Multiple cervical ganglioneuroma: A case report and review of the literature

Ma, Junli; Liu, Limin; Liu, Hongchen

doi:10.3892/ol.2012.767

Cited by 28 publications

(22 citation statements)

References 22 publications

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“…There have been rare case reports of malignancy from ganglioneuromas, however it is believed that these tumours are actually metastases of neuroblastomas or ganglioneuroblastomas that have subsequently matured into ganglioneuromas. They are only found in the cervical neck region in 8% of cases 2…”

Section: Discussionmentioning

confidence: 99%

Postoperative Horner’s syndrome following excision of incidental cervical ganglioneuroma during hemithyroidectomy and parathyroid gland exploration

McCrory¹,

Kelly

Korda

2020

BMJ Case Rep

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This 49-year-old woman was referred to ear, nose and throat (ENT) with primary hyperparathyroidism. Imaging studies failed to localise the adenoma so she required four-gland parathyroid exploration. She also required diagnostic left hemithyroidectomy as she had a U3 nodule with multiple insufficient fine needle aspirations (FNAs). Intraoperatively, the left thyroidectomy proceeded uneventfully. No convincing left inferior parathyroid gland was identified however palpation revealed a 1 cm mass just medial to carotid artery. This was excised as probable ectopic parathyroid gland. She was discharged two days later. Thirteen days postoperatively she attended Eye Casualty with a left-sided Horner’s syndrome. A CT angio of aortic arch was normal. She was reviewed at ENT outpatients. Histopathology report of the expected ectopic parathyroid gland returned as benign ganglioneuroma, likely arising from her left sympathetic chain. Horner’s syndrome is a common side effect from excision of ganglioneuromas, but an incredibly rare side effect from thyroid or parathyroid surgery.

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Section: Discussionmentioning

confidence: 99%

Postoperative Horner’s syndrome following excision of incidental cervical ganglioneuroma during hemithyroidectomy and parathyroid gland exploration

McCrory¹,

Kelly

Korda

2020

BMJ Case Rep

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“…Careful examination should be made considering possibility of neurofibromatosis and other neurogenic tumors. Multiple ganglioneuroma in cervical region was also been reported in the literature 4 . Intraosseous ganglioneuroma is exceedingly rarely seen.…”

Section: Discussionmentioning

confidence: 81%

“…Scintigraphically, MIBG uptake has been reported in up to 57% of ganglioneuromas in one study 6 . With these image characteristics it remains difficult to discriminate ganglioneuroma from other lesions in the cervical region, including salivary gland tumors (pleomorphic adenoma), other neurogenic tumors (neurolemmoma, neurofibroma and fibrosarcomas) and soft tissue lesions (fibrosarcomas, rhabdomyosarcomas and malignant lymphomas) 4 .…”

Section: Discussionmentioning

confidence: 99%

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Parapharyngeal giant ganglioneuroma with multifocal bone involvement in a pediatric female patient

Salimov¹,

Süslü²,

Kuşçu³

et al. 2016

Turk J Pediatr

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Ganglioneuroma is a rare benign tumor that originates from neural crest. Tumor tends to be slow growing, asymptomatic but can cause symptoms because of pressure to neighboring structures. In the head and neck region they are relatively rarely seen. We hereby present a rare case of multiple ganglioneuromas that were located in parapharyngeal space, iliac bone and other bones in a 13-year-old girl. Patient underwent surgery for the excision of a large mass, extending from parapharyngeal space to neck, with transparotid and transcervical combined approach. After operation, MIBG (iodine-123-meta-iodobenzylguanidine) scintigraphy was performed and involvement of parietooccipital bone, lumbal vertebra, right iliac wing medial cortex and left humerus were detected. No adjuvant therapy was given to the patient. There is no evidence of recurrence in the head and neck region in the following 12 months. In conclusion, complete surgical excision of the tumor, if possible, is the treatment of choice with high success rate. Close clinical and radiological follow-up for these tumors after surgery should be made.

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“…The neural crest consists of a band of longitudinal cells between the neural tube and epidermis, when the neural tube is completed (12). Subsequently, sections of the neural crest cells migrate to the ventral side, while certain cells remain in the neural tube (spinal cord), when the neural crest is formed at the back of neural tube (13,14). Therefore, the conus medullaris region is a possible anatomical location for the origin of ganglioneuroma (4,(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

Wang

Dai

2015

Oncology Letters

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Abstract. Ganglioneuromas are rare, benign, well-differentiated tumors of the conus medullaris. Approximately 20 cases of spinal cord ganglioneuroma, and only 1 case of mixed chemodectoma-ganglioneuroma of the conus medullaris have been previously reported. The present study presents the case of a 38-year-old man with a histopathological diagnosis of conus medullaris ganglioneuroma. The patient presented with hypoesthesia in the lower limbs, muscle atrophy of the right lower limb and dysuria. Magnetic resonance imaging analysis led to a diagnosis of ependymoma. Histopathological analysis of the excised mass revealed typical, well-differentiated ganglion cells, consistent with a ganglioneuroma. The mass was associated with a neighboring syringomyelia. At an 18 month follow-up the patient had recovered, although some remaining difficulty in walking and urinating remained. The aim of the present report was to raise awareness that when ganglioneuromas present in unusual locations, analogous radiological findings may mislead investigators to consider more common pathologies and thus result in misdiagnosis. The present case demonstrates the importance of considering the potential differential diagnoses for neural tissue neoplasms.

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Multiple cervical ganglioneuroma: A case report and review of the literature

Cited by 28 publications

References 22 publications

Postoperative Horner’s syndrome following excision of incidental cervical ganglioneuroma during hemithyroidectomy and parathyroid gland exploration

Postoperative Horner’s syndrome following excision of incidental cervical ganglioneuroma during hemithyroidectomy and parathyroid gland exploration

Parapharyngeal giant ganglioneuroma with multifocal bone involvement in a pediatric female patient

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

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