Multiple chemical sensitivities: A systematic review of provocation studies

Das‐Munshi, Jayati; Rubin, G. James; Wessely, Simon

doi:10.1016/j.jaci.2006.07.046

Cited by 97 publications

(85 citation statements)

References 40 publications

(58 reference statements)

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“…Self-reported sensitivities are often attributed to diverse environmental stressors such as noise, odors, chemical substances and EMF [21][22][23]. Similar to MHW, such subjective environmental sensitivities are associated with more NSPS, poorer perceived health and increased illness behavior particularly related to alternative therapies compared to the broader population [24].…”

Section: Introductionmentioning

confidence: 99%

“…Similar to MHW, such subjective environmental sensitivities are associated with more NSPS, poorer perceived health and increased illness behavior particularly related to alternative therapies compared to the broader population [24]. In contrast to sufferers' experiences, the attributed causes are often not supported by scientific evidence [7,23], while the reported health complaints are not fully explained by medical or psychiatric morbidity [24].…”

Section: Introductionmentioning

confidence: 99%

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The relationship of modern health worries to non-specific physical symptoms and perceived environmental sensitivity: A study combining self-reported and general practice data

Baliatsas

Kamp

Hooiveld

et al. 2015

Journal of Psychosomatic Research

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a b s t r a c t a r t i c l e i n f oObjective: The present study investigates the association of modern health worries (MHW) with self-reported as well as general practitioner (GP)-registered non-specific physical symptoms (NSPS), medication use, alternative therapy consultations, sleep quality and quality of life. The interrelation between MHW, general environmental sensitivity and the aforementioned outcomes is also explored. Methods: Self-reported questionnaires and data from electronic medical records from 21 general practices in The Netherlands were combined in a sample of 5933 adult participants. Results: The majority of the participants reported increased worries about potential health effects from environmental exposures. The highest worry scores were reported by people who perceived themselves as more vulnerable to environmental stressors. After adjustment for socio-demographic characteristics and diagnosed psychiatric morbidity, higher MHW were significantly associated with increased self-reported prevalence and duration of NSPS, symptom-related healthcare utilization, GP-registered NSPS, alternative therapy consultations and lower sleep quality and quality of life. These associations were statistically mediated by perceived environmental sensitivity. No association was observed between worries and GP-registered medication prescriptions. Conclusion: Modern health worries are very common in the general population. They are associated with self-reported as well as clinically defined NSPS and as such might play a key role in the process of developing and maintaining environmental sensitivities and related symptoms. A large cross-cultural longitudinal study would help to determine important aspects such as temporal precedence and stability of MHW and the relevant psychosocial context within which symptomatic conditions occur.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship of modern health worries to non-specific physical symptoms and perceived environmental sensitivity: A study combining self-reported and general practice data

Baliatsas

Kamp

Hooiveld

et al. 2015

Journal of Psychosomatic Research

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“…However, there are no clinically unique signs, laboratory tests, tissue pathology, or illness diagnostics that have been identified as unique to MCS. It is also unclear whether symptoms are physiologically or psychologically generated [67,68]. The World Health Organization's database on classification of disease and related health issues does not recognize MCS or environmental sensitivity as a valid diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Cumulative Effects Analysis of the Water Quality Risk of Herbicides Used for Site Preparation in the Central North Island, New Zealand

Neary

Baillie

2016

Water

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Herbicide use varies both spatially and temporally within managed forests. While information exists on the effects of herbicide use on water quality at the site and small catchment scale, little is known about the cumulative effects of herbicide use at the landscape scale. A cumulative effects analysis was conducted in the upper Rangitaiki catchment (118,345 ha) in New Zealand, to determine the risk to water quality from two herbicides commonly used for post-plant weed control: terbuthylazine and hexazinone. Data from a 12.5 ha catchment study within the Rangitaiki Basin, where these herbicides were aerially applied in two consecutive years, were used to model herbicide concentrations entering the Rangitaiki River for the remaining treated areas in the catchment for the same two spray seasons. A spreadsheet model routed herbicide residues from their point of entry into the river to a flow gauge on the Rangitaiki River. Modeling of chemical residue loadings and concentrations of terbuthylazine and hexazinone indicated that potential herbicide residues in stream waters would be mainly below analytical detection limits and pose no risk to the aquatic environment or human health and safety. Safety factors for drinking water quality standards, aquatic organisms, and human Acceptable Daily Intake levels were very large.

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“…Also the pathogenetic mechanisms remain largely unknown (10): recent studies indicate contact with airborne chemicals (11) as the cause of symptoms that would induce mechanisms of sensitivity of the central nervous system which would follow classic symptoms of psychological conditioning (12,13). The association of this pathological condition with psychiatric disorders (14), such as depression and anxiety, suggests the hypothesis that MCS belongs to the spectrum of somatoform disorders (15).…”

Section: Discussionmentioning

confidence: 99%

Anaesthesia Management in Patients with Multiple Chemical Sensitivity Syndrome

Piroli

Ciccozzi

Petrucci

et al. 2013

Int J Immunopathol Pharmacol

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Multiple Chemical Sensitivity (MCS) is characterised by the appearance of numerous and sometimes severe symptoms, when subjects are in contact with various chemicals and medicinal substances. Currently there are no useful guidelines for managing clinical issues and, specifically, anaesthesia for patients with MCS. This case report describes anaesthesia management in a patient affected by clinically documented MCS and a latex allergy, a candidate for a laparoscopic cholecystectomy operation.

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Multiple chemical sensitivities: A systematic review of provocation studies

Cited by 97 publications

References 40 publications

The relationship of modern health worries to non-specific physical symptoms and perceived environmental sensitivity: A study combining self-reported and general practice data

The relationship of modern health worries to non-specific physical symptoms and perceived environmental sensitivity: A study combining self-reported and general practice data

Cumulative Effects Analysis of the Water Quality Risk of Herbicides Used for Site Preparation in the Central North Island, New Zealand

Anaesthesia Management in Patients with Multiple Chemical Sensitivity Syndrome

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