2014
DOI: 10.1016/j.jmb.2013.10.033
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Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

Abstract: Several members of the APOBEC3 family of cellular restriction factors provide intrinsic immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F, APOBEC3G, and APOBEC3H haplotypes II, V, and VII provide protection against HIV-1Δvif through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome. HIV-1 counteracts APOBEC3 proteins by encoding the viral protein Vif, which contains distinct domains that specificall… Show more

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Cited by 184 publications
(220 citation statements)
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References 276 publications
(483 reference statements)
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“…Several human APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3) proteins, notably APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H, have the capacity to restrict human immunodeficiency virus type 1 (HIV-1) replication (Albin & Harris, 2010;Desimmie et al, 2014;Feng et al, 2014;Kitamura et al, 2011;Refsland & Harris, 2013). These restriction factors are incorporated into the progeny virions and enzymically convert viral cDNA cytosines to uracils during reverse transcription, which can debilitate viral function (Albin & Harris, 2010;Desimmie et al, 2014;Feng et al, 2014;Kitamura et al, 2011;Refsland & Harris, 2013).…”
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confidence: 99%
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“…Several human APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3) proteins, notably APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H, have the capacity to restrict human immunodeficiency virus type 1 (HIV-1) replication (Albin & Harris, 2010;Desimmie et al, 2014;Feng et al, 2014;Kitamura et al, 2011;Refsland & Harris, 2013). These restriction factors are incorporated into the progeny virions and enzymically convert viral cDNA cytosines to uracils during reverse transcription, which can debilitate viral function (Albin & Harris, 2010;Desimmie et al, 2014;Feng et al, 2014;Kitamura et al, 2011;Refsland & Harris, 2013).…”
mentioning
confidence: 99%
“…These restriction factors are incorporated into the progeny virions and enzymically convert viral cDNA cytosines to uracils during reverse transcription, which can debilitate viral function (Albin & Harris, 2010;Desimmie et al, 2014;Feng et al, 2014;Kitamura et al, 2011;Refsland & Harris, 2013). Although original studies focused on human APOBEC3G (Harris et al, 2003;Mariani et al, 2003;Sheehy et al, 2002;Zhang et al, 2003), subsequent work revealed that all placental mammals have APOBEC3 enzymes (Münk et al, 2012), albeit different numbers, and that these enzymes have the potential to attenuate the infectivity of a broad spectrum of viruses, including simian immunodeficiency virus (SIV) (Mariani et al, 2003), feline immunodeficiency virus (FIV) (Münk et al, 2008;Zielonka et al, 2010), bovine immunodeficiency virus (BIV) (LaRue et al, 2010) and small ruminant lentiviruses (SRLVs; e.g.…”
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confidence: 99%
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“…Together they play an important role in preventing the replication and spread of a wide range of viruses, retroviruses and retroelements (reviewed by Desimmie et al, 2014;Harris & Dudley, 2015;Koito & Ikeda, 2013). A3F and A3G are potent and well-characterized members of the A3 family that are mostly recognized for their roles in mutating and restricting the infection of human immunodeficiency virus type 1 (HIV-1).…”
Section: Introductionmentioning
confidence: 99%
“…A3F and A3G are potent and well-characterized members of the A3 family that are mostly recognized for their roles in mutating and restricting the infection of human immunodeficiency virus type 1 (HIV-1). However, this virus has evolved effective strategies to dodge the effects of these host intrinsic proteins; one of them is through the expression of the viral infectivity factor (Vif) (Desimmie et al, 2014). The main role of Vif is to protect HIV-1 from the deleterious actions of A3G and A3F (and some other members of the A3 family) by linking these proteins to the E3 ubiquitin ligase complex, which then targets them for degradation in the proteasome (Kobayashi et al, 2005;Liu et al, 2004;Mehle et al, 2004;Yu et al, 2003).…”
Section: Introductionmentioning
confidence: 99%