Multiple cerebral microbleeds associated with disseminated intravascular coagulation

Cerebral microbleeds in the poisoned patient: An observational magnetic resonance imaging study

“…3 Cerebral microbleeds have been also reported in septic shock patients with or without DIC and/or cardiac arrest. [14][15][16] Despite similar locations, microbleeds in these patients with microangiopathies were responsible for both white and grey matter damage, thalami and dentate nuclei impairment, contrasting with our poisoned patients. Histopathological data found microscopic infarctions in the splenium of the corpus callosum caused by thrombosis or embolism but not haemorrhages, highlighting the contribution of microangiopathy.…”

“…Cerebral microbleeds have been also reported in septic shock patients with or without DIC and/or cardiac arrest 14–16 . Despite similar locations, microbleeds in these patients with microangiopathies were responsible for both white and grey matter damage, thalami and dentate nuclei impairment, contrasting with our poisoned patients.…”

“…This cerebral hypoperfusion hypothesis is strengthened by the observation of microbleeds in post-cardiac arrest anoxic brain injury patients. 14 An experimental study provided evidence that cerebral hypoperfusion may lead to increased blood-brain barrier permeability resulting from pericyte alterations in the corpus callosum, which generate microbleeds. 19 In most cases, additional coagulation impairments facilitate microbleed generation independently from the underlying aetiology.…”

Diffuse cerebral microbleeds in a patient with HIV and disseminated intravascular coagulation

“…Hypoxemia and critical illnesses such as sepsis and disseminated intravascular coagulopathy (DIC) are possible causes of massive microbleeds in the brain parenchyma [1]. We report a patient with human immunodeficiency virus (HIV) showing extensive cerebral microbleeds.…”