Multiple carcinoids and endocrine cell micronests in type a gastritis. Their morphology, histogenesis, and natural history

Itsuno, Minoru; Watanabe, Hidenobu; Iwafuchi, Mitsuya; Ito, Seiki; Yanaihara, Noboru; Sato, Koji; Kikuchi, Masanori; Akiyama, Nobuhiro

doi:10.1002/1097-0142(19890301)63:5<881::aid-cncr2820630515>3.0.co;2-k

Cited by 61 publications

(39 citation statements)

References 19 publications

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“…Gastric carcinoid tumors are often found in patients diagnosed as having type A gastritis. In patients with type A gastritis, the development of carcinoids and the widespread hyperplasia of enterochromaffin-like cells are related to atrophic changes of the fundic mucosa and the trophic action of subsequently raised serum gastrin levels [2].…”

Section: Introductionmentioning

confidence: 61%

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

et al. 2005

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Little is known about the natural course of multiple gastric carcinoids associated with type A gastritis. Between 1993 and 2003, we enrolled eight patients, diagnosed as having multiple gastric carcinoids associated with type A gastritis, in a followup program without surgical resection. In these patients, endoscopy showed multiple small polyps on the gastric body, with nonantral atrophic gastritis. Histologically, biopsy specimens obtained from the polyps revealed carcinoid tumors. The serum gastrin level was found to be very high in all patients, and testing for anti-parietal cell antibody was positive in seven. The mean follow-up was 5.8 years (range, 1.5-10.8 years). The levels of serum gastrin increased in all patients, but, endoscopically, the carcinoid tumors did not change in size. Neither hepatic nor lymphatic metastasis was detected on abdominal computed tomography (CT). These patients were free of the development or metastasis of carcinoids, in spite of their continuous hypergastrinemia. It was concluded that multiple gastric carcinoids associated with type A gastritis may be indolent.

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Section: Introductionmentioning

confidence: 61%

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

et al. 2005

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“…This is consistent with our gastric ECC findings. However, it is reported that many gastric CD cases are formed by aggregations of endocrine cell micronests, predominantly composed of enterochromaffinlike cells, caused by the hypertrophic effect of hypergastrinemia, which is induced by extensive atrophic fundic gland mucosal change [18]. In the present study we could not find a CD case associated with the adenocarcinoma component, which presents little evidence for adenocarcinoma precursor cell-derived CD.…”

Section: Discussionmentioning

confidence: 99%

Carcinogenesis of gastric endocrine cell carcinoma: analysis of histopathology and p53 gene alteration

et al. 2003

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“…In other words, the ECM which spread around the carcinoid in the resected specimen do not cause malignant transformation. Considering these facts, ECM can (12).…”

Section: Several Kinds Of Endocrine Cells Including Enterochromaffin mentioning

confidence: 78%

Clinicopathological Study on Endocrine Cell Micronests Associated with Early Gastric Cancer

et al. 2013

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Objective The purpose of this study was to review cases of early gastric cancer associated with Endocrine cell micronests (ECM) and investigate the incidence and characteristics of these lesions. Methods A total of 482 patients who had undergone endoscopic or surgical resection for gastric epithelial neoplasms from April 2008 to March 2010 were enrolled in this study. After detection of ECM in the lamina propria mucosa by histological examination of the resected specimens with hematoxilin-eosin staining, immunostaining was also performed. Clinical manifestation and endoscopic findings, as well as histological findings, were examined. Results Among the 482 patients, 5 (1.0%) had ECM. The histological type of gastric epithelial cancers associated with ECM was tubular adenocarcinoma and carcinoma in situ (Tis) in the WHO classification in all 5 cases. ECM were round to oval or trabecular and located within the area of the early gastric cancer in all the 5 cases. The background gastric mucosa was Type A gastritis in 2 patients and ordinary atrophic gastritis in 2 patients. In the other case, it was difficult to determine the type of gastritis. Conclusion ECM developed not only from the background of Type A gastritis but also from ordinary atrophic gastritis. ECM coexistent with gastric cancer were present in 1.0% of resectable gastric epithelial neoplasms.

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Multiple carcinoids and endocrine cell micronests in type a gastritis. Their morphology, histogenesis, and natural history

Cited by 61 publications

References 19 publications

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis

Carcinogenesis of gastric endocrine cell carcinoma: analysis of histopathology and p53 gene alteration

Clinicopathological Study on Endocrine Cell Micronests Associated with Early Gastric Cancer

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