Multiple Bilateral Circumscribed Breast Masses Detected at Imaging: Review of Evidence for Management Recommendations

Multiple bilateral breast masses due to lymphoma metastases: A report of 2 cases highlighting the mammographic and sonographic features

“…The imaging and management guidelines for solitary breast masses has wide consensus, whereas those on bilateral breast masses can at its best, be considered as still evolving and somehow, most Authors tend to postulate that multiple breast masses are more frequently benign cysts or fibroadenomas [ 5 , 6 ]. Multiple masses are definitely infrequent and known to be detected only in 1.7% of routine screening mammograms and in 6.2% of breast screening US examinations performed by physicians for women with elevated risk of cancer [5] . Therefore, the possibility for secondary metastases as an etiology for multiple breast masses is relatively underemphasized.…”

“…The differential diagnosis for bilateral multiple breast masses to be considered at imaging studies, includes multiple benign fibroadenomas in young women below 40 years and multiple benign cysts in both younger women and perimenopausal women [ 5 , 6 ]. Clinical correlation with a history of rapid enlargement in the multiple masses is an important clue towards multiple breast metastases [ 1 – 3 ].…”

Reducing false-positive biopsies with deep neural networks that utilize local and global information in screening mammograms

“…Meanwhile, models built for the breast-level classification task cannot provide independent risk estimations for multiple areas of interests appearing in the same breast. It is common to encounter cases with multiple findings [19]. For example, multiple bilateral circumscribed breast masses are detected in approximately 1.7% of routine screening mammograms [20].…”