“…Data regarding site distribution were available for 169 patients [7,10,11,26,27,29]. Figure i displays the whole body distribution of HPC for head and neck (21%), lower extremity (32%), trunk and pelvis (37%), and upper extremity (9%).…”

Section: Site Distribution Of Hpcmentioning

confidence: 99%

Meningeal hemangiopericytoma: defining the role for radiation therapy

Bastin

Mehta

1992

J Neuro-Oncol

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Meningeal hemangiopericytoma is a rare neoplasm arising from perivascular pericytes. Accounting for < 1% of all brain tumors, these neoplasms are characterized by a high local recurrence rate and metastatic potential. Meningeal hemangiopericytoma occur most frequently during the fifth decade of life, with an almost equal sex incidence. To evaluate and define the role for primary, postoperative, or palliative radiotherapy in meningeal hemangiopericytoma, data were gathered from our own tumor registry and compiled with an extensive analysis of published series and case reports. This analysis reveals a 90%, 9 year actuarial risk for local recurrence following surgical resection only. Interestingly, less than 33% of these recurrences were noted within the first five years, which may account for the false assumption that these tumors are highly curable with surgical resection only. Radiation therapy appears to reduce this local recurrence rate, prolonging disease-free and overall survival. Radiation responses are dose dependent, with > 50 Gray providing superior long-term disease-free survival. Meningeal hemangiopericytoma are characterized by a slow, but progressive radiographic response to ionizing radiation, not unlike other radiated, highly vascular brain lesions, such as arteriovenous malformations. A retrospective review of clinical demographics, sites of meningeal origin, radiographic and pathologic findings and the role of chemotherapy is also presented.

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Section: Site Distribution Of Hpcmentioning

confidence: 99%

Meningeal hemangiopericytoma: defining the role for radiation therapy

Bastin

Mehta

1992

J Neuro-Oncol

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“…Jha et al [21] reported success with radiotherapy when there was gross or microscopic evidence of tumour remaining after excision, and adjuvant radiotherapy was used with success by Borg and Benjamin [22]. Other authors have reported that radiotherapy is ineffective [14,15,23]. Metastatic disease has only been reported in three cases of congenital hemangiopericytoma [4,15,24] although the adult form of the tumour has a rate of distant metastasis of up to 56%, mainly to the lung and skeleton [8,25].…”

Section: Discussionmentioning

confidence: 99%

Infantile Hemangiopericytoma: Two Cases Report and Literature Review

Al-Saied¹,

Abokifa²,

Al-Saeed³

et al. 2011

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Hemangiopericytoma is a rare vascular tumour of infants. Although generally considered to be benign, local recurrence and metastases can occur. Herein, we report on two full term girls, delivered with lumbosacral swelling and left thigh swelling respectively. Complete surgical excision with safety margins was performed for each lesion. Histologic examination of both lesions showed picture of infantile hemangiopericytoma. There is no evidence of local recurrence or distant metastasis during last 20 and 17 months for 1 st case and 2 nd case respectively. In conclusion; most infantile hemangiopericytoma follow a benign course. Rarely these tumours behave aggressively with local infiltration, recurrences and even distant metastases. Careful follow up is therefore essential.

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“…20 Other authors have reported that radiotherapy is ineffective. 12,13,21 There is considerable concern regarding its use in the limbs of young children. We decided not to use adjuvant therapy in this patient since the value of such treatment at the time of diagnosis had not been established.…”

Section: Discussionmentioning

confidence: 99%

Recurrent congenital haemangiopericytoma in a child

O’Donnell

Devitt

Kutty

et al. 2001

The Journal of Bone and Joint Surgery. British volume

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A five-day-old boy was referred with a soft-tissue mass in his right upper arm. Plain radiographs and ultrasound demonstrated a lesion extending from the axilla to the elbow on the posterolateral aspect of the humerus. Open biopsy confirmed the diagnosis of congenital haemangiopericytoma. After MRI and selective angiography, excision biopsy was carried out, but no adjuvant therapy was administered. At further examination, four years and ten months later, he was noted to have three small nodules at the site of the original tumour. Excision biopsy confirmed this to be a local recurrence, although the lesion was less cellular with no appreciable mitotic activity. Congenital haemangiopericytoma is a rare cause of a soft-tissue mass in children. Most tumours are benign, and recurrence is uncommon. The treatment is controversial, but most centres recommend the use of adjuvant chemotherapy, combined with complete excision. We recommend treatment with doxorubicin. Orthopaedic surgeons should be familiar with this tumour since 30% to 50% of cases occur in the limbs.

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Multiple congenital hemangiopericytomas of the head and neck

Cited by 36 publications

References 11 publications

Meningeal hemangiopericytoma: defining the role for radiation therapy

Meningeal hemangiopericytoma: defining the role for radiation therapy

Infantile Hemangiopericytoma: Two Cases Report and Literature Review

Recurrent congenital haemangiopericytoma in a child

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