Multiple asymptomatic scrotal nodules

Madan, Vishal; Gangopadhyay, M.; Dawn, G.

doi:10.1111/j.1365-2230.2008.02698.x

Cited by 3 publications

(2 citation statements)

References 8 publications

(19 reference statements)

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“…No Koebner phenomenon was noted. Essentially all areas of the body could be affected by PGA, even on the ears, 5 soles, 6 palms, 7 and in the genital region, 8 whereas the extensor surfaces of both extremities and the dorsa of the hands and fingers were involved in around half of the patients. About 60% of PGA cases were disseminated, while single lesion 9 only presented in 7 (9%) cases, which was the same as that reported by Penas et al 3 Nine PGA cases (18%) were diagnosed with DM.…”

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confidence: 99%

Activating HRAS Mutation in Nevus Spilus

Sarin

McNiff

Kwok

et al. 2014

Journal of Investigative Dermatology

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A 34-year-old Chinese man presented with an 11-year history of gradually progressive papular lesions scattered over his upper extremities and trunk. These asymptomatic papules initially started on the dorsa of his hands and fingers. Individual papule developed a central umbilication with scale or crust, and then regressed over the next 1-2 months, usually leaving a white punctate scar. Some papules with a central pin point-sized, black horny plug were observed. Gradually, lesions increased and involved bilateral forearms, right arm and trunk. There was no history of trauma, insect bites or excess solar exposure. Physical examination revealed multiple 3-6 mm, annular or arciform, flesh-coloured firm papules with central umbilicated crust or scale mainly involving the right arm and back (Fig. 1a). There were several 1-2 mm atrophic hypopigmented scars on the dorsa of his hands. A biopsy from the umbilicated papule on the back showed findings compatible with PGA (Fig. 1b). Laboratory investigations including complete blood cell count, blood biochemistry, urinalysis and chest X-ray were normal. Those lesions resolved with treatments of liquid nitrogen, and topical steroids within 3 months.The eruptions of PGA were classified into papular perforating type (P-type) and ulcerative perforating type (U-type). 4 The localization of lesions were divided into localized PGA (LPGA) and generalized PGA (GPGA), and cases with extensive lesions over extremities only were regarded as disseminated. 3 The comparison of clinical features of GPGA and LPGA variants and P-and U-type variants of 78 cases reviewed were summarized in Table 1. The entire group included 78 patients (49 female, 29 male), and data regarding age of onset and evolution time of PGA were not available in five cases. The mean age of onset was 32 years (range, 53 days to 72 years). Patients classified as P-type had a lower mean age of onset than U-type (29 vs. 48 years, P < 0.001). Furthermore, it was significantly lower in female than that in male (28 vs. 39 years, P < 0.05). The mean evolution time of PGA was 3 years (range, 1 month to 30 years), and it was significantly shorter in LPGA than GPGA (2.3 vs. 4.6 years, P < 0.05). The most common clinical presentation of PGA was flesh to redcoloured, 1-7 mm papules with central crust or scale, and/or umbilication.

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confidence: 99%