Multiple Carcinoids in the Stomach with Hypergastrinemia and Type A Gastritis. A Case Report.

Abstract

We have experienced a case of the stomach with hypergastrinemia and type A gastritis withmultiple carcinoids in a 37-year-old woman. An upper gastrointestinal series revealed multiple minute polyps in the upper body of the stomach. All polyps were diagnosed as carcinoid using endoscopic biopsies. She had neither symptom or signs of typical carcinoid disease. The serum gastrin level was as high as 725 pglml. Total gastrectomy was performed, and the diagnosis of multiple gastric carcinoids (sm, no) with type A gastritis was histologically confirmed. After the operation, the serum gastrin level returned to normal, and the patient has been doing well and is disease-free to date at 7 years after the operation. This case suggested that multiple gastric carcinoid lesions may be precipitated by chronic atrophic gastritis accompanying hypergastrinemia. In the treatment of multiple gastric carcinoids with type A gastritis, total gastrectomy with lymph node dissection should be standard operative procedure, in order to resect the fundic gland area completely which could be the origin of carcinoids and endocrine cell micronest.

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

“…In a review of the Japanese literature, Yamamoto et al [3] reported that, between 1975 and 1995, 33 of 35 patients affected with such disease were operated on with a total or subtotal gastrectomy. The purpose of this procedure was to completely resect the fundic gland area which could be the origin of the carcinoids and endocrine cell micronests [6].…”