Multiple anthelmintic resistance in gastrointestinal nematodes of small ruminants in Bangladesh

Dey, Anita Rani; Begum, Nurjahan; Anisuzzaman, Anisuzzaman; Alim, Md. Abdul; Alam, Mohammad Zahangir

doi:10.1016/j.parint.2020.102105

Cited by 25 publications

(24 citation statements)

References 36 publications

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“…However, the Hangjin Banner and Ejin Horo Banner lack relevant professional training, and herders have little awareness of parasite control. However, the infection rate of GINs in sheep in Ordos is lower than that in Ethiopia (83%) [ 22 ], Bangladesh (77.1%) [ 23 ], South Africa (81%) [ 24 ] and Algeria (96%) [ 25 ]. Although the different breeds, detection methods, geographical differences and sample sizes are factors that may contribute to varying infection [ 26 ], the infection rate of GINs in Ordos is still low.…”

Section: Discussionmentioning

confidence: 99%

Positivity Rate Investigation and Anthelmintic Resistance Analysis of Gastrointestinal Nematodes in Sheep and Cattle in Ordos, China

Hou

Yong

Wuen

et al. 2022

Animals

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Gastrointestinal nematodes (GINs), such as Trichostrongylidae, are important pathogens in small ruminants, causing significant losses in these livestock species. Despite their veterinary importance, GINs have not been studied in certain regions of the world. Therefore, much of their epidemiology and economic impact on production remain unknown. In the present study, a systematic epidemiological survey based on the modified McMaster technique was conducted to investigate the type and infection of GINs in sheep and cattle. In 9622 fecal samples from 491 sampling sites in the four main banner districts of Ordos, the prevalence of GIN infection was found to be 38.84% and 4.48% in sheep and cattle, respectively. At the same time, the effects of four pasture types on the distribution of GINs were analyzed. This study also found severe resistance to ivermectin and albendazole in GINs and suspected anthelmintic resistance in nitroxynil, levamisole and closantel. We report the type and infection of GINs in Ordos, with the aim to help the prevention and control of GINs. Based on the results of the questionnaire survey and GIN resistance test, we found several reasons for the anthelmintic resistance of GINs, consequently providing new ideas for controlling the occurrence of anthelmintic resistance.

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Section: Discussionmentioning

confidence: 99%

Positivity Rate Investigation and Anthelmintic Resistance Analysis of Gastrointestinal Nematodes in Sheep and Cattle in Ordos, China

Hou

Yong

Wuen

et al. 2022

Animals

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“…Santos et al (2019) detected 76.7% of the resistance allele frequencies after continuous use of the drug, which was similar to the values presented in the rainy season for the ST group. The allele for resistance was identi ed in properties in Bangladesh with a percentage ranging from 25% to 47% (Dey et al 2020). However, as the characterization of levamisole resistance was not possible in some H. contortus parasitic populations studies suggest that the role of this polymorphism should be better investigated (Santos et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Benefits of Target Selective Treatment by Average Daily Weight Gain Against Gastrointestinal Nematodes in Morada Nova Lambs

Santos

Anholeto

Sousa

et al. 2022

Preprint

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Gastrointestinal nematodes are the major obstacle to sheep farming, and their rational control depends on reliable parameters that guarantee both productivity and animal health. Thus, the objective of this study was to evaluate a method of targeted selective treatment (TST) of Morada Nova lambs, using the average daily weight gain (DWG). For this, 114 lambs in the rainy and 102 in the dry season were randomized into three treatments: Control (CT), Routine (RT - treated every 42 days), and Targeted Selective (TST - treated according to DWG). Packed cell volume (PCV) and eggs per gram of feces (EPG) tests were performed. Intending to investigate the resistance of parasites to anthelmintic, the EPG count reduction test (FECRT), RESISTA-Test© and molecular test (detection of a 63 bp indel in the acr-8 gene in Haemonchus contortus) were performed. For CT, RT and TST groups, the following results were obtained: mean EPG were 4665.1, 3063.5 and 3462.1 in the rainy season and 4475.1, 1341.7 and 2863.4 in the dry season, respectively; mean PCV were 32.1, 33.4 and 32.3% in the rainy season and 33.9, 36.0 and 35.1% in the dry season; mean DWG were 0.087, 0.101 and 0.094 kg in the rainy season and 0.102, 0.113 and 0.112 kg in the dry season; efficacies of levamisole in FECRT were 66.4, 24.1 and 76.4% in the rainy and 90.7, 12.4 and 64.8% in the dry season, respectively; in the RESISTA-Test© LC50 were 0.482, 1.926 and 0.117 µg.mL-1 in the rainy and 0.437, 0.851 and 0.045 µg.mL-1 in the dry season, respectively; in the molecular test, the frequencies of the homozygous resistant genotype were 57.1, 71.4 and 40.0% in the rainy season and 47.8, 55.9 and 41.9% in the dry season. In conclusion, TST allowed less resistance development through refugia maintenance, without productive losses, contributing to the sustainability of the sheep chain.

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“…was together with H. contortus and Trichostrongylus spp. resistant to BZ and ML [ 63 , 64 ]. Moreover, our observation has to be treated with caution as the only DC which has been scientifically proven to indicate AR is the DC of IVM-AG for H. contortus .…”

Section: Discussionmentioning

confidence: 99%

“…Studies so far conducted in sheep and goats have indicated that both Trichostrongylus spp. and H. contortus are responsible for AR to LEV [11,13,14,16,25,37,38,54,57,[63][64][65][66][67][68][69].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

et al. 2021

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Background Helminthic infections, in particular those caused by gastrointestinal nematodes (GIN), are found worldwide and are among the most economically important diseases of goats. Anthelmintic resistance (AR) in GIN of goats is currently present worldwide, and single- or multidrug resistant species are widespread. The aim of this study was to determine the prevalence of AR to benzimidazoles (BZ), macrocyclic lactones (ML) and imidazothiazoles represented by levamisole (LEV) in the Polish goat herds by using an in vitro larval development test, which is useful especially in large-scale epidemiological surveys. Results This cross-sectional study was conducted from September 2018 to June 2019 and enrolled 42 dairy goat herds scattered over the entire country. The most commonly used anthelmintic class in goat herds in Poland were BZ (92%), followed by ML (85%) and LEV (13%). BZ-resistant GIN populations were found in 37 herds (88%, CI 95%: 75 to 95%), ML-resistant GIN populations in 40 herds (95%, CI 95, 84 to 99%), and LEV-resistant GIN populations in 5 herds (12%, CI 95%: 5 to 25%). Multidrug resistance involving all three anthelmintic classes was found in 5 herds (12%, CI 95, 5 to 25%). Based on the morphological features of stage 3 larvae the main resistant GIN turned out to be Haemonchus contortus and Trichostrongylus spp. The use of BZ and frequency of anthelmintic treatments were significantly related to the presence of AR to BZ in Polish goat herds. Conclusions This cross-sectional study demonstrates the existence of AR to BZ, ML and LEV on Polish goat farms. Resistance to BZ and ML is widespread, while AR to LEV is currently at a low level. A considerable proportion of herds harbours multidrug resistant GIN, which requires further consideration. An effective anthelmintic treatment strategy, reasonable preventive measures and better understanding of the resistance-related management practices by farmers and veterinarians may delay further development of AR.

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Multiple anthelmintic resistance in gastrointestinal nematodes of small ruminants in Bangladesh

Cited by 25 publications

References 36 publications

Positivity Rate Investigation and Anthelmintic Resistance Analysis of Gastrointestinal Nematodes in Sheep and Cattle in Ordos, China

Positivity Rate Investigation and Anthelmintic Resistance Analysis of Gastrointestinal Nematodes in Sheep and Cattle in Ordos, China

Investigating the Benefits of Target Selective Treatment by Average Daily Weight Gain Against Gastrointestinal Nematodes in Morada Nova Lambs

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

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