Multiple Comparisons Among Means

Dunn, Olive Jean

doi:10.2307/2282330

Cited by 1,368 publications

(1,288 citation statements)

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“…Group differences in the parameters of the optimal model were tested with the bootstrapping method as described above. The Bonferroni procedure was used to correct for multiple comparisons (Dunn, 1961). …”

Section: Methodsmentioning

confidence: 99%

Autonomic and brain responses associated with empathy deficits in autism spectrum disorder

Eilam‐Stock

Zhou

et al. 2015

Human Brain Mapping

110

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Accumulating evidence suggests that autonomic signals and their cortical representations are closely linked to emotional processes, and that related abnormalities could lead to social deficits. Although socio-emotional impairments are a defining feature of autism spectrum disorder (ASD), empirical evidence directly supporting the link between autonomic, cortical, and socio-emotional abnormalities in ASD is still lacking. In this study, we examined autonomic arousal indexed by skin conductance responses (SCR), concurrent cortical responses measured by functional magnetic resonance imaging, and effective brain connectivity estimated by dynamic causal modeling, in seventeen un-medicated high-functioning adults with ASD and seventeen matched controls, while they performed an empathy-for-pain task. Compared to controls, adults with ASD showed enhanced SCR related to empathetic pain, along with increased neural activity in the anterior insular cortex, although their behavioral empathetic pain discriminability was reduced and overall SCR was decreased. ASD individuals also showed enhanced correlation between SCR and neural activities in the anterior insula. Importantly, significant group differences in effective brain connectivity were limited to greater reduction in the negative intrinsic connectivity of the anterior insular cortex in the ASD group, indicating a failure in attenuating anterior insular responses to empathetic pain. These results suggest that aberrant interoceptive precision, as indexed by abnormalities in autonomic activity and its central representations, may underlie empathy deficits in ASD.

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Section: Methodsmentioning

confidence: 99%

Autonomic and brain responses associated with empathy deficits in autism spectrum disorder

Eilam‐Stock

Zhou

et al. 2015

Human Brain Mapping

110

View full text Add to dashboard Cite

show abstract

“…Unless specified otherwise, all reported p values were based on two-tailed criteria and corrected for multiple comparisons using the Bonferroni method (i.e. p corr = p uncorr × number of comparisons made) (Dunn, 1961).…”

Section: Statistical Analysesmentioning

confidence: 99%

Susceptibility to Optical Illusions Varies as a Function of the Autism-Spectrum Quotient but not in Ways Predicted by Local–Global Biases

Chouinard

Unwin

Landry

et al. 2016

J Autism Dev Disord

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“…Since some statisticians advocate that all multiple comparison data tests should be corrected for the number of comparisons made, we have also calculated Dunn's correction 26 for the data shown in tables 1 and 2. The Dunn correction reduces the significance of differences established by conventional t testing.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen catabolism in patients with type II and type IV hyperlipidemia. Effect of dietary and clofibrate treatment on laboratory findings.

Fletcher¹,

Alkjærsig²,

Schonfeld³

et al. 1981

Arteriosclerosis

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Fibrinogen catabolism was studied by plasma fibrinogen chromatography and other methods in 99 subjects with hyperlipoproteinemla Types lla, Mb, and IV, and in 24 control subjects with normal blood llpid values. Subjects with either a history of thromboembolic vascular disease or clinical evidence of atherosclerosis were excluded. Type II subjects (I.e., the combined group of Type lla and lib subjects) showed an elevation of plasma high molecular weight fibrinogen complexes, which Is indicative of enhanced fibrin formation. They also showed an elevation of fibrinogenflrst-derivatlve, which Is Indicative of fibrinogenolysls and Increased plasma euglobulin activity. Subjects with Type IV hyperlipoproteinemla showed similar findings to those of Type II except that high molecular weight fibrinogen complex concentration was normal. Subsequently, 36 patients received a fat-controlled, low cholesterol diet and were studied In a blind, random, crossover study of dietary vs clofibrate treatment. T he role of local fibrin deposition in atherosclerosis in humans remains uncertain. Histological evidence supports the view that local fibrin and platelet deposition is an integral pathological feature of progressive atherosclerosis. 1 "* Elevation of plasma fibrinogen has also been shown to be as significantly associated with the development of ischemic heart disease as elevation of cholesterol. 7 Yet studies to demonstrate enhanced fibrin formation in patients with atherosclerosis have seldom been attempted. 8 patients with hyperlipidemia Types II and IV (namely, patients at risk of developing age-accelerated atherosclerosis), is unknown. Although studies with isotopically labeled fibrinogen have failed to show a shortened half-life survival time in the atherosclerotic subject, 9 fibrin formation under physiological conditions accounts for only 2% to 3% of overall fibrinogen catabolism. 10 Consequently, fibrinogen Ti* is an insensitive measure of fibrin formation and deposition, and failure to demonstrate alteration in fibrinogen Tŝ urvival does not exclude substantial change in fibrin formation rates.Plasma fibrinogen chromatography has provided a new approach to the study of fibrinogen catabolism. 11 " 13 This procedure quantifies in plasma the percentage and concentration of high molecular weight fibrinogen complexes (HMWFC), native fibrinogen, and derivatives of fibrinogen smaller than the native molecule, collectively termed "fibrinogen-first-derivative" and mostly composed of fibrinogen fragments X and Y.

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Multiple Comparisons Among Means

Cited by 1,368 publications

References 0 publications

Autonomic and brain responses associated with empathy deficits in autism spectrum disorder

Autonomic and brain responses associated with empathy deficits in autism spectrum disorder

Susceptibility to Optical Illusions Varies as a Function of the Autism-Spectrum Quotient but not in Ways Predicted by Local–Global Biases

Fibrinogen catabolism in patients with type II and type IV hyperlipidemia. Effect of dietary and clofibrate treatment on laboratory findings.

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