Multiple basal cell carcinomas arising in a verrucous epidermal nevus

Zheng, Liqiang; Huang, Yong; Qu, Yan-Jing; Zhang, Yuanhong; Han, Xiang-chun

doi:10.1111/1346-8138.12110

Cited by 11 publications

(10 citation statements)

References 5 publications

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“…epidermal nevus syndrome) (3,28). Several other changes have been reported in verrucous epidermal nevi, such as Bowen's disease, verrucous and adnexal carcinomas (3,29), basal cell (30) and squamous cell carcinomas (31,32) within epidermal nevi. However, it has not yet been claryfi ed whether these represent age and/ or site-dependent diff erences in the same condition or diff erent nevi (3).…”

Section: Discussionmentioning

confidence: 93%

Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

Ljubisavljević

Zlatanović

Milenkovic

et al. 2015

Serbian Journal of Dermatology and Venereology

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Verrucous epidermal nevi are noninfl ammatory, congenital, cutaneous hamartomas composed of keratinocytes, abnormal clone(s) of cells that refl ect genetic mosaicism arising from different somatic mutations. Some of these mutations are well recognized, but some are still unidentifi ed. Molecular techniques are used for identifi cation and classifi cation of molecular causes of certain epidermal nevi, whereas all verrucous epidermal nevi are divided into epidermolytic and non-epidermolytic types. They are typically present at birth, but may appear during childhood, even later. Their prevalence in adults ranges from 0.1 to 0.5%, equally affecting both sexes, and about 1 in 1000 newborns. Warty, brown papules without infl ammation distinguish verrucous nevi from other epidermal nevi, while presence at birth and persistance distinguish verrucous epidermal nevi from linear viral warts. Epidermolytic and non-epidermolytic verrucous epidermal nevi are almost always hard to distinguish, except by histology. As a rule, verrucous epidermal nevi are asymptomatic, they have a benign course, except occasionally, and therapy is mostly used for cosmetic reasons. Simple excision is usually the treatment of choice. Topical agents are rarely curative, as well as surgery which is associated with relapses, unless both epidermis and the underlying dermis are removed or destroyed at the same time. We present a case of an otherwise healthy 21-year-old female patient, who presented with a solitary congenital verrucous caulifl ower-like lesion in the right zygomatic region of the face. The lesion was present from birth. Due to its gradual growth during years, the lesion became a great esthetic and functional problem for this young patient. There was no family history of similar or any other tumorous skin lesions in the family. On examination, the patient had a solitar unilateral, well defi ned yellowish caulifl ower-like verrucous lesion confi ned to the right malar side of the face. The lesion was distributed along the lines of Blaschko extending horizontally, from its wider 1.5 cm caulifl ower-like part on the right zygomatic region, towards its tail-like 0.5 cm thick end on the preauricular region, in approximately 3 cm long tail-like manner without crossing the midline. Since the patient refused biopsy, no exact differentiation between epidermolytic and non-epidermolytic nevi was possible. The diagnosis of verrucous epidermal nevus was based on history and clinical presentation, as a diagnosis of exclusion. Due to the fact that patients with epidermolytic verrucous epidermal nevi are at risk of parenting a child with bullous ichthyosiform erythroderma, the patient was counseled on this risk, and on the possibility of fi rst-trimester antenatal diagnosis. The lesion was successfully treated by radio-wave surgery.

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Section: Discussionmentioning

confidence: 93%

Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

Ljubisavljević

Zlatanović

Milenkovic

et al. 2015

Serbian Journal of Dermatology and Venereology

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“…To date, few cases have been reported regarding this rare entity of basal cell carcinoma in association with epidermal naevus (De et al 2007;Zheng et al 2013;Mordovtseva 2015;Viana et al 2015). Presentation of basal cell carcinoma within an epidermal naevus is similar to classical presentation of basal cell carcinoma of the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Based on other case reports, the treatment for basal cell carcinoma in association with epidermal naevus is mainly excision of the entire lesion with adequate skin margin 3 -5 mm with closure of skin flap if necessary (De et al 2007;Zheng et al 2013). All of the cases reported no recurrence during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma Arising from an Epidermal Naevus

Mohammed¹,

Azahsyahrina²,

Moonyza³

et al. 2017

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ABSTRAK Epidermal naevus adalah hamartoma kulit kongenital yang benigna. Kami mengetengahkan kes yang jarang ditemui iaitu epidermis naevus dengan transformasi ABSTRACTEpidermal naevus is a congenital cutaneous hamartoma with a benign course. We highlight a rare case of epidermal naevus with concurrent basal cell carcinoma. A 79-year-old male had a skin biopsy at our centre for an enlarging skin nodule within a linear papular lesion measuring 2 x 4 cm at the left side of his neck, which was later diagnosed as basal cell carcinoma arising from an epidermal naevus. PIK3CA mutation is attributed to basal cell carcinoma which suggests the basal cell carcinoma component is independent of the epidermal naevus component. Clinicians and pathologists must be aware of possible malignant changes that might arise in an epidermal naevus.

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“…There are about 13 reports of squamous cell carcinoma [2, 3] and isolated cases of Bowen's disease [4], keratoacanthoma [5], apocrine multifocal papillary adenoma [6] and malignant eccrine poroma [7] arising from verrucous epidermal nevi. There are very few reports describing BCC appearing on verrucous epidermal nevi [8, 9, 10, 11, 12, 13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma Arising on a Verrucous Epidermal Nevus: A Case Report

Viana¹,

Aguinaga²,

Marinho³

et al. 2015

Case Rep Dermatol

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We report a case of basal cell carcinoma that appeared from an epidermal verrucous nevus in a 61-year-old patient. The onset of basal cell carcinoma in sebaceous nevi, basal cell nevi and dysplastic nevi is relatively common, but it is rarely associated with epidermal verrucous nevi. There is no consensus on whether the two lesions have a common cellular origin or whether they merely represent a collision of two distinct tumors. Since this association - as with other malignant tumors - is rare, there is no need for prophylactic removal of epidermal verrucous nevi.

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Multiple basal cell carcinomas arising in a verrucous epidermal nevus

Cited by 11 publications

References 5 publications

Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

Basal Cell Carcinoma Arising from an Epidermal Naevus

Basal Cell Carcinoma Arising on a Verrucous Epidermal Nevus: A Case Report

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