Multiple basal cell carcinoma associated with keratoacanthoma

Lee, Hyung Soon; Lee, Seung Hun; Lee, Sungnack; Ahn, Sung Ku; Lee, H S; Han, Sangwoo; Lee, S H; Lee, S

doi:10.3349/ymj.1992.33.3.277

Cited by 9 publications

(8 citation statements)

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“…2 Around the world, primary and secondary prevention efforts for melanoma have produced conflicting results. While some groups have shown that screening was effective in increasing the proportion of thin tumors, 10–13 stabilizing the incidence of thick tumors, 11,14 and improving survival, 13,15 others have shown that the proportion of thick IMMs and fatal incidence has remained unaffected by screening efforts. 3,12,14,16–19 …”

Section: Introductionmentioning

confidence: 99%

Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

Wei

Qureshi

Han

et al. 2016

Journal of the American Academy of Dermatology

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Background The incidence of melanoma in situ is rising, but little is known about its characteristics. Objective To determine trends in diagnosis and clinical features of melanoma in situ. Methods Incident cases of melanoma were collected prospectively from the Nurses’ Health Study from 1976–2010 and Health Professionals Follow-up Study from 1986–2010. Results MIS incidence increased from 2 to 42 per 100,000-person-year (100KPY) among women, and from 11 to 73 per 100KPY among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on upper half of the body (p<0.001). Invasive melanomas were diagnosed at a younger age than melanoma in situ (p<0.001), and were more likely to be found on the lower extremities than in situ melanomas (p<0.001). Limitations This is a strictly descriptive study without examination into mechanisms. Conclusion We found epidemiologic and clinical differences in in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite increase in detection of in situ relative to invasive lesions further highlight the need to improve invasive melanoma-specific clinical screening features.

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Section: Introductionmentioning

confidence: 99%

Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

Wei

Qureshi

Han

et al. 2016

Journal of the American Academy of Dermatology

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“…Nonsyndromic, but hereditary multiple BCCs have been reported in literatures, but they were ruled out based on the negative family history [ 9 ]. There was no history of exposure to arsenic, irradiation, dry ice and no evidence of keratoacanthoma or xeroderma pigmentosum [ 10 11 ]. Cytochrome P450 (CYP2D6) genotypes and Glutathione S transferase (GSTM1 and GSTT1) are included with a multiple presentation phenotypes of BCC and have been introduced in the literature [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Nonsyndromic Multiple Basal Cell Carcinomas

Kim

Jun

2017

Arch Craniofac Surg

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Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. All lesions were completely removed by surgery. The pathologic results showed lesions consistent with BCC and some lesions consistent with actinic keratosis. After 8 months, the patient presented with skin lesions in bilateral temporal areas and left cheek area. Surgical excision of the lesions was performed, and the biopsy results were squamous cell carcinoma in situ and actinic keratosis. In Case 2, a 43-year-old woman presented with multiple skin lesions on the face, scalp, right chest, abdomen and right leg. All lesions were completely removed by surgery. Pathologic evaluation confirmed the diagnosis of BCC. BCC is rarely metastatic, but it can lead to severe disfiguration or destruction. It is important to diagnose and treat BCC at an early stage.

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“…[6][7][8] Individuals with blonde hair, blue eyes have increased risk of developing basal cell carcinoma. 5,7,[9][10][11][12][13][14][15][16][17] Basal cell carcinoma is a slow-growing tumor of non-keratinizing cells originating in the basal layer of interfollicular epidermis. 2 It is rarely metastasizing tumour with the rate of metastasis being <0.1 per cent.…”

Section: Introductionmentioning

confidence: 99%

Multiple-lesion, non-familial basal cell carcinoma-An interesting oddity

Kadam,

Pardeshi,

Basalingappa

et al. 2023

JDPO

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Basal cell carcinoma (BCC) is the most common primary carcinoma of skin, which accounts for three-fourth of all primary skin tumours. Basal carcinoma occurs commonly as a single lesion, though occasionally it can occur as Multiple lesions, which may occur in close association with heredofamilial conditions such as nevoid basal cell carcinoma syndrome (Gorlin’s syndrome), Bazex syndrome, Rombo syndrome, and unilateral basal cell nevus syndrome. The case of multiple basal cell carcinomas being presented here is unique in its occurrence inasmuch as it is not associated with heredofamilial conditions, and despite not being associated with heredofamilial conditions there is occurrence of multiple basal carcinomas in a patient in a tertiary care hospital in a dominantly tribal region. The patient has no family history of genodermatosis that could increase the incidence of multiple basal cell carcinomas such as xeroderma pigmentosum, and no history of other predisposing conditions including actinic keratosis, Bowen’s Disease, leukoplakia, Erythroplasia of Queyrat, keratoacanthoma, radiation dermatitis and exposure to arsenicals, psoralen and other photosensitizing medications. However, the patient had history of having raised macules over the face which were diagnosed as seborrheic keratosis.

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Multiple basal cell carcinoma associated with keratoacanthoma

Cited by 9 publications

References 0 publications

Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study

Nonsyndromic Multiple Basal Cell Carcinomas

Multiple-lesion, non-familial basal cell carcinoma-An interesting oddity

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