Multiple bilateral oncocytomas of the native kidneys following renal transplantation: report of a rare case and review of the literature

Vernadakis, Spiridon; Karaolanis, Georgios; Moris, Demetrios; Zavvos, Vasileios; Liapis, George; Zavos, G.

doi:10.1186/1477-7819-11-119

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…Vernadakis et al (9) have reported bilateral oncocytomas of the native kidneys in a renal transplant recipient. Due to the close association between oncocytoma and RCC, as well as reports on immunological disturbances in RCC and oncocytoma patients, the hypothesis of immune system involvement in the pathogenesis of these two tumors appears to be reasonable.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: A case report

Zabrocka

Sierko

Jelski³

et al. 2016

Molecular and Clinical Oncology

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Abstract. We herein report the case of a 74 year-old woman with a diffuse large B-cell lymphoma and bilateral renal masses identified on computed tomography scans during the initial staging process. Following partial bilateral nephrectomy, histopathological examination revealed renal cell carcinoma (RCC) and oncocytoma in the left and the right kidneys, respectively. Shortly afterwards, lymphoma of the left palatine tonsil was diagnosed and the patient received chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP regimen), followed by radiotherapy. Due to metastasis of the RCC to the right breast, pancreas and the area of the left psoas major muscle, systemic treatment with pazopanib was commenced. To the best of our knowledge, this is the first reported case of simultaneous diagnosis of non-Hodgkin lymphoma (NHL), RCC and oncocytoma. The aim of this study was to review the related literature, discuss issues regarding the management of this unusual case and identify possible common etiopathological mechanisms underlying the simultaneous occurrence of NHL, RCC and oncocytoma.

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Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: A case report

Zabrocka

Sierko

Jelski³

et al. 2016

Molecular and Clinical Oncology

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“…Unilateral tumors make up 95% of cases of renal oncocytoma, and multiple tumors make up 5%. [ 3 ] Renal oncocytomas arise from the intercalated cells of the kidney's distal collecting tubules. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…They represent approximately 3–7% of all primary renal solid tumors and occur most frequently in males (1.6:1). [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Bladder leiomyoma in male patient presenting with renal oncocytoma: Are the two conditions related?

et al. 2016

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“…Renal oncocytoma (RO) is the second most common benign renal neoplasm which arises from the intercalated collecting duct cells in the kidney [1, 2]. It has an estimated incidence of 3 to 7% of all primary renal masses [3, 4] and comprises 10 to 15% of enhancing small renal masses (≤4 cm in diameter) [5].…”

Section: Introductionmentioning

confidence: 99%

Bilateral benign renal oncocytomas and the role of renal biopsy: single institution review

et al. 2017

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BackgroundThe goal was to assess the natural history and management of patients with pathologically proven bilateral (synchronous) RO after undergoing initial partial nephrectomy (PN).MethodsAll patients underwent either robotic/laparoscopic or open PN by two experienced genitourinary oncologists from 2005–2013. Final pathology was determined by surgical excision, CT-guided percutaneous core biopsy (CT-biopsy) or fine needle aspiration (FNA). Patient demographics, tumor characteristics (pathologic data, location, size) type of surgery, pre/post estimated glomerular filtration rate (eGFR) and surgical complications were recorded.ResultsTwelve patients were identified with bilateral RO. Median age at the time of surgery was 68 years (46–77) (Table 1). The median size of the largest tumor(s) resected was 2.75 cm (1.5–5.5 cm) and second largest tumor(s) was 1.75 cm (1.0–4.0 cm). Four patients underwent bilateral staged PN and one patient underwent simultaneous bilateral PN (horseshoe kidney). Two patients underwent RFA at the time of biopsy of the contralateral mass after PN. Five patients underwent CT-bx/FNA (5/5) of the contralateral mass followed by active surveillance.Mean follow up was 34 months. There was no significant change in median creatinine pre- and post-operatively. One patient was lost to follow up and one patient died of unknown causes 5 years post-operatively. eGFR decreased an average of 16.96% post-operatively, including a single patient whose eGFR increased by 7.8% after surgery and a single patient whose eGFR did not change (Table 2).ConclusionsPatients with bilateral renal masses and pathologically proven RO can be safely managed with active surveillance after biopsy confirmation of the contralateral mass.

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Multiple bilateral oncocytomas of the native kidneys following renal transplantation: report of a rare case and review of the literature

Cited by 6 publications

References 23 publications

Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: A case report

Simultaneous occurrence of non-Hodgkin lymphoma, renal cell carcinoma and oncocytoma: A case report

Bladder leiomyoma in male patient presenting with renal oncocytoma: Are the two conditions related?

Bilateral benign renal oncocytomas and the role of renal biopsy: single institution review

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