Multiple cerebral aneurysms as manifestations of cardiac myxoma: Brain imaging, digital subtraction angiography, and echocardiography

Chiang, Kuo-Hsien; Cheng, Hua-Ming; Chang, Bee-Song; Chiu, Cheng-Hui; Yen, Pao-Sheng

doi:10.1016/j.tcmj.2011.01.002

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Resection of the cardiac myxoma is useful in eliminating early neurological symptoms but cannot completely abolish the risk of delayed cerebral aneurysm formation. Chemotherapy results were equivocal [ 13 ]. Radiation therapy in combination with chemotherapy has been reported as an effective way in degradation of myxoma metastasis, therefore it may be useful in preventing the myxomatous aneurysms [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Oncotic Cerebral Aneurysms in a Case of Left Atrial Myxoma, Role of Imaging in Diagnostics and Treatment

Gupta

Agrawal

2015

Pol J Radiol

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SummaryBackgroundMyxomatous cerebral (oncotic) aneurysms following atrial myxoma is a rare neurological complication.Case ReportWe report an 11-year- old boy with left atrial myxoma and multiple cerebral oncotic aneurysms. The characteristics of these aneurysms are indefinite and variable. The “Metastasize and Infiltrate” theory may be the key mechanism in the formation of these aneurysms.ConclusionsMagnetic resonance imaging (MRI), computed tomography (CT) and angiography are useful in the diagnostics while digital subtraction angiography (DSA) is the best option. There are no definite guidelines for therapy of these aneurysms. Resection of cardiac myxomas, chemotherapy, radiotherapy, coil embolization and surgical treatment could be helpful.

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Section: Discussionmentioning

confidence: 99%

Oncotic Cerebral Aneurysms in a Case of Left Atrial Myxoma, Role of Imaging in Diagnostics and Treatment

Gupta

Agrawal

2015

Pol J Radiol

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“…Surgical treatment can eliminate the early neurological symptoms caused by atrial myxoma, but it cannot ensure the nonoccurrence of delayed intracranial aneurysms. The results from chemotherapy have been equivocal (31), but evidence has shown that the combination of radiotherapy and chemotherapy is useful for the treatment of myxo ma metastasis, thereby reducing the likelihood of formation of myxomatous aneurysms (32)(33)(34). Other investigators have suggested that despite independent reports of microsurgical resection/endovascular intervention, chemotherapy, and radiotherapy for the treatment of cardiac myxomatous intracranial aneurysms, there is still a lack of clear guidelines (35).…”

Section: Discussionmentioning

confidence: 99%

Delayed multiple intracranial aneurysms caused by left atrial myxoma: a case report and literature review

Wang¹,

Wang²,

Hu³

et al. 2022

Transl Pediatr

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Intracranial aneurysm may appear even after the removal of the cardiac myxoma. However, the pathogenesis and treatment of such aneurysm lesions are not clear. The study aimed to explore the clinical and imaging manifestation, hypothetical pathogenesis, and therapy in one case of left atrial myxoma causing multiple intracranial aneurysms. A 14-year-old male displayed a 3-hour history of episodic loss of consciousness and right hemiplegia after a leapfrog-like movement. The myxoma was diagnosed by a combination of clinical examination, leading to the diagnosis of mitral dynamic obstruction with a Grade III mitral diastolic murmur and tumor plop; magnetic resonance imaging, revealing multiple ischemic sites in both semi-oval centers; and transthoracic echocardiography, demonstrating a mitral valve obstruction.The myxoma was removed surgically; however, computed tomography angiography showed multiple intracranial aneurysms in both middle cerebral arteries 18 months after resection of the atrial myxoma. After conservative treatment, the patient had no neurological dysfunction symptoms for 5 years after myxoma resection. His condition is relatively stable. In conclusion, resection of the atrial myxoma may eliminate the early neurological symptoms, but it cannot ensure the nonoccurrence of delayed intracranial aneurysms. The neoplastic process theory was favored for explaining the aneurysm development in this case. According to the specific conditions of the patient, a combination of open surgery, chemotherapy, radiotherapy, and coil embolization is recommended.

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“…Myxoma is associated with the broad clinical triad of cardiac presentation (60%), sequelae of cerebral or systemic embolization (30-40%), and constitutional symptoms (30%). 1 Transthoracic echocardiography is generally used initially, but transesophageal echocardiography is a superior method for diagnosing this condition. 2 The mainstay of treatment for myxoma is surgical resection, particularly when the risk of further tumor embolism or valve obstruction is very high.…”

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confidence: 99%

“…2 The mainstay of treatment for myxoma is surgical resection, particularly when the risk of further tumor embolism or valve obstruction is very high. 1 The tumor can behave aggressively and tends to recur despite being a benign tumor. 3 The mobility, but not the size of the mass, may influence embolic potential.…”

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confidence: 99%

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Cerebral Aneurysm in Association with Left Atrial Myxoma

Alrohimi

Putko

Dijk

et al. 2019

Can. J. Neurol. Sci.

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Multiple cerebral aneurysms as manifestations of cardiac myxoma: Brain imaging, digital subtraction angiography, and echocardiography

Cited by 7 publications

References 11 publications

Oncotic Cerebral Aneurysms in a Case of Left Atrial Myxoma, Role of Imaging in Diagnostics and Treatment

Oncotic Cerebral Aneurysms in a Case of Left Atrial Myxoma, Role of Imaging in Diagnostics and Treatment

Delayed multiple intracranial aneurysms caused by left atrial myxoma: a case report and literature review

Cerebral Aneurysm in Association with Left Atrial Myxoma

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