Multiple and terminal grafting of linear polyglycidol for surfaces of reduced protein adsorption

Utrata-Wesołek, Alicja; Wałach, Wojciech; Anioł, Jacek; Sieroń, Aleksander; Dworak, Andrzej

doi:10.1016/j.polymer.2016.05.016

Cited by 21 publications

(14 citation statements)

References 53 publications

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“…This value appeared a reasonable choice, as very thin hydrogel coatings (<30 nm) seem prone to enhanced fouling [74,75]. Still, reports are somewhat conflicting with respect to the existence and range of an optimal thickness of thin hydrogel films for reducing protein fouling [76,77,78,79,80,81]. Hence in prior exploratory experiments with reference copolymer P−x3a (P−xSPE), we clarified that protein adsorption increased notably when the thickness of hydrogel films dropped below 80 nm, whereas the adsorbed amounts were about the same for thicknesses up to 120 nm at least (vide infra, see also Figure 7a below).…”

Section: Resultsmentioning

confidence: 99%

Surface Modification by Polyzwitterions of the Sulfabetaine-Type, and Their Resistance to Biofouling

et al. 2019

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Films of zwitterionic polymers are increasingly explored for conferring fouling resistance to materials. Yet, the structural diversity of polyzwitterions is rather limited so far, and clear structure-property relationships are missing. Therefore, we synthesized a series of new polyzwitterions combining ammonium and sulfate groups in their betaine moieties, so-called poly(sulfabetaine)s. Their chemical structures were varied systematically, the monomers carrying methacrylate, methacrylamide, or styrene moieties as polymerizable groups. High molar mass homopolymers were obtained by free radical polymerization. Although their solubilities in most solvents were very low, brine and lower fluorinated alcohols were effective solvents in most cases. A set of sulfabetaine copolymers containing about 1 mol % (based on the repeat units) of reactive benzophenone methacrylate was prepared, spin-coated onto solid substrates, and photo-cured. The resistance of these films against the nonspecific adsorption by two model proteins (bovine serum albumin—BSA, fibrinogen) was explored, and directly compared with a set of references. The various polyzwitterions reduced protein adsorption strongly compared to films of poly(n‑butyl methacrylate) that were used as a negative control. The poly(sulfabetaine)s showed generally even somewhat higher anti-fouling activity than their poly(sulfobetaine) analogues, though detailed efficacies depended on the individual polymer–protein pairs. Best samples approach the excellent performance of a poly(oligo(ethylene oxide) methacrylate) reference.

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Section: Resultsmentioning

confidence: 99%

Surface Modification by Polyzwitterions of the Sulfabetaine-Type, and Their Resistance to Biofouling

et al. 2019

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“…For this reason, thermoresponsive derivatives of polyglycidol mPGL were obtained [ 92 , 93 , 94 , 95 ] and then immobilized on a support [ 91 ]. Similar to the case of nonmodified PGL [ 90 ], tethering of the copolymer led to layers of interpenetrating polymer chains multiply attached to the support. The layer thickness and morphology could be easily controlled by the conditions applied during the preparation of layers.…”

Section: Polymer Nano- and Microstructurementioning

confidence: 89%

“…The first type concerns interpenetrating polymer chains multiply attached to the support ( Figure 8 f). This type of layer was obtained from the linear homo- and copolymer of glycidol and its thermoresponsive derivative mPGL [ 90 , 91 ]. (Co)polymers were covalently attached by the esterification reaction between hydroxyl groups of (co)polyglycidols and anhydride groups introduced onto the surface.…”

Section: Polymer Nano- and Microstructurementioning

confidence: 99%

“…As -OH groups are distributed along the linear (co)polyglycidol chain, thus tethering to the support occurs at many points on the polymer chain. Layers of thickness in the range of 7–140 nm (dependent on polymer molar mass, concentration) were created [ 90 ]. Hydrophilic PGL layers were applied as antifouling materials against fibrinogen.…”

Section: Polymer Nano- and Microstructurementioning

confidence: 99%

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The Role of Polymer Structure in Formation of Various Nano- and Microstructural Materials: 30 Years of Research in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials PAS

et al. 2021

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The review summarizes the research carried out in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials, Polish Academy of Sciences (CMPW PAS). Studies carried out for many years under the guidance of Professor Andrzej Dworak led to the development and exploration of the mechanisms of oxirane and cyclic imine polymerization and controlled radical polymerization of methacrylate monomers. Based on that knowledge, within the last three decades, macromolecules with the desired composition, molar mass and topology were obtained and investigated. The ability to control the structure of the synthesized polymers turned out to be important, as it provided a way to tailor the physiochemical properties of the materials to their specific uses. Many linear polymers and copolymers as well as macromolecules with branched, star, dendritic and hyperbranched architectures were synthesized. Thanks to the applied controlled polymerization techniques, it was possible to obtain hydrophilic, hydrophobic, amphiphilic and stimulus-sensitive polymers. These tailor-made polymers with controlled properties were used for the construction of various types of materials, primarily on the micro- and nanoscales, with a wide range of possible applications, mainly in biomedicine. The diverse topology of polymers, and thus their properties, made it possible to obtain various types of polymeric nanostructures and use them as nanocarriers by encapsulation of biologically active substances. Additionally, polymer layers were obtained with features useful in medicine, particularly regenerative medicine and tissue engineering.

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“…The most frequently studied polymers containing zwitterions are poly(sulfobetaine), poly(carboxybetaine), and poly(phosphorylcholine) [131,132]. Hydrophilic materials that prevent surface biofouling include PEG, oligo(ethylene glycol)s, poly(methacrylates of ethylene glycol), polyacrylamides, polysaccharides, and polyglycidol [132][133][134][135][136][137].…”

Section: Antifouling Surfacesmentioning

confidence: 99%

Polymers in medicine direction of development

et al. 2019

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The paper constitutes a brief and subjective review of polymeric materials in the contemporary health service. The range of applications of polymeric materials is discussed, special att ention being paid to such materials for the development of carriers of pharmaceutically active species, stents and vascular prostheses, amongst them to the application of "smart" materials for these purposes, layers and scaff olds for the growth of organs and tissues, antifouling layers. The authors try to turn the att ention of the reader to the research and intellectual eff orts necessary for the development of polymeric materials for the medicine, and conclude about the growing importance of such studies.

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Multiple and terminal grafting of linear polyglycidol for surfaces of reduced protein adsorption

Cited by 21 publications

References 53 publications

Surface Modification by Polyzwitterions of the Sulfabetaine-Type, and Their Resistance to Biofouling

Surface Modification by Polyzwitterions of the Sulfabetaine-Type, and Their Resistance to Biofouling

The Role of Polymer Structure in Formation of Various Nano- and Microstructural Materials: 30 Years of Research in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials PAS

Polymers in medicine direction of development

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