Multiple brain metastases from adenoid cystic carcinoma of the parotid gland

Kazumoto, Kiyoshi; Hayase, Nobuaki; Kurosumi, Masafumi; Kishi, Kiyozo; Uki, Jiro; Takeda, Fumikazu

doi:10.1016/s0090-3019(97)00341-8

Cited by 26 publications

(14 citation statements)

References 25 publications

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“…Recurrence may relate to perineural or perivascular invasion with occult cells beyond negative resection margins12, 39 or ACC may seed distally very early in tumorigenesis. Perineural involvement is common, it increases chances of recurrence, and could account for the 14% to 22% of patients with head and neck ACCs who develop intracranial tumor extension 40. Recent data also suggests intraneural, rather than perineural, invasion has a larger impact on survival in head and neck ACC 41.…”

Section: Introductionmentioning

confidence: 99%

“…The most common sites of metastases are the lungs followed by bone, liver, skin, breast, and rarely the brain 44. Intracranial disease, while rare, usually results from direct tumor extension or invasion along cranial nerves rather than hematogenous spread 40, 46. Patients who develop metastatic ACC are considered incurable, except in the rare case in which single or oligometastatic disease is resectable 38.…”

Section: Introductionmentioning

confidence: 99%

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Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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BackgroundAdenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed.MethodsA search of articles in PubMed and of abstracts from national meetings was performed regarding ACC.ResultsRecent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare.ConclusionACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. 38: 620–627, 2016

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Chakraborty²,

et al. 2015

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“…12 In the later stages of the disease, distant metastasis is a common complication with lungs and bone being the most common sites. 13 Less commonly, metastasis can also involve other organs such as the liver, 14 skin, 15 optic disc, 16 choroid, 17 brain, 18 spine, 19 and kidney. 20 A protracted course of many years with multiple local recurrences and late appearance of metastatic disease is the characteristic clinical course for these slow-growing tumors.…”

Section: Discussionmentioning

confidence: 99%

Extra-salivary gland presentations of adenoid cystic carcinoma: A report of three cases

et al. 2006

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Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area. When ACC presents outside of these locations, the diagnosis may become more challenging. We describe three cases of ACC presenting in extra-salivary gland sites. Two cases were metastatic; in case 1 the initial presentation was widespread bony metastasis of unknown primary origin. The other metastatic case (case 2) was from a patient presenting with a pleural effusion and a history of previously treated metastatic pulmonary ACC. The pleural effusion cytology was unusual in that exfoliated ACC cells were present in the effusion itself, a rare occurrence. Case 3 was a primary bronchial ACC. In conclusion, ACC can present in various body sites and cytologists must consider this neoplasm when presented with a basaloid carcinoma of uncertain origin.

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“…Pour cela, tout bilan radiologique d'un CAK, doit rechercher les signes d'infiltration péri-nerveuse ce qui permettra une exérèse chirurgicale la plus complète et une meilleure définition du champ d'irradiation. L'IRM permet, avec une haute sensibilité et spécificité (12), de mettre en évidence la diffusion le long des gaines vasculo-nerveuses. Les signes d'une infiltration péri-neurale sont l'épaississement global d'un nerf, l'expansion concentrique des trous de la base, la disparition de lʼhypo-signal de la citerne trigémi-nale remplacée par un iso-signal tumoral, l'atrophie des muscles masticateurs et la disparition de la graisse dans la fosse ptérygo-palatine (13 ,10,14).…”

Section: Mnejja M Et Alunclassified

L'atteinte du sinus caverneux dans le carcinome adenoïde systique

Mnejja¹,

Hammami²,

Kolsi³

et al. 2011

Journal Tunisien d'ORL Et De Chirurgie Cervico-Faciale

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Les carcinomes adénoïdes kystiques cervico-faciaux sont des tumeurs épithéliales malignes qui se développent, essentiellement, au niveau des glandes salivaires principales et accessoires. L'envahissement du sinus caverneux et de la base du crâne a été rapporté dans la littérature. Il serait dû soit à une extension de proche en proche de la tumeur, soit à une extension péri-neurale empruntant principalement la voie trigéminale, soit à une extension par voie hémato-gène. A travers deux observations, nous discutons les méca-nismes d'atteinte du sinus caverneux et de la base du crâne dans les carcinomes adénoïdes kystiques. C A S C L I N I Q U E S RESUME Introduction : Les carcinomes adénoïdes kystiques (CAK) cervico-faciaux sont des tumeurs épithéliales malignes, déve-loppées au niveau des glandes salivaires. L'envahissement du sinus caverneux et de la base du crâne a été rapporté dans la littérature. Il serait essentiellement dû à une extension péri-neurale. Observations : Nous rapportons dans cet article deux observations de CAK envahissant le sinus caverneux. Le premier sʼest développé au niveau de la glande parotide gauche, a envahi la fosse infra temporale gauche puis a emprunté la voie trijéminale pour atteindre le sinus caverneux homolatéral. Le deuxième cas était un CAK de la glande submandibulaire gauche. Une exérèse chirurgicale étendue a été réalisée suivie dʼune chimio-radiothérapie mais lʼévolution a été émaillée par lʼatteinte du sinus caverneux homolatéral après deux ans de la fin du traitement. Discussion : Le CAK est une tumeur maligne de haut grade, à agressivité surtout locorégionale avec une forte tendance à la récidive. Lʼinfiltration péri-nerveuse constitue une voie d'extension typique pour le CAK. Les nerfs mandibulaire, maxillaire et facial sont les plus fréquemment incriminés dans cette modalité extensive vers le sinus caverneux et la base du crâne. L'IRM permet, avec une haute sensibilité et spécificité, de mettre en évidence la diffusion le long des gaines vasculo-nerveuses. La chirurgie, en cas d'atteinte du sinus caverneux, est refutée par la majorité des auteurs. La radiothérapie est une alternative thérapeutique. La place de la chimiothérapie est minime. Le pronostic des CAK envahissant la base du crâne est en général mauvais vue la fréquence des récidives locales et le risque majeur de dissémina-tion systémique. Mots clés: Carcinome adénoïde kystique, sinus caverneux, base du crâ0ne, infiltration périneurale. OBSERVATIONS SUMMARYIntroduction: Head and neck adenoid cystic carcinoma (ACC) is a malignant epithelial neoplasm, developing from salivary gland tissue. Cavernous sinus and skull base invasion by perinervous spread is a particular behavior of this tumor entity. We report two cases of cavernous sinus invasion. Cases report: The first one was originated in the parotid gland, invaded infratemporal fossa and extended to cavernous sinus through perineural infiltration along trigeminal nerve. Second case of ACC was developed in submandibular gland. An invasion of cavernous sinus was ...

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Multiple brain metastases from adenoid cystic carcinoma of the parotid gland

Cited by 26 publications

References 25 publications

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

Extra-salivary gland presentations of adenoid cystic carcinoma: A report of three cases

L'atteinte du sinus caverneux dans le carcinome adenoïde systique

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