Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism

Abstract

Differential diagnosis of sudden neurologic deficits and paraplegia in renal patients with secondary HPPT must consider the possibility of brown tumor.

Validity of a Checklist for Hemodialysis Patients Based on the International Classification of Functioning, Disability and Health

“…the Non-anemia group (P = 0.005), suggesting that the influence of physical symptoms and mental symptoms on everyday life was greater in the Anemia group than in the Non-anemia group. Secondary hyperparathyroidism is one of the most important complications in HD patients (13)(14). Severe SHPT can also decrease QOL by causing symptoms of bone pain (13), muscle weakness (14), and itching (15).…”

“…Secondary hyperparathyroidism is one of the most important complications in HD patients (13)(14). Severe SHPT can also decrease QOL by causing symptoms of bone pain (13), muscle weakness (14), and itching (15). Malindretos et al reported that SHPT appears to be associated with poor pain component summary scores and physical component summary scores (16).…”

Brown Tumor Related to Secondary Hyperparathyroidism Leading to Spinal Cord Compression Syndrome

“…The brown tumor is recognized as a non-neoplastic bone reactive process due to increased osteoclastic activity and localized fibroblast proliferation. [1][2][3][4][5][6][7][9][10][11][12][13][14] Its name derives from its reddish brown appearance, due to microhemorrhages and hemosiderin deposition. [1][2][3][4][5] The IRC secondary hyperparathyroidism results from injury of calcitriol (1,25dihydroxyvitamin D3) synthesis, leading to hypocalcemia and phosphate retention and increased production of parathyroid hormone, which can lead to the development of brown tumor.…”

“…Brown tumor, or osteoclastoma, is a benign bone injury, which occurs only in the presence of primary or secondary hyperparathyroidism, with increased incidence in the presence of primary hyperparathyroidism. [1][2][3][4][5][6] Even though infrequent, the relationship of brown tumor with secondary hyperparathyroidism is well established. [1][2][3][4][5][6] Palavras-chave ► hiperparatireoidismo secundário ► compressão da medula espinhal ► tumor de células gigantes do osso…”

“…Although secondary hyperparathyroidism is a frequent complication of chronic renal failure (CRF) in dialysis-dependent patients, brown tumor, as one of its manifestations, is relatively uncommon, with an incidence of 1.5 to 13%. [1][2][3][4][5][6] The tumor affects mainly the jaw, hands, feet, and facial bones, as well as, rarely, other skeletal sites. [1][2][3]7 Clinically, it presents as a solitary, lytic and expansive lesion, and it may infrequently extend to the extra bone adjacent tissues.…”