Multiple bout rTMS on spatial working memory: A comparison study of two cortical areas

Pearce, Alan J.; Lum, Jarrad A. G.; Seth, Shikha; Rafael, Olivia; Hsu, Chih‐Chin; Drury, Hannah G. K.; Tooley, Gregory

doi:10.1016/j.biopsycho.2014.05.002

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…We did not observe evidence of improved WM performance following multi-day parietal stimulation. Our findings are in contrast to a study by Pearce et al (2014) which reported improved spatial WM performance following multi-day parietal rTMS. There are a number of methodological differences between studies which may have contributed to these discrepant outcomes.…”

Section: Discussioncontrasting

confidence: 99%

“…We did not observe evidence of improved working memory performance following multi-day parietal stimulation. Our findings are in contrast to a study by Pearce et al (2014) which reported improved spatial working memory performance following multi-day parietal rTMS.…”

Section: Multi-day Rtms and Working Memorycontrasting

confidence: 99%

“…A number of studies have demonstrated transient improvements in WM following a single dose of rTMS to parietal cortex (Hamidi et al, 2008; Luber et al, 2007; Yamanaka et al, 2010), as well as longer term improvements following multi-day rTMS (6 sessions; Pearce et al, 2014). We did not observe evidence of improved WM performance following multi-day parietal stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have demonstrated transient improvements to working memory performance following a single dose of rTMS to parietal cortex (Hamidi et al, 2008;Luber et al, 2007;Yamanaka et al, 2010), as well as longer term improvements following multi-day rTMS (6 sessions; Pearce et al, 2014). In contrast, a recent study (Beynel et al, 2020) applied 5 Hz rTMS to a similar parietal target during the 5-s delay phase of a delayedresponse alphabetisation task (their average MNI coordinate x = -41, y = -64, z = 42) and…”

Section: Multi-day Rtms and Working Memorymentioning

confidence: 99%

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The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

Hendrikse

Thompson

Suo

et al. 2020

Preprint

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Working memory (WM) refers to the capacity to temporarily retain and manipulate finite amounts of information; a critical process in complex behaviours such as reasoning, comprehension, and learning. This cognitive function is supported by a parietal-prefrontal network and linked to the activity of key brain neurotransmitters, such as gamma-aminobutyric acid (GABA). Impairments in WM are seen in a range of psychiatric and neurological disorders, and there are currently no effective methods of remediating WM deficits. In this study, we analysed secondary outcome measures from a trial investigating the effects of multi-day rTMS on cognition. Participants received four days of 20 Hz rTMS to an individualised region of left parietal cortex in one week, and an individualised region of pre-supplementary motor area (pre-SMA) in a separate week. We assessed changes to WM function before and after each week of stimulation (N = 39), and changes to GABA concentration before and after stimulation in week one using MR spectroscopy (N = 18 per stimulation condition). We hypothesised that multi-day parietal rTMS would enhance WM and reduce GABA concentration, but this was not observed. Instead, we report some evidence of improved WM function and increased GABA concentration following pre-SMA rTMS, although this effect was variable across individuals. Additionally, we found that higher cardiorespiratory fitness was associated with greater WM improvement following pre-SMA stimulation. While there are a number of factors known to influence the response to rTMS, increasing cardiorespiratory fitness may provide a novel approach to enhance cognitive outcomes. Given the clinical utility of both exercise and rTMS, future studies are required to determine whether additive effects may be achieved when applied in tandem.

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Section: Discussioncontrasting

confidence: 99%

Section: Multi-day Rtms and Working Memorycontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Multi-day Rtms and Working Memorymentioning

confidence: 99%

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The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

Hendrikse

Thompson

Suo

et al. 2020

Preprint

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“…A temporal-frontal circuit is considered to be related to pattern recognition and a parietal-frontal circuit is considered to be related to spatial information (Wager and Smith, 2003). Many imaging studies have shown that the ventrolateral prefrontal cortex is consistently activated during WM for object information (Prabhakaran et al, 2000; Mohr et al, 2006b), however, evidence from neuroimaging studies indicated that the dorsolateral prefrontal cortex (dlPFC) (Yin et al, 2013; Pearce et al, 2014) was significantly activated during spatial WM tasks, and the superior frontal sulcus has also been proven to be a critical region for spatial WM (Zarahn et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity

Ren

Zhang

et al. 2019

Front. Hum. Neurosci.

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In working memory (WM), the ability to concurrently integrate different types of information and to maintain or manipulate them promotes the flow of ongoing tasks. WM is a key component of normal human cognition. In this study, we applied a combined voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis to investigate the relationship between the ability of object and spatial working memory (WM), and regional gray matter density (GMD), as well as intrinsic functional connectivity. The VBM analysis showed a positive correlation between the individual difference of object WM and GMD in the right middle occipital gyrus (MOG) and the left superior temporal gyrus (STG), which are responsible for coding object information and processing the shape of an object. The individual difference of the spatial WM was positively related to GMD in the right middle frontal gyrus (MFG) located in the dorsolateral prefrontal cortex (dlPFC), which confirmed that it is an important region for memory stores and maintains WM spatial representations. Further functional connectivity analysis revealed that the individual difference of object WM was significantly correlated with the rsFC of right intraparietal sulcus (IPS) – left postcentral gyrus (PostCG)/right precentral gyrus (PreCG)/left Supplementary Motor Area (SMA). While the capacity of spatial WM was significantly associated with the FC strength of the left dlPFC – left precuneus, right dlPFC – right MFG, and the left superior frontal sulcus (SFS) – left SMA/ right inferior parietal lobe (IPL). Our findings suggest that object WM is associated with the structure and functional organization of the brain regions involved in the ventral pathway (occipital – temporal regions) and the capacity of spatial WM is related to the dorsal pathway (frontal – parietal regions).

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Cognitive Effects Following Offline High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) in Healthy Populations: A Systematic Review and Meta-Analysis

Nikolin

Samaratunga

et al. 2023

Neuropsychol Rev

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High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a commonly used form of rTMS to treat neuropsychiatric disorders. Emerging evidence suggests that ‘offline’ HF-rTMS may have cognitive enhancing effects, although the magnitude and moderators of these effects remain unclear. We conducted a systematic review and meta-analysis to clarify the cognitive effects of offline HF-rTMS in healthy individuals. A literature search for randomised controlled trials with cognitive outcomes for pre and post offline HF-rTMS was performed across five databases up until March 2022. This study was registered on the PROSPERO international prospective protocol for systematic reviews (PROSPERO 2020 CRD 42,020,191,269). The Risk of Bias 2 tool was used to assess the risk of bias in randomised trials. Separate analyses examined the cognitive effects of excitatory and inhibitory forms of offline HF-rTMS on accuracy and reaction times across six cognitive domains. Fifty-three studies (N = 1507) met inclusion criteria. Excitatory offline HF-rTMS showed significant small sized effects for improving accuracy (k = 46, g = 0.12) and reaction time (k = 44, g = -0.13) across all cognitive domains collapsed. Excitatory offline HF-rTMS demonstrated a relatively greater effect for executive functioning in accuracy (k = 24, g = 0.14). Reaction times were also improved for the executive function (k = 21, g = -0.11) and motor (k = 3, g = -0.22) domains following excitatory offline HF-rTMS. The current review was restricted to healthy individuals and future research is required to examine cognitive enhancement from offline HF-rTMS in clinical cohorts.

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Multiple bout rTMS on spatial working memory: A comparison study of two cortical areas

Cited by 8 publications

References 19 publications

The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

The effects of multi-day rTMS and cardiorespiratory fitness on working memory and local GABA concentration

The Different Brain Mechanisms of Object and Spatial Working Memory: Voxel-Based Morphometry and Resting-State Functional Connectivity

Cognitive Effects Following Offline High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) in Healthy Populations: A Systematic Review and Meta-Analysis

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