Multiple Cerebral Aneurysms and Cardiac Myxoma

Burton, Charles; Johnston, John D.

doi:10.1056/nejm197001012820109

Cited by 93 publications

(33 citation statements)

References 10 publications

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“…Current hypothesis, therefore, assumes that tumor materials from cardiac myxomas embolize into the vasa vasorum of peripheral arteries and proliferate into the vessel wall. This leads to a weakening of subintimal tissue, such as the internal elastic lamina, and thereafter aneurysm formation [24]. Aneurysm formation associated with atrial myxoma is therefore not caused by blood-flow dynamics but by myxomatous tumor embolization and invasion into the vessel wall.…”

Section: Discussionmentioning

confidence: 99%

The imaging features of neurologic complications of left atrial myxomas

Liao

Ramkalawan

Liu

et al. 2015

European Journal of Radiology

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Section: Discussionmentioning

confidence: 99%

The imaging features of neurologic complications of left atrial myxomas

Liao

Ramkalawan

Liu

et al. 2015

European Journal of Radiology

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“…Cardiac myxomas may also cause aneurysms [22, 23, 24, 25]as well as cardio-embolic stroke. The growth of the embolism has been described as causing space-occupying lesions [26].…”

Section: Discussionmentioning

confidence: 99%

Transient Ischaemic Attack: A Common Initial Manifestation of Cardiac Myxomas

Álvarez-Sabín¹,

Lozano²,

Sastre‐Garriga³

et al. 2001

Eur Neurol

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Background and Aims: Cardiac myxomas may present clinically with many different features. Since highly effective treatments exist, it is important that they are diagnosed quickly in order to avoid further complications. Our aim was to determine the influence of neurological presentation in diagnosis and prognosis of cardiac myxomas. Methods: We have reviewed the clinical charts of 28 patients diagnosed with cardiac myxomas seen at our centre in the last 20 years. Results: Mean age at diagnosis in patients with neurological events was 49.22 years and 60.84 years in those without neurological manifestations (p = 0.0325). Most frequent presentations were: cardiac manifestations (92.8%), general manifestations (71.4%) and embolic events (39.3%). Nine patients (32.1%) presented with cerebral embolism; 7 of whom presented with transient ischaemic attacks (TIA), which was the first manifestation in 6 of them; 3 of them later suffered complete cerebral infarction with sequelae. Echocardiography confirmed diagnosis in 26 out of 27 patients in which it was performed. None of the patients presented neurological symptoms after surgery. Conclusion: The most frequent initial neurological manifestation in our series was TIA. Nevertheless, none of the patients were diagnosed after the first neurological symptom. Although the contribution of cardiac myxomas to the total amount of TIA is low, since surgery is highly effective and of low risk, and patients with neurological manifestations are younger, it is vital to consider the possibility of cardiac myxoma after a TIA of unknown origin.

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“…These include previous cranial irradiation, progressive hemifacial atrophy, coarctation of the aorta, sickle cell disease, cardiac myxoma, arteriovenous malformations, fibromuscular dysplasia, tuberous sclerosis, Von-Hippel-Lindau disease, Diamond-Blackfan syndrome, Ehlers-Danlos syndrome and Marfan’s syndrome [13,14,15,16,17,18,19,20,21,22,23]. Multiple traumatic aneurysms are most uncommon and if unrecognized may present with fatal rupture [24,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…These aneurysms are frequently giant in size and have a higher incidence of subarachnoid hemorrhage (SAH) as compared to the adult population [9, 10]. Multiple intracranial aneurysms in children are rare and there are only a few anecdotal reports in the literature [13,14,15,16,17,18,19,20,21,22,23]. A child with multiple aneurysms is presented and the pathogenesis and treatment options in such a case are discussed in light of the current literature.…”

Section: Introductionmentioning

confidence: 99%

Multiple Intracranial Aneurysms in a Child with Congenital Cyanotic Heart Disease

2006

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A 10-year-old child with transposition of the great arteries had multiple intracranial aneurysms. The child presented with pyogenic meningitis, and the investigations incidentally revealed numerous aneurysms involving both anterior and posterior circulation arteries. Angiography also revealed multiple fistulae between the internal and external carotid arteries. The child is under observation. The pathogenesis and management strategy of multiple intracranial aneurysms are discussed and the relevant literature is briefly reviewed.

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Multiple Cerebral Aneurysms and Cardiac Myxoma

Cited by 93 publications

References 10 publications

The imaging features of neurologic complications of left atrial myxomas

The imaging features of neurologic complications of left atrial myxomas

Transient Ischaemic Attack: A Common Initial Manifestation of Cardiac Myxomas

Multiple Intracranial Aneurysms in a Child with Congenital Cyanotic Heart Disease

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