Multiple anthelmintic resistance of nematodes in imported goats

Várady, Marián; Praslička, J.; Corba, J; Veselý, Lukáš

doi:10.1136/vr.132.15.387

Cited by 43 publications

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“…In Spain, the first anthelmintic resistance recorded occurred after Cashmere goats were imported from the United Kingdom [78], where a high prevalence of anthelmintic resistance in fibre producing goats had been recorded [56]. The same situation was observed in Angora goats imported to Slovakia from New Zealand [96] and sheep imported to Greece from Great Britain [51]. In French dairy goat farms, no infected animals are introduced after the flock has been set up.…”

Section: Introduction Of Animals Harbouring Anthelmintic Resistant Nementioning

confidence: 86%

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

et al. 2002

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-Although the molecular bases of resistance to anthelmintic families have been intensively studied, the contributing factors for the development of anthelmintic resistance are less well known. Clear recommendations must be given to farmers in order to delay the onset of anthelmintic resistance. Until now, the main advice has concerned the reduction of treatment frequency in order to slow down the spread of resistance. Anthelmintic resistance development depends mostly on an efficient selection pressure. This means that a high treatment frequency is neither necessary nor sufficient to select for resistance. The contribution of resistant worms, which have survived an anthelmintic treatment, to the subsequent generation is the key factor that controls resistance spread. This point is illustrated by five surveys conducted on sheep and goat farms from France and Morocco. In the 52 farms studied, less than three anthelmintic treatments were given each year. Three characteristics of breeding management can be identified in the build up of anthelmintic resistance: (1) the introduction of resistant worms through the purchase of sheep/goats or the use of common pastures, grazed by several herds/flocks, (2) under-dosing of hosts and the repeated use of one class of drugs, (3) the size of the population in refugia (infective larvae on pastures) at the time of the treatment. The role played by these breeding management factors in selecting for resistance is discussed. The most efficient way to limit the increase of anthelmintic resistance remains the reduction of the selection pressure by drugs, and optimal timing to maximise their efficacy. Bien que les bases moléculaires de la résistance aux différentes familles d'anthelminthiques aient été très étudiées, les facteurs permettant le développement de la résistance anthelminthique sont moins bien connus. Des recommandations claires sont nécessaires aux éleveurs si l'on souhaite retarder l'apparition de la résistance aux anthelminthiques. La principale recommandation a consisté à réduire la fréquence des traitements de façon à ralentir le développement de la résis-tance. Le développement de la résistance anthelminthique dépend essentiellement d'une pression de sélection efficace. Cela signifie qu'une forte fréquence de traitements n'est ni nécessaire ni suffisante pour sélectionner la résistance. La contribution des vers résistants, qui ont survécu au traitement anthelminthique, à la génération suivante est le facteur clé qui contrôle le développement de la résis-tance. Ce point est illustré par cinq enquêtes réalisées dans des élevages ovins et caprins de France et du Maroc. Dans les 52 élevages étudiés, moins de trois traitements anthelminthiques par an étaient réalisés. Trois conditions d'élevage ont pu être mises en évidence comme étant impliquées dans le dé-veloppement de la résistance anthelminthique :

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Section: Introduction Of Animals Harbouring Anthelmintic Resistant Nementioning

confidence: 86%

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

et al. 2002

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“…Anthelmintic resistance is not yet common amongst GI nematodes of humans, but already there are some indications that previously effective anthelmintics are losing efficacy (De Clercq et al 1997 ;Reynoldson et al 1997 ;Albonico et al 2003). Resistance is now a major threat to sheep and goat farming in the Southern hemisphere, with multiple drug-resistant parasites present (Varady et al 1993 ;Mwamachi et al 1995 ;van Wyk, Malan and Randles, 1997 ;Waruiru, Ngotho and Mukiri, 1998). New synthetic anthelmintic drugs or vaccines are unlikely to be available in the near future, so alternative strategies for the control of these parasite infections are urgently required.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris

et al. 2006

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“…Em 1981, surgiram as avermectinas, entretanto a resistência ao ivermectin, importante droga deste grupo, tem sido registrada em caprinos parasitados, principalmente por Ostertagia circumcincta e Haemonchus contortus em vários países (Varady et al 1993, Terril et al 2001, Gatongi et al 2003 inclusive no Brasil (Mattos et al 1997). No Nordeste brasileiro, desde a década de 80 a resistência anti-helmíntica em nematóides de caprinos vem sendo estudada, principalmente no Ceará (Vieira et al 1989), em Pernambuco e Bahia (Barreto & Silva 1999).…”

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Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

Rodrigues

Athayde²,

Rodrigues³

et al. 2007

Pesq. Vet. Bras.

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Evalu-Evalu-EvaluEvalu-Evaluation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats ation of the efficacy of antihelmintics to control gastrointestinal nematodes in goats raised in the state of P raised in the state of P raised in the state of P raised in the state of P raised in the state of Paraíba araíba araíba araíba araíba.] Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do sertão paraibano. Pesquisa Veterinária Brasileira 27 (4) The objective was to evaluate conventional and alternative anthelminthic action on the sensibility of gastrointestinal nematodes in goats. Hundred and twenty goats of both sexes were distributed into 10 groups of 24 animals each (12 males and 12 females) and submitted to treatments of specific anthelminthic composition. The commercial drugs used were moxidectin 0.2%, albendazole, levamisol chlorhydrate, ivermectin and an aqueous extract of the purgative potato (Operculina hamiltonii). The reduction test was applied through egg counts per gram of feces and larval culture to evaluate resistance. The fecal samples were collected in the day when medication was accomplished (day base), at 7, 14 and 21 days after treatment. The following results for the reduction of Trichostrongyloidea eggs were obtained: Treatment of the females with Moxidectina reduced the egg counts to 92.8, 88.7 and 89.8%, of the males to 92.6, 96.2 and 98.1%; with Levamisol of the females to 96, 97.1 and 91%, of the males to 85.7, 94,2 and 100%; with Albendazol of the females 65, 60.3 and 75.4%, of the males 88.8, 88.8 and 55.5%; with Ivermectin of the females to 92.2, 68.6 and 70.6%, of the males to 41.7, 73.6 and 59.7%; and with the purgative potato of the females to 31.8, 34.1 and 49.4%, of the males to 61.5, 80.7 and 50%. In larval culture Haemonchus, followed by Bunostomum, Trichostrongylus, and Oesophagostomum, were identified even after treatments.

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Multiple anthelmintic resistance of nematodes in imported goats

Cited by 43 publications

References 0 publications

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

Sheep and goat nematode resistance to anthelmintics: pro and cons among breeding management factors

In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris

Sensibilidade dos nematóides gastrintestinais de caprinos a anti-helmínticos na mesorregião do Sertão Paraibano

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